Inside-Out of Complement in Cancer

The role of complement in cancer has received increasing attention over the last decade. Recent studies provide compelling evidence that complement accelerates cancer progression. Despite the pivotal role of complement in fighting microbes, complement seems to suppress antitumor immunity via regulat...

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Published in:Frontiers in immunology Vol. 13; p. 931273
Main Authors: Kolev, Martin, Das, Madhumita, Gerber, Monica, Baver, Scott, Deschatelets, Pascal, Markiewski, Maciej M.
Format: Journal Article
Language:English
Published: Frontiers Media S.A 01.07.2022
Subjects:
biomarkers
cancer
extracellular complement
Immunology
intracellular complement
therapy
tumor microenvironment
ISSN:1664-3224, 1664-3224
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Abstract The role of complement in cancer has received increasing attention over the last decade. Recent studies provide compelling evidence that complement accelerates cancer progression. Despite the pivotal role of complement in fighting microbes, complement seems to suppress antitumor immunity via regulation of host cell in the tumor microenvironment. Although most studies link complement in cancer to complement activation in the extracellular space, the discovery of intracellular activation of complement, raises the question: what is the relevance of this process for malignancy? Intracellular activation is pivotal for the survival of immune cells. Therefore, complement can be important for tumor cell survival and growth regardless of the role in immunosuppression. On the other hand, because intracellular complement (the complosome) is indispensable for activation of T cells, these functions will be essential for priming antitumor T cell responses. Here, we review functions of complement in cancer with the consideration of extra and intracellular pathways of complement activation and spatial distribution of complement proteins in tumors and periphery and provide our take on potential significance of complement as biomarker and target for cancer therapy.
AbstractList The role of complement in cancer has received increasing attention over the last decade. Recent studies provide compelling evidence that complement accelerates cancer progression. Despite the pivotal role of complement in fighting microbes, complement seems to suppress antitumor immunity via regulation of host cell in the tumor microenvironment. Although most studies link complement in cancer to complement activation in the extracellular space, the discovery of intracellular activation of complement, raises the question: what is the relevance of this process for malignancy? Intracellular activation is pivotal for the survival of immune cells. Therefore, complement can be important for tumor cell survival and growth regardless of the role in immunosuppression. On the other hand, because intracellular complement (the complosome) is indispensable for activation of T cells, these functions will be essential for priming antitumor T cell responses. Here, we review functions of complement in cancer with the consideration of extra and intracellular pathways of complement activation and spatial distribution of complement proteins in tumors and periphery and provide our take on potential significance of complement as biomarker and target for cancer therapy.
The role of complement in cancer has received increasing attention over the last decade. Recent studies provide compelling evidence that complement accelerates cancer progression. Despite the pivotal role of complement in fighting microbes, complement seems to suppress antitumor immunity via regulation of host cell in the tumor microenvironment. Although most studies link complement in cancer to complement activation in the extracellular space, the discovery of intracellular activation of complement, raises the question: what is the relevance of this process for malignancy? Intracellular activation is pivotal for the survival of immune cells. Therefore, complement can be important for tumor cell survival and growth regardless of the role in immunosuppression. On the other hand, because intracellular complement (the complosome) is indispensable for activation of T cells, these functions will be essential for priming antitumor T cell responses. Here, we review functions of complement in cancer with the consideration of extra and intracellular pathways of complement activation and spatial distribution of complement proteins in tumors and periphery and provide our take on potential significance of complement as biomarker and target for cancer therapy.The role of complement in cancer has received increasing attention over the last decade. Recent studies provide compelling evidence that complement accelerates cancer progression. Despite the pivotal role of complement in fighting microbes, complement seems to suppress antitumor immunity via regulation of host cell in the tumor microenvironment. Although most studies link complement in cancer to complement activation in the extracellular space, the discovery of intracellular activation of complement, raises the question: what is the relevance of this process for malignancy? Intracellular activation is pivotal for the survival of immune cells. Therefore, complement can be important for tumor cell survival and growth regardless of the role in immunosuppression. On the other hand, because intracellular complement (the complosome) is indispensable for activation of T cells, these functions will be essential for priming antitumor T cell responses. Here, we review functions of complement in cancer with the consideration of extra and intracellular pathways of complement activation and spatial distribution of complement proteins in tumors and periphery and provide our take on potential significance of complement as biomarker and target for cancer therapy.
The role of complement in cancer has received increasing attention over the last decade. Recent studies provide compelling evidence that complement accelerates cancer progression. Despite the pivotal role of complement in fighting microbes, complement seems to suppress antitumor immunity via regulation of host cell in the tumor microenvironment. Although most studies link complement in cancer to complement activation in the extracellular space, the discovery of intracellular activation of complement, raises the question: what is the relevance of this process for malignancy? Intracellular activation is pivotal for the survival of immune cells. Therefore, complement can be important for tumor cell survival and growth regardless of the role in immunosuppression. On the other hand, because intracellular complement (the complosome) is indispensable for activation of T cells, these functions will be essential for priming antitumor T cell responses. Here, we review functions of complement in cancer with the consideration of extra and intracellular pathways of complement activation and spatial distribution of complement proteins in tumors and periphery and provide our take on potential significance of complement as biomarker and target for cancer therapy.
Author Deschatelets, Pascal
Markiewski, Maciej M.
