A risk model developed based on tumor microenvironment predicts overall survival and associates with tumor immunity of patients with lung adenocarcinoma

Tumor microenvironment (TME) has been reported to exhibit a crucial effect in lung cancer. Therefore, this study was aimed to investigate the genes associated with TME and develop a risk score to predict the overall survival (OS) of patients with lung adenocarcinoma (LUAD) based on these genes. The...

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Bibliographic Details
Published in:	Oncogene Vol. 40; no. 26; pp. 4413 - 4424
Main Authors:	Wu, Jie, Li, Lan, Zhang, Huibo, Zhao, Yaqi, Zhang, Haohan, Wu, Siyi, Xu, Bin
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.07.2021 Nature Publishing Group
Subjects:	38/39 38/43 45/61 631/67/1612/1350 692/53/2422 Adenocarcinoma Adenocarcinoma of Lung - genetics Adenocarcinoma of Lung - immunology Adenocarcinoma of Lung - mortality Adenocarcinoma of Lung - pathology Apoptosis Biomarkers, Tumor - genetics Cancer Care and treatment CD4 antigen CD8 antigen Cell Biology CX3CR1 protein Gene expression Gene Expression Regulation, Neoplastic - genetics Gene Expression Regulation, Neoplastic - immunology Genetic aspects Genomes Histocompatibility antigen HLA Human Genetics Humans Immune checkpoint Immunity - genetics Immunity - immunology Immunotherapy Immunotherapy - methods Interferon regulatory factor 1 Internal Medicine Leukocytes (neutrophilic) Lung cancer Lung Neoplasms - genetics Lung Neoplasms - immunology Lung Neoplasms - mortality Lung Neoplasms - pathology Lymphocytes B Lymphocytes T Macrophages Medicine Medicine & Public Health Metastases Mutation Mutation - genetics Oncology Oncology, Experimental Patient outcomes Phenotypes Prognosis Tumor microenvironment Tumor Microenvironment - genetics Tumor Microenvironment - immunology China
ISSN:	0950-9232, 1476-5594, 1476-5594
Online Access:	Get full text
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