Aggressive familial ALS with unusual brain MRI and a SOD1 gene mutation

We studied two sisters with rapidly progressing ALS starting at the ages of 46 and 48 years and leading to death after 14 months. Both fulfilled the El Escorial criteria for definite ALS and had marked upper motor neuron (UMN) predominance. Brain MRI, on fluid attenuation recovery (FLAIR) mode, show...

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Vydáno v:Amyotrophic lateral sclerosis Ročník 11; číslo 1-2; s. 228 - 231
Hlavní autoři: Blumen, Sergiu C., Inzelberg, Rivka, Nisipeanu, Puiu, Carasso, Ralph L., Oved, Daniel, Aizenstein, Orna, Drory, Vivian E., Bergstrom, Christina, Andersen, Peter M.
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Informa UK Ltd 2010
Taylor & Francis
Témata:
'Silent' A140A SOD1 mutation
Amino Acid Substitution - genetics
Amyotrophic Lateral Sclerosis - genetics
Amyotrophic Lateral Sclerosis - pathology
Brain - pathology
Familial ALS
Family Health
Fatal Outcome
Female
Humans
Magnetic Resonance Imaging
Middle Aged
MRI in ALS
Pedigree
Severity of Illness Index
Siblings
SOD1 mutation
Superoxide Dismutase - genetics
Superoxide Dismutase-1
ISSN:1748-2968, 1471-180X, 1471-180X
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Abstract We studied two sisters with rapidly progressing ALS starting at the ages of 46 and 48 years and leading to death after 14 months. Both fulfilled the El Escorial criteria for definite ALS and had marked upper motor neuron (UMN) predominance. Brain MRI, on fluid attenuation recovery (FLAIR) mode, showed outstanding hyperintensities of the precentral gyrus, centrum semiovale, corona radiata and along the corticospinal pathways in the brainstem. Screening for the SOD1 gene disclosed, at codon 140, a base substitution of adenine for thymine (GGT>CCA) known as the A140A 'silent' mutation since it does not change the amino acid (alanine) encoded for at that position. The severe UMN involvement and the fast progression of the disease may correlate with the MRI findings. It is also possible that the A140A mutation is not incidental; the mutated mRNA might be cytotoxic.
AbstractList We studied two sisters with rapidly progressing ALS starting at the ages of 46 and 48 years and leading to death after 14 months. Both fulfilled the El Escorial criteria for definite ALS and had marked upper motor neuron (UMN) predominance. Brain MRI, on fluid attenuation recovery (FLAIR) mode, showed outstanding hyperintensities of the precentral gyrus, centrum semiovale, corona radiata and along the corticospinal pathways in the brainstem. Screening for the SOD1 gene disclosed, at codon 140, a base substitution of adenine for thymine (GGT>CCA) known as the A140A 'silent' mutation since it does not change the amino acid (alanine) encoded for at that position. The severe UMN involvement and the fast progression of the disease may correlate with the MRI findings. It is also possible that the A140A mutation is not incidental; the mutated mRNA might be cytotoxic.We studied two sisters with rapidly progressing ALS starting at the ages of 46 and 48 years and leading to death after 14 months. Both fulfilled the El Escorial criteria for definite ALS and had marked upper motor neuron (UMN) predominance. Brain MRI, on fluid attenuation recovery (FLAIR) mode, showed outstanding hyperintensities of the precentral gyrus, centrum semiovale, corona radiata and along the corticospinal pathways in the brainstem. Screening for the SOD1 gene disclosed, at codon 140, a base substitution of adenine for thymine (GGT>CCA) known as the A140A 'silent' mutation since it does not change the amino acid (alanine) encoded for at that position. The severe UMN involvement and the fast progression of the disease may correlate with the MRI findings. It is also possible that the A140A mutation is not incidental; the mutated mRNA might be cytotoxic.
We studied two sisters with rapidly progressing ALS starting at the ages of 46 and 48 years and leading to death after 14 months. Both fulfilled the El Escorial criteria for definite ALS and had marked upper motor neuron (UMN) predominance. Brain MRI, on fluid attenuation recovery (FLAIR) mode, showed outstanding hyperintensities of the precentral gyrus, centrum semiovale, corona radiata and along the corticospinal pathways in the brainstem. Screening for the SOD1 gene disclosed, at codon 140, a base substitution of adenine for thymine (GGT>CCA) known as the A140A 'silent' mutation since it does not change the amino acid (alanine) encoded for at that position. The severe UMN involvement and the fast progression of the disease may correlate with the MRI findings. It is also possible that the A140A mutation is not incidental; the mutated mRNA might be cytotoxic.
Author Aizenstein, Orna
Drory, Vivian E.
Blumen, Sergiu C.
Andersen, Peter M.
Carasso, Ralph L.
Oved, Daniel
Bergstrom, Christina
Inzelberg, Rivka
Nisipeanu, Puiu
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SubjectTerms 'Silent' A140A SOD1 mutation
Amino Acid Substitution - genetics
Amyotrophic Lateral Sclerosis - genetics
Amyotrophic Lateral Sclerosis - pathology
Brain - pathology
Familial ALS
Family Health
Fatal Outcome
Female
Humans
Magnetic Resonance Imaging
Middle Aged
MRI in ALS
Pedigree
Severity of Illness Index
Siblings
SOD1 mutation
Superoxide Dismutase - genetics
Superoxide Dismutase-1
Title Aggressive familial ALS with unusual brain MRI and a SOD1 gene mutation
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