Gerber, Monica
Baver, Scott
Kolev, Martin
Das, Madhumita
AuthorAffiliation 1 Discovery, Apellis Pharmaceuticals, Waltham , MA , United States
4 Department of Immunotherapeutics and Biotechnology, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center , Abilene, TX , United States
3 Medical Affairs, Apellis Pharmaceuticals, Waltham , MA , United States
2 Legal Department, Apellis Pharmaceuticals, Waltham , MA , United States
AuthorAffiliation_xml – name: 3 Medical Affairs, Apellis Pharmaceuticals, Waltham , MA , United States
– name: 2 Legal Department, Apellis Pharmaceuticals, Waltham , MA , United States
– name: 1 Discovery, Apellis Pharmaceuticals, Waltham , MA , United States
– name: 4 Department of Immunotherapeutics and Biotechnology, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center , Abilene, TX , United States
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Cites_doi 10.1016/J.IMMUNI.2020.02.006
10.1016/J.IMMUNI.2021.03.003
10.1038/leu.2014.185
10.1136/JITC-2021-002585
10.3389/FIMMU.2017.01245
10.1038/nrneph.2016.70
10.3389/FIMMU.2014.00520
10.1016/J.CELREP.2014.02.014
10.1158/1078-0432.CCR-10-0321
10.3389/FIMMU.2021.629986
10.3389/FIMMU.2018.02203/BIBTEX
10.1021/ACS.ANALCHEM.9B03074
10.1073/PNAS.1910952117/-/DCSUPPLEMENTAL
10.3389/FIMMU.2015.00262
10.1038/S41598-020-75376-Z
10.3390/DIAGNOSTICS10121077
10.1158/2326-6066.CIR-20-0532
10.1158/2326-6066.CIR-20-0203
10.1038/s41568-019-0210-0
10.1007/978-1-4614-5915-6_11
10.1016/J.IMBIO.2019.07.006
10.1038/ni.1655
10.1016/J.EJCA.2018.05.007
10.1093/jnci/djt205
10.1158/2326-6066.CIR-15-0122
10.1016/J.MOLIMM.2017.05.012
10.1016/J.PAN.2013.03.010
10.1007/S40265-015-0399-5
10.1126/SCIENCE.1248943
10.1186/2049-3002-1-5
10.1038/S41598-021-84568-0
10.1097/PAI.0B013E31821A0BE9
10.1016/J.CCELL.2018.09.003
10.1158/2326-6066.CIR-18-0891
10.1158/2159-8290.CD-17-1246
10.1038/s41392-021-00485-8
10.1016/J.YEXCR.2018.03.009
10.1016/J.CELREP.2020.107628
10.1016/J.SEMNEPHROL.2013.08.001
10.1016/J.MOLIMM.2019.07.030
10.1186/S13046-019-1515-2/FIGURES/6
10.1007/S13402-021-00614-Z/FIGURES/6
10.1007/S12033-012-9547-2
10.1172/JCI89412
10.1016/S0161-5890(03)00112-3
10.1038/NRI3761
10.1038/s41467-018-06706-z
10.2217/FON-2017-0498
10.3389/FIMMU.2017.00001
10.1038/S43018-021-00173-0
10.4049/JIMMUNOL.1600210
10.1016/J.SMIM.2018.02.003
10.3390/IJMS21082824
10.1038/NRNEPH.2017.156
10.1126/SCIENCE.AAO4555
10.3390/MEDICINA57020085
10.4049/JIMMUNOL.173.4.2524
10.3389/FONC.2020.617890
10.3390/ANTIB9040057
10.1182/BLOOD.V124.21.1421.1421
10.4049/JIMMUNOL.1003032
10.4049/jimmunol.134.3.1804
10.3390/IJMS22168572
10.3389/FIMMU.2018.01629/BIBTEX
10.1158/2326-6066.CIR-21-0258
10.4049/JIMMUNOL.1300847
10.1016/J.SEMCDB.2017.11.023
10.1038/s41586-019-1608-2
10.1158/2326-6066.CIR-20-0787
10.1016/J.CMET.2017.06.004
10.1172/JCI135105
10.1016/J.MOLIMM.2014.07.004
10.1038/NRI.2017.97
10.1038/nri.2017.97
10.1186/1476-4598-9-139
10.1158/2326-6066.CIR-18-0272
10.1158/2159-8290.CD-16-1184
10.1007/S12026-014-8542-Z
10.1016/J.IMMUNI.2015.05.024
10.1038/bjc.2016.295
10.1080/15548627.2019.1580515
10.2147/JIR.S121233
10.3892/OR_00000368
10.3892/MCO.2017.1524
10.1158/0008-5472.CAN-18-3962
10.4049/JIMMUNOL.1502287
10.1186/S12885-021-08818-0
10.3389/FIMMU.2019.00672
10.1038/s41388-020-1169-8
10.1126/SCIIMMUNOL.ABF2489
10.1126/SCIENCE.AAD0501
10.1038/ni.1917
10.1146/ANNUREV-IMMUNOL-042617-053245
10.1056/NEJMOA2029073/SUPPL_FILE/NEJMOA2029073_DATA-SHARING.PDF
10.20892/J.ISSN.2095-3941.2020.0430
10.1042/BJ3300163
10.1038/339620a0
10.3390/IJMS21020602
10.1016/J.CELL.2015.01.004
10.1038/sj.bjc.6605448
10.1021/PR5002719/SUPPL_FILE/PR5002719_SI_001.PDF
10.1111/IMR.12852
10.1126/SCIENCE.AAD1210
10.7754/CLIN.LAB.2020.200249
10.1016/J.CELREP.2016.04.038
10.4049/jimmunol.159.3.1429
10.1016/J.IMMUNI.2013.10.018
10.4049/JIMMUNOL.2000511
10.2147/OTT.S234920
10.1002/JEV2.12031
10.3389/FIMMU.2015.00257
10.1016/J.LEUKRES.2008.05.014
10.1038/S41573-019-0031-6
10.3389/FIMMU.2019.00752/BIBTEX
10.1016/J.JID.2020.06.025
10.1111/JCMM.13959
10.3389/FCELL.2021.657472
10.3389/FIMMU.2012.00387
10.1186/BCR3676
10.1111/ODI.12363
10.3389/FIMMU.2019.02380
10.1186/S13046-019-1514-3
10.1016/J.TRECAN.2022.02.006
10.2147/CMAR.S314369
10.1074/JBC.M115.708446
10.3389/FIMMU.2019.01054
10.1093/LABMED/LMAB024
10.1016/J.JNEUROIM.2014.11.016
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Reviewed by: Lubka T. Roumenina, U1138 Centre de Recherche des Cordeliers (CRC) (INSERM), France; Maciej Cedzynski, Institute for Medical Biology (PAN), Poland
Edited by: Katy Rezvani, University of Texas MD Anderson Cancer Center, United States
This article was submitted to Cancer Immunity and Immunotherapy, a section of the journal Frontiers in Immunology
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References Hayes (B52) 2016; 9
West (B22) 2020; 295
Chen (B114) 2020; 66
Revel (B104) 2020; 9
Yuan (B113) 2020; 39
Ajona (B119) 2015; 21
Grailer (B20) 2013; 3
Satyam (B96) 2017; 198
Fishelson (B66) 2003; 40
Markiewski (B71) 2008; 9
Vlaicu (B38) 2019; 10
Piao (B75) 2018; 366
Roumenina (B29) 2019; 19
Tsujimura (B19) 1998; 330
Vidarsson (B51) 2014; 5
Kemper (B1) 2014; 61
Campa (B62) 2015; 3
Lee (B116) 2014; 13
Arbore (B17) 2016; 352
Zhang (B111) 2018; 8
Medler (B92) 2018; 34
Zhang (B105) 2021; 13
Towner (B59) 2026; 291
Zha (B97) 2019; 7
Dhillon (B48) 2015; 75
Reis (B10) 2017; 18
Wang (B83) 2021; 6
Ricklin (B28) 2016; 12
Reese (B80) 2020; 205
Macor (B70) 2014; 29
Kolev (B8) 2018; 37
Su (B124) 2020; 21
Haldar (B103) 2020; 117
Zhao (B67) 2009; 21
Elvington (B12) 2017; 127
Diebolder (B53) 2014; 343
Arbore (B5) 2017; 89
Grafals (B41) 2019; 2380
Weers (B46) 2011; 186
Bushey (B68) 2016; 15
Merle (B2) 2015; 6
Popeda (B126) 2021; 11
Liszewski (B11) 2013; 39
Ajona (B40) 2019; 85
Kolev (B13) 2020; 52
Amornsiripanitch (B69) 2010; 16
Davidson (B88) 2020; 31
Pio (B39) 2014; 772
Ling (B101) 2018; 360
Sogawa (B106) 2016; 115
Kochanek (B44) 2018; 9
Revel (B102) 2022
Kolev (B14) 2015; 42
Cardone (B15) 2010; 11
Aykut (B78) 2019; 574
Daugan (B117) 2021; 9
Shimazaki (B98) 2021; 44
West (B4) 2018; 36
Andrejeva (B99) 2017; 26
Noris (B3) 2013; 33
Rogers (B65) 2014; 59
Nabizadeh (B79) 2016; 196
Roumenina (B87) 2019; 7
Hillmen (B31) 2021; 384
Niyonzima (B16) 2021; 6
Macintyre (B23) 2013; 1
Sahin (B49) 2018; 100
Reis (B9) 2018; 18
Ajona (B118) 2013; 105
Carney (B57) 1985; 134
DeCordova (B64) 2019; 224
Hsu (B84) 2020; 39
Ioannou (B54) 2021; 22
Jiang (B72) 2021; 18
Beitia (B110) 2020; 10
Al-Rayahi (B73) 2021; 57
Shu (B91) 2020; 39
Touw van der (B82) 2013; 190
Friščić (B27) 2021; 54
Zent (B56) 2008; 32
Cao (B109) 2019; 91
Marshall (B55) 2017; 8
Merle (B7) 2015; 2
Laskowski (B37) 2020; 130
Kim (B42) 2004; 173
Oliveira-Ferrer (B94) 2020; 21
Gadwa (B81) 2021; 9
MacIejczyk (B60) 2011; 19
Lin (B63) 2021; 9
Huang (B107) 2021; 52
Li (B93) 2021; 258
Zhu (B121) 2021; 9
Thurman (B43) 2019; 10
Mao (B86) 2020; 10
Bouwens (B115) 2015; 278
Magrini (B77) 2021; 2
Ghebrehiwet (B100) 1997; 159
Chung (B112) 2014; 16
Dong (B123) 2021; 21
Bonavita (B36) 2015; 160
Arbore (B18) 2018; 9
Cho (B95) 2014; 6
Fishelson (B35) 2019; 10
Ajona (B120) 2017; 7
Daugan MvRevel (B85) 2021; 9
Hinshaw (B33) 2019; 79
Wang (B122) 2018; 8
El-Sahwi (B50) 2009; 102
Hsu (B47) 2010; 9
Wan (B128) 2012; 54
Macor (B34) 2018; 9
Liang (B125) 2021; 10
Cho (B127) 2014; 12
Tirosh (B89) 2016; 352
Kunz (B21) 2021; 12
Mak (B129) 2014; 6
Jackson (B76) 2021; 141
King (B25) 2019; 15
Fan (B45) 2019; 23
Mastellos (B26) 2019; 18
Ricklin (B32) 2017; 14
Xu (B90) 2020; 13
Zelek (B30) 2019; 114
Stallone (B74) 2020; 10
Chen (B108) 2013; 13
Kolev (B24) 2017
Kolev (B6) 2014; 14
Scolding (B58) 1989; 339
Zhang (B61) 2018; 14
References_xml – volume: 52
  start-page: 513
  year: 2020
  ident: B13
  article-title: Diapedesis-Induced Integrin Signaling via LFA-1 Facilitates Tissue Immunity by Inducing Intrinsic Complement C3 Expression in Immune Cells
  publication-title: Immunity
  doi: 10.1016/J.IMMUNI.2020.02.006
– volume: 54
  start-page: 1002
  year: 2021
  ident: B27
  article-title: The Complement System Drives Local Inflammatory Tissue Priming by Metabolic Reprogramming of Synovial Fibroblasts
  publication-title: Immunity
  doi: 10.1016/J.IMMUNI.2021.03.003
– volume: 29
  year: 2014
  ident: B70
  article-title: Bispecific Antibodies Targeting Tumor-Associated Antigens and Neutralizing Complement Regulators Increase the Efficacy of Antibody-Based Immunotherapy in Mice
  publication-title: Leukemia
  doi: 10.1038/leu.2014.185
– volume: 9
  year: 2021
  ident: B81
  article-title: Complement C3a and C5a Receptor Blockade Modulates Regulatory T Cell Conversion in Head and Neck Cancer
  publication-title: J Immunother Cancer
  doi: 10.1136/JITC-2021-002585
– volume: 8
  year: 2017
  ident: B55
  article-title: Therapeutic Antibodies: What Have We Learnt From Targeting CD20 and Where Are We Going
  publication-title: Front Immunol
  doi: 10.3389/FIMMU.2017.01245
– volume: 12
  start-page: 383
  year: 2016
  ident: B28
  article-title: Complement in Disease: A Defence System Turning Offensive
  publication-title: Nat Rev Nephrol
  doi: 10.1038/nrneph.2016.70
– volume: 5
  year: 2014
  ident: B51
  article-title: IgG Subclasses and Allotypes: From Structure to Effector Functions
  publication-title: Front Immunol
  doi: 10.3389/FIMMU.2014.00520
– volume: 6
  year: 2014
  ident: B95
  article-title: Autocrine Effects of Tumor-Derived Complement
  publication-title: Cell Rep
  doi: 10.1016/J.CELREP.2014.02.014
– volume: 16
  year: 2010
  ident: B69
  article-title: Complement Factor H Autoantibodies Are Associated With Early Stage NSCLC
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-10-0321
– volume: 12
  year: 2021
  ident: B21
  article-title: Complement Has Brains—Do Intracellular Complement and Immunometabolism Cooperate in Tissue Homeostasis and Behavior
  publication-title: Front Immunol
  doi: 10.3389/FIMMU.2021.629986
– volume: 9
  year: 2018
  ident: B34
  article-title: Complement as a Biological Tool to Control Tumor Growth
  publication-title: Front Immunol
  doi: 10.3389/FIMMU.2018.02203/BIBTEX
– volume: 91
  year: 2019
  ident: B109
  article-title: Straightforward and Highly Efficient Strategy for Hepatocellular Carcinoma Glycoprotein Biomarker Discovery Using a Nonglycopeptide-Based Mass Spectrometry Pipeline
  publication-title: Anal Chem
  doi: 10.1021/ACS.ANALCHEM.9B03074
– volume: 117
  year: 2020
  ident: B103
  article-title: Cancer Epithelia-Derived Mitochondrial DNA Is a Targetable Initiator of a Paracrine Signaling Loop That Confers Taxane Resistance
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/PNAS.1910952117/-/DCSUPPLEMENTAL
– volume: 2
  year: 2015
  ident: B7
  article-title: Complement System Part I – Molecular Mechanisms of Activation and Regulation
  publication-title: Front Immunol
  doi: 10.3389/FIMMU.2015.00262
– volume: 10
  start-page: 18400
  year: 2020
  ident: B74
  article-title: Modulation of Complement Activation by Pentraxin-3 in Prostate Cancer
  publication-title: Sci Rep
  doi: 10.1038/S41598-020-75376-Z
– volume: 10
  year: 2020
  ident: B110
  article-title: The Activation of Prothrombin Seems to Play an Earlier Role Than the Complement System in the Progression of Colorectal Cancer: A Mass Spectrometry Evaluation
  publication-title: Diagnostics
  doi: 10.3390/DIAGNOSTICS10121077
– volume: 9
  start-page: 891
  year: 2021
  ident: B117
  article-title: Complement C1s and C4d as Prognostic Biomarkers in Renal Cancer: Emergence of Noncanonical Functions of C1s
  publication-title: Cancer Immunol Res
  doi: 10.1158/2326-6066.CIR-20-0532
– volume: 9
  year: 2021
  ident: B63
  article-title: Sialylation of CD55 by ST3GAL1 Facilitates Immune Evasion in Cancer
  publication-title: Cancer Immunol Res
  doi: 10.1158/2326-6066.CIR-20-0203
– volume: 19
  start-page: 698
  year: 2019
  ident: B29
  article-title: Context-Dependent Roles of Complement in Cancer
  publication-title: Nat Rev Cancer
  doi: 10.1038/s41568-019-0210-0
– volume: 772
  year: 2014
  ident: B39
  article-title: The Role of Complement in Tumor Growth
  publication-title: Adv Exp Med Biol
  doi: 10.1007/978-1-4614-5915-6_11
– volume: 224
  year: 2019
  ident: B64
  article-title: Secretion of Functionally Active Complement Factor H Related Protein 5 (FHR5) by Primary Tumour Cells Derived From Glioblastoma Multiforme Patients
  publication-title: Immunobiology
  doi: 10.1016/J.IMBIO.2019.07.006
– volume: 9
  year: 2008
  ident: B71
  article-title: Modulation of the Antitumor Immune Response by Complement
  publication-title: Nat Immunol
  doi: 10.1038/ni.1655
– volume: 100
  start-page: 17
  year: 2018
  ident: B49
  article-title: A Phase I Dose-Escalation Study of IMAB362 (Zolbetuximab) in Patients With Advanced Gastric and Gastro-Oesophageal Junction Cancer
  publication-title: Eur J Cancer
  doi: 10.1016/J.EJCA.2018.05.007
– volume: 105
  year: 2013
  ident: B118
  article-title: Investigation of Complement Activation Product C4d as a Diagnostic and Prognostic Biomarker for Lung Cancer
  publication-title: JNCI: J Nat Canc Instit
  doi: 10.1093/jnci/djt205
– volume: 3
  year: 2015
  ident: B62
  article-title: Complement Factor H Antibodies From Lung Cancer Patients Induce Complement-Dependent Lysis of Tumor Cells, Suggesting a Novel Immunotherapeutic Strategy
  publication-title: Cancer Immunol Res
  doi: 10.1158/2326-6066.CIR-15-0122
– volume: 89
  start-page: 2
  year: 2017
  ident: B5
  article-title: Intracellular Complement – the Complosome – in Immune Cell Regulation
  publication-title: Mol Immunol
  doi: 10.1016/J.MOLIMM.2017.05.012
– volume: 13
  year: 2013
  ident: B108
  article-title: Profiling the Potential Tumor Markers of Pancreatic Ductal Adenocarcinoma Using 2D-DIGE and MALDI-TOF-MS: Up-Regulation of Complement C3 and Alpha-2-HS-Glycoprotein
  publication-title: Pancreatology
  doi: 10.1016/J.PAN.2013.03.010
– volume: 75
  year: 2015
  ident: B48
  article-title: Dinutuximab: First Global Approval
  publication-title: Drugs
  doi: 10.1007/S40265-015-0399-5
– volume: 343
  start-page: 1260
  year: 2014
  ident: B53
  article-title: Complement Is Activated by IgG Hexamers Assembled at the Cell Surface
  publication-title: Science (New York N Y)
  doi: 10.1126/SCIENCE.1248943
– volume: 1
  start-page: 1
  year: 2013
  ident: B23
  article-title: Activated Lymphocytes as a Metabolic Model for Carcinogenesis
  publication-title: Cancer Metab
  doi: 10.1186/2049-3002-1-5
– volume: 11
  start-page: 5097
  year: 2021
  ident: B126
  article-title: Reduced Expression of Innate Immunity-Related Genes in Lymph Node Metastases of Luminal Breast Cancer Patients
  publication-title: Sci Rep
  doi: 10.1038/S41598-021-84568-0
– volume: 19
  year: 2011
  ident: B60
  article-title: CD46 Expression is an Unfavorable Prognostic Factor in Breast Cancer Cases
  publication-title: Appl Immunohistochem Mol Morphol
  doi: 10.1097/PAI.0B013E31821A0BE9
– volume: 34
  start-page: 561
  year: 2018
  ident: B92
  article-title: Complement C5a Fosters Squamous Carcinogenesis and Limits T Cell Response to Chemotherapy
  publication-title: Cancer Cell
  doi: 10.1016/J.CCELL.2018.09.003
– volume: 7
  year: 2019
  ident: B87
  article-title: Tumor Cells Hijack Macrophage-Produced Complement C1q to Promote Tumor Growth
  publication-title: Cancer Immunol Res
  doi: 10.1158/2326-6066.CIR-18-0891
– volume: 8
  year: 2018
  ident: B122
  article-title: An Empirical Approach Leveraging Tumorgrafts to Dissect the Tumor Microenvironment in Renal Cell Carcinoma Identifies Missing Link to Prognostic Inflammatory Factors
  publication-title: Cancer Discov
  doi: 10.1158/2159-8290.CD-17-1246
– volume: 6
  start-page: 1
  year: 2021
  ident: B83
  article-title: PIWIL1 Governs the Crosstalk of Cancer Cell Metabolism and Immunosuppressive Microenvironment in Hepatocellular Carcinoma
  publication-title: Signal Transduct Target Ther
  doi: 10.1038/s41392-021-00485-8
– volume: 366
  year: 2018
  ident: B75
  article-title: Complement 5a Stimulates Macrophage Polarization and Contributes to Tumor Metastases of Colon Cancer
  publication-title: Exp Cell Res
  doi: 10.1016/J.YEXCR.2018.03.009
– volume: 31
  start-page: 107628
  year: 2020
  ident: B88
  article-title: Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth
  publication-title: Cell Rep
  doi: 10.1016/J.CELREP.2020.107628
– volume: 33
  start-page: 479
  year: 2013
  ident: B3
  article-title: Overview of Complement Activation and Regulation
  publication-title: Semin Nephrol
  doi: 10.1016/J.SEMNEPHROL.2013.08.001
– volume: 6
  start-page: 114
  year: 2014
  ident: B129
  article-title: Lost in translation: animal models and clinical trials in cancer treatment
  publication-title: Am J Transl Res
– volume: 114
  year: 2019
  ident: B30
  article-title: Compendium of Current Complement Therapeutics
  publication-title: Mol Immunol
  doi: 10.1016/J.MOLIMM.2019.07.030
– volume: 39
  start-page: 1
  year: 2020
  ident: B91
  article-title: C3a-C3aR Signaling Promotes Breast Cancer Lung Metastasis via Modulating Carcinoma Associated Fibroblasts
  publication-title: J Exp Clin Cancer Res
  doi: 10.1186/S13046-019-1515-2/FIGURES/6
– volume: 44
  year: 2021
  ident: B98
  article-title: Complement factor B regulates cellular senescence and is associated with poor prognosis in pancreatic cancer
  publication-title: Cell Oncol
  doi: 10.1007/S13402-021-00614-Z/FIGURES/6
– volume: 54
  start-page: 92
  year: 2012
  ident: B128
  article-title: Role of Complement 3 in TNF-α-Induced Mesenchymal Transition of Renal Tubular Epithelial Cells In Vitro
  publication-title: Molecular Biotechnology
  doi: 10.1007/S12033-012-9547-2
– volume: 127
  year: 2017
  ident: B12
  article-title: A C3(H20) Recycling Pathway is a Component of the Intracellular Complement System
  publication-title: J Clin Invest
  doi: 10.1172/JCI89412
– volume: 40
  year: 2003
  ident: B66
  article-title: Obstacles to Cancer Immunotherapy: Expression of Membrane Complement Regulatory Proteins (mCRPs) in Tumors
  publication-title: Mol Immunol
  doi: 10.1016/S0161-5890(03)00112-3
– volume: 14
  year: 2014
  ident: B6
  article-title: Complement-Tapping Into New Sites and Effector Systems
  publication-title: Nat Rev Immunol
  doi: 10.1038/NRI3761
– volume: 9
  start-page: 1
  year: 2018
  ident: B18
  article-title: Complement Receptor CD46 Co-Stimulates Optimal Human CD8+ T Cell Effector Function via Fatty Acid Metabolism
  publication-title: Nat Commun
  doi: 10.1038/s41467-018-06706-z
– volume: 14
  year: 2018
  ident: B61
  article-title: CD59: A Promising Target for Tumor Immunotherapy
  publication-title: Future Oncol
  doi: 10.2217/FON-2017-0498
– year: 2017
  ident: B24
  article-title: Keeping It All Going—Complement Meets Metabolism
  publication-title: Front. Immunol
  doi: 10.3389/FIMMU.2017.00001
– volume: 2
  start-page: 218
  year: 2021
  ident: B77
  article-title: Complement Activation Promoted by the Lectin Pathway Mediates C3aR-Dependent Sarcoma Progression and Immunosuppression
  publication-title: Nat Cancer
  doi: 10.1038/S43018-021-00173-0
– volume: 196
  year: 2016
  ident: B79
  article-title: The Complement C3a Receptor Contributes to Melanoma Tumorigenesis by Inhibiting Neutrophil and CD4+ T Cell Responses
  publication-title: J Immunol
  doi: 10.4049/JIMMUNOL.1600210
– volume: 37
  start-page: 85
  year: 2018
  ident: B8
  article-title: Targeting Complement-Mediated Immunoregulation for Cancer Immunotherapy
  publication-title: Semin Immunol
  doi: 10.1016/J.SMIM.2018.02.003
– volume: 21
  year: 2020
  ident: B124
  article-title: The Potential Role of Complement System in the Progression of Ovarian Clear Cell Carcinoma Inferred From the Gene Ontology-Based Immunofunctionome Analysis
  publication-title: Int J Mol Sci
  doi: 10.3390/IJMS21082824
– volume: 14
  start-page: 26
  year: 2017
  ident: B32
  article-title: The Renaissance of Complement Therapeutics
  publication-title: Nat Rev Nephrol
  doi: 10.1038/NRNEPH.2017.156
– volume: 360
  start-page: 558
  year: 2018
  ident: B101
  article-title: C1q Restrains Autoimmunity and Viral Infection by Regulating CD8+ T-Cell Metabolism
  publication-title: Science (New York N Y)
  doi: 10.1126/SCIENCE.AAO4555
– volume: 57
  year: 2021
  ident: B73
  article-title: Properdin Is a Modulator of Tumour Immunity in a Syngeneic Mouse Melanoma Model
  publication-title: Medicina
  doi: 10.3390/MEDICINA57020085
– volume: 173
  year: 2004
  ident: B42
  article-title: Complement C5a Receptor Is Essential for the Optimal Generation of Antiviral CD8+ T Cell Responses
  publication-title: J Immunol
  doi: 10.4049/JIMMUNOL.173.4.2524
– volume: 10
  year: 2021
  ident: B125
  article-title: Comparative Proteome Identifies Complement Component 3-Mediated Immune Response as Key Difference of Colon Adenocarcinoma and Rectal Adenocarcinoma
  publication-title: Front Oncol
  doi: 10.3389/FONC.2020.617890
– volume: 9
  year: 2020
  ident: B104
  article-title: Complement System: Promoter or Suppressor of Cancer Progression
  publication-title: Antibodies
  doi: 10.3390/ANTIB9040057
– volume: 12
  year: 2014
  ident: B127
  article-title: Complement Component 3 (C3) Is a Mediator of Epithelial-Mesenchymal Transition (EMT)
  publication-title: Blood
  doi: 10.1182/BLOOD.V124.21.1421.1421
– volume: 186
  year: 2011
  ident: B46
  article-title: Daratumumab, a Novel Therapeutic Human CD38 Monoclonal Antibody, Induces Killing of Multiple Myeloma and Other Hematological Tumors
  publication-title: J Immunol
  doi: 10.4049/JIMMUNOL.1003032
– volume: 134
  year: 1985
  ident: B57
  article-title: Elimination of Terminal Complement Intermediates From the Plasma Membrane of Nucleated Cells: The Rate of Disappearance Differs for Cells Carrying C5b-7 or C5b-8 or a Mixture of C5b-8 With a Limited Number of C5b-9
  publication-title: J Immunol
  doi: 10.4049/jimmunol.134.3.1804
– volume: 22
  year: 2021
  ident: B54
  article-title: Immunomodulatory Drugs for the Treatment of B Cell Malignancies
  publication-title: Int J Mol Sci
  doi: 10.3390/IJMS22168572
– volume: 9
  year: 2018
  ident: B44
  article-title: Complementing Cancer Metastasis
  publication-title: Front Immunol
  doi: 10.3389/FIMMU.2018.01629/BIBTEX
– volume: 258
  start-page: 2021
  year: 2021
  ident: B93
  article-title: Glioblastoma Cell-Derived lncRNA-Containing Exosomes Induce Microglia to Produce Complement C5, Promoting Chemotherapy Resistance
  publication-title: Cancer Immunol Res
  doi: 10.1158/2326-6066.CIR-21-0258
– volume: 190
  year: 2013
  ident: B82
  article-title: Cutting Edge: Receptors for C3a and C5a Modulate Stability of Alloantigen-Reactive Induced Regulatory T Cells
  publication-title: J Immunol
  doi: 10.4049/JIMMUNOL.1300847
– volume: 85
  year: 2019
  ident: B40
  article-title: Complement Anaphylatoxins C3a and C5a: Emerging Roles in Cancer Progression and Treatment
  publication-title: Semin Cell Dev Biol
  doi: 10.1016/J.SEMCDB.2017.11.023
– volume: 574
  year: 2019
  ident: B78
  article-title: The Fungal Mycobiome Promotes Pancreatic Oncogenesis via Activation of MBL
  publication-title: Nature
  doi: 10.1038/s41586-019-1608-2
– volume: 9
  year: 2021
  ident: B85
  article-title: Intracellular Factor H Drives Tumor Progression Independently of the Complement Cascade
  publication-title: Cancer Immunology Research
  doi: 10.1158/2326-6066.CIR-20-0787
– volume: 26
  start-page: 49
  year: 2017
  ident: B99
  article-title: Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors
  publication-title: Cell Metab
  doi: 10.1016/J.CMET.2017.06.004
– volume: 130
  year: 2020
  ident: B37
  article-title: Complement Factor H–deficient Mice Develop Spontaneous Hepatic Tumors
  publication-title: J Clin Invest
  doi: 10.1172/JCI135105
– volume: 61
  year: 2014
  ident: B1
  article-title: Complement Nomenclature 2014
  publication-title: Mol Immunol
  doi: 10.1016/J.MOLIMM.2014.07.004
– volume: 18
  start-page: 5
  year: 2018
  ident: B9
  article-title: Complement in cancer: Untangling an intricate relationship
  publication-title: Nat Rev Immunol
  doi: 10.1038/NRI.2017.97
– volume: 18
  start-page: 5
  year: 2017
  ident: B10
  article-title: Complement in Cancer: Untangling an Intricate Relationship
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri.2017.97
– volume: 9
  start-page: 1
  year: 2010
  ident: B47
  article-title: Complement Activation Mediates Cetuximab Inhibition of non-Small Cell Lung Cancer Tumor Growth In Vivo
  publication-title: Mol Cancer
  doi: 10.1186/1476-4598-9-139
– volume: 7
  start-page: 193
  year: 2019
  ident: B97
  article-title: Intracellular Activation of Complement C3 Leads to PD-L1 Antibody Treatment Resistance by Modulating Tumor-Associated Macrophages
  publication-title: Cancer Immunol Res
  doi: 10.1158/2326-6066.CIR-18-0272
– volume: 7
  start-page: 694
  year: 2017
  ident: B120
  article-title: A Combined PD-1/C5a Blockade Synergistically Protects Against Lung Cancer Growth and Metastasis
  publication-title: Cancer Discov
  doi: 10.1158/2159-8290.CD-16-1184
– volume: 59
  start-page: 203
  year: 2014
  ident: B65
  article-title: Complement in Monoclonal Antibody Therapy of Cancer
  publication-title: Immunol Res
  doi: 10.1007/S12026-014-8542-Z
– volume: 42
  year: 2015
  ident: B14
  article-title: Complement Regulates Nutrient Influx and Metabolic Reprogramming During Th1 Cell Responses
  publication-title: Immunity
  doi: 10.1016/J.IMMUNI.2015.05.024
– volume: 115
  year: 2016
  ident: B106
  article-title: Identification of a Novel Serum Biomarker for Pancreatic Cancer, C4b-Binding Protein α-Chain (C4BPA) by Quantitative Proteomic Analysis Using Tandem Mass Tags
  publication-title: Br J Cancer
  doi: 10.1038/bjc.2016.295
– volume: 15
  start-page: 919
  year: 2019
  ident: B25
  article-title: Intracellular Cytosolic Complement Component C3 Regulates Cytoprotective Autophagy in Pancreatic Beta Cells by Interaction With ATG16L1
  publication-title: Autophagy
  doi: 10.1080/15548627.2019.1580515
– volume: 9
  year: 2016
  ident: B52
  article-title: Fc Gamma Receptors: Glycobiology and Therapeutic Prospects
  publication-title: J Inflamm Res
  doi: 10.2147/JIR.S121233
– volume: 21
  year: 2009
  ident: B67
  article-title: Neutralization of Complement Regulatory Proteins CD55 and CD59 Augments Therapeutic Effect of Herceptin Against Lung Carcinoma Cells
  publication-title: Oncol Rep
  doi: 10.3892/OR_00000368
– volume: 8
  start-page: 315
  year: 2018
  ident: B111
  article-title: Anaphylatoxin C3a: A Potential Biomarker for Esophageal Cancer Diagnosis
  publication-title: Mol Clin Oncol
  doi: 10.3892/MCO.2017.1524
– volume: 79
  year: 2019
  ident: B33
  article-title: The Tumor Microenvironment Innately Modulates Cancer Progression
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-18-3962
– volume: 198
  year: 2017
  ident: B96
  article-title: Intracellular Activation of Complement 3 Is Responsible for Intestinal Tissue Damage During Mesenteric Ischemia
  publication-title: J Immunol
  doi: 10.4049/JIMMUNOL.1502287
– volume: 21
  start-page: 1
  year: 2021
  ident: B123
  article-title: Identification of C3 and FN1 as Potential Biomarkers Associated With Progression and Prognosis for Clear Cell Renal Cell Carcinoma
  publication-title: BMC Cancer
  doi: 10.1186/S12885-021-08818-0
– volume: 10
  year: 2019
  ident: B43
  article-title: Complement Therapeutics in Autoimmune Disease
  publication-title: Front Immunol
  doi: 10.3389/FIMMU.2019.00672
– volume: 39
  year: 2020
  ident: B84
  article-title: C3a Elicits Unique Migratory Responses in Immature Low-Density Neutrophils
  publication-title: Oncogene
  doi: 10.1038/s41388-020-1169-8
– volume: 6
  year: 2021
  ident: B16
  article-title: Mitochondrial C5aR1 Activity in Macrophages Controls IL-1β Production Underlying Sterile Inflammation
  publication-title: Sci Immunol
  doi: 10.1126/SCIIMMUNOL.ABF2489
– volume: 352
  year: 2016
  ident: B89
  article-title: Dissecting the Multicellular Ecosystem of Metastatic Melanoma by Single-Cell RNA-Seq
  publication-title: Science
  doi: 10.1126/SCIENCE.AAD0501
– volume: 11
  year: 2010
  ident: B15
  article-title: Complement Regulator CD46 Temporally Regulates Cytokine Production by Conventional and Unconventional T Cells
  publication-title: Nat Immunol
  doi: 10.1038/ni.1917
– volume: 36
  year: 2018
  ident: B4
  article-title: Complement and the Regulation of T Cell Responses
  publication-title: Annu Rev Immunol
  doi: 10.1146/ANNUREV-IMMUNOL-042617-053245
– volume: 384
  year: 2021
  ident: B31
  article-title: Pegcetacoplan versus Eculizumab in Paroxysmal Nocturnal Hemoglobinuria
  publication-title: New England Journal of Medicine
  doi: 10.1056/NEJMOA2029073/SUPPL_FILE/NEJMOA2029073_DATA-SHARING.PDF
– volume: 18
  start-page: 721
  year: 2021
  ident: B72
  article-title: Complement C3a Activates Osteoclasts by Regulating the PI3K/PDK1/SGK3 Pathway in Patients With Multiple Myeloma
  publication-title: Cancer Biol Med
  doi: 10.20892/J.ISSN.2095-3941.2020.0430
– volume: 330
  year: 1998
  ident: B19
  article-title: Molecular Cloning of a Murine Homologue of Membrane Cofactor Protein (CD46): Preferential Expression in Testicular Germ Cells
  publication-title: Biochem J
  doi: 10.1042/BJ3300163
– volume: 339
  year: 1989
  ident: B58
  article-title: Vesicular Removal by Oligodendrocytes of Membrane Attack Complexes Formed by Activated Complement
  publication-title: Nature
  doi: 10.1038/339620a0
– volume: 21
  start-page: 602
  year: 2020
  ident: B94
  article-title: Mechanisms of Tumor-Lymphatic Interactions in Invasive Breast and Prostate Carcinoma
  publication-title: Int J Mol Sci
  doi: 10.3390/IJMS21020602
– volume: 160
  year: 2015
  ident: B36
  article-title: PTX3 Is an Extrinsic Oncosuppressor Regulating Complement-Dependent Inflammation in Cancer
  publication-title: Cell
  doi: 10.1016/J.CELL.2015.01.004
– volume: 102
  year: 2009
  ident: B50
  article-title: In Vitro Activity of Pertuzumab in Combination With Trastuzumab in Uterine Serous Papillary Adenocarcinoma
  publication-title: Br J Cancer
  doi: 10.1038/sj.bjc.6605448
– volume: 13
  year: 2014
  ident: B116
  article-title: Identification of human complement factor B as a novel biomarker candidate for pancreatic ductal adenocarcinoma
  publication-title: J Proteo Res
  doi: 10.1021/PR5002719/SUPPL_FILE/PR5002719_SI_001.PDF
– volume: 295
  start-page: 68
  year: 2020
  ident: B22
  article-title: Complement and Human T Cell Metabolism: Location, Location, Location
  publication-title: Immunol Rev
  doi: 10.1111/IMR.12852
– volume: 352
  start-page: aad1210
  year: 2016
  ident: B17
  article-title: T Helper 1 Immunity Requires Complement-Driven NLRP3 Inflammasome Activity in CD4+ T Cells
  publication-title: Science
  doi: 10.1126/SCIENCE.AAD1210
– volume: 66
  year: 2020
  ident: B114
  article-title: The Clinical Significance of Serum MASP-2 and IDH1 in the Early Diagnosis of non-Small Cell Lung Cancer
  publication-title: Clin Lab
  doi: 10.7754/CLIN.LAB.2020.200249
– volume: 15
  year: 2016
  ident: B68
  article-title: A Therapeutic Antibody for Cancer, Derived From Single Human B Cells
  publication-title: Cell Rep
  doi: 10.1016/J.CELREP.2016.04.038
– volume: 159
  year: 1997
  ident: B100
  article-title: Evidence That the Two C1q Binding Membrane Proteins, Gc1q-R and Cc1q-R, Associate to Form a Complex
  publication-title: J Immunol
  doi: 10.4049/jimmunol.159.3.1429
– volume: 39
  year: 2013
  ident: B11
  article-title: Intracellular Complement Activation Sustains T Cell Homeostasis and Mediates Effector Differentiation
  publication-title: Immunity
  doi: 10.1016/J.IMMUNI.2013.10.018
– volume: 205
  year: 2020
  ident: B80
  article-title: Complement as Prognostic Biomarker and Potential Therapeutic Target in Renal Cell Carcinoma
  publication-title: J Immunol
  doi: 10.4049/JIMMUNOL.2000511
– volume: 13
  year: 2020
  ident: B90
  article-title: Activated Hepatic Stellate Cells (HSCs) Exert Immunosuppressive Effects in Hepatocellular Carcinoma by Producing Complement C3
  publication-title: Onco Targets Ther
  doi: 10.2147/OTT.S234920
– volume: 10
  year: 2020
  ident: B86
  article-title: Tumour Extracellular Vesicle-Derived Complement Factor H Promotes Tumorigenesis and Metastasis by Inhibiting Complement-Dependent Cytotoxicity of Tumour Cells
  publication-title: J Extracell Vesicles
  doi: 10.1002/JEV2.12031
– volume: 6
  year: 2015
  ident: B2
  article-title: Complement System Part II: Role in Immunity
  publication-title: Front Immunol
  doi: 10.3389/FIMMU.2015.00257
– volume: 32
  year: 2008
  ident: B56
  article-title: Direct and Complement Dependent Cytotoxicity in CLL Cells From Patients With High-Risk Early–Intermediate Stage Chronic Lymphocytic Leukemia (CLL) Treated With Alemtuzumab and Rituximab
  publication-title: Leuk Res
  doi: 10.1016/J.LEUKRES.2008.05.014
– volume: 18
  start-page: 707
  year: 2019
  ident: B26
  article-title: Clinical Promise of Next-Generation Complement Therapeutics
  publication-title: Nat Rev Drug Discov
  doi: 10.1038/S41573-019-0031-6
– volume: 10
  year: 2019
  ident: B35
  article-title: Complement C5b-9 and Cancer: Mechanisms of Cell Damage, Cancer Counteractions, and Approaches for Intervention
  publication-title: Front Immunol
  doi: 10.3389/FIMMU.2019.00752/BIBTEX
– volume: 141
  start-page: 404
  year: 2021
  ident: B76
  article-title: C3 Drives Inflammatory Skin Carcinogenesis Independently of C5
  publication-title: J Invest Dermatol
  doi: 10.1016/J.JID.2020.06.025
– volume: 23
  year: 2019
  ident: B45
  article-title: Complement C3a Promotes Proliferation, Migration and Stemness in Cutaneous Squamous Cell Carcinoma
  publication-title: J Cell Mol Med
  doi: 10.1111/JCMM.13959
– volume: 9
  year: 2021
  ident: B121
  article-title: Targeting the Complement Pathway in Malignant Glioma Microenvironments
  publication-title: Front Cell Dev Biol
  doi: 10.3389/FCELL.2021.657472
– volume: 3
  year: 2013
  ident: B20
  article-title: Regulatory Effects of C5a on IL-17a, IL-17F, and IL-23
  publication-title: Front Immunol
  doi: 10.3389/FIMMU.2012.00387
– volume: 16
  start-page: R63
  year: 2014
  ident: B112
  article-title: Novel Serum Protein Biomarker Panel Revealed by Mass Spectrometry and its Prognostic Value in Breast Cancer
  publication-title: Breast Cancer Res
  doi: 10.1186/BCR3676
– volume: 21
  start-page: 899
  year: 2015
  ident: B119
  article-title: Complement activation product C4d in oral and oropharyngeal squamous cell carcinoma
  publication-title: Oral Disease
  doi: 10.1111/ODI.12363
– volume: 2380
  year: 2019
  ident: B41
  article-title: The Role of Complement in Organ Transplantation
  publication-title: Front Immunol
  doi: 10.3389/FIMMU.2019.02380
– volume: 39
  start-page: 1
  year: 2020
  ident: B113
  article-title: Complement C3 Overexpression Activates JAK2/STAT3 Pathway and Correlates With Gastric Cancer Progression
  publication-title: J Exp Clin Cancer Res
  doi: 10.1186/S13046-019-1514-3
– year: 2022
  ident: B102
  article-title: C1q+ macrophages: passengers or drivers of cancer progression
  publication-title: Trends in Cancer
  doi: 10.1016/J.TRECAN.2022.02.006
– volume: 13
  year: 2021
  ident: B105
  article-title: A Preliminary Study of the Complement Component 1q Levels in Predicting the Efficacy of Combined Immunotherapy in Patients With Lung Cancer
  publication-title: Cancer Manag Res
  doi: 10.2147/CMAR.S314369
– volume: 291
  year: 2026
  ident: B59
  article-title: Complement Membrane Attack and Tumorigenesis: A SYSTEMS BIOLOGY APPROACH *
  publication-title: J Bio Chem
  doi: 10.1074/JBC.M115.708446
– volume: 10
  year: 2019
  ident: B38
  article-title: Role of C5b-9 and RGC-32 in Cancer
  publication-title: Front Immunol
  doi: 10.3389/FIMMU.2019.01054
– volume: 52
  year: 2021
  ident: B107
  article-title: MALDI-TOF-MS Analysis in the Discovery and Identification of the Serum Peptide Pattern of Pancreatic Ductal Adenocarcinoma
  publication-title: Lab Med
  doi: 10.1093/LABMED/LMAB024
– volume: 278
  year: 2015
  ident: B115
  article-title: Complement Activation in Glioblastoma Multiforme Pathophysiology: Evidence From Serum Levels and Presence of Complement Activation Products in Tumor Tissue
  publication-title: J Neuroimmunol
  doi: 10.1016/J.JNEUROIM.2014.11.016
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Snippet The role of complement in cancer has received increasing attention over the last decade. Recent studies provide compelling evidence that complement accelerates...
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SubjectTerms biomarkers
cancer
extracellular complement
Immunology
intracellular complement
therapy
tumor microenvironment
Title Inside-Out of Complement in Cancer
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https://pubmed.ncbi.nlm.nih.gov/PMC9291441
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Volume 13
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