Oxidative stress in retinal pigment epithelium impairs stem cells: a vicious cycle in age-related macular degeneration

Aging, chronic oxidative stress, and inflammation are major pathogenic factors in the development and progression of age-related macular degeneration (AMD) with the loss of retinal pigment epithelium (RPE). The human RPE contains a subpopulation of progenitors ( i.e. , RPE stem cells—RPESCs) whose r...

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Bibliographic Details
Published in:	Molecular and cellular biochemistry Vol. 477; no. 1; pp. 67 - 77
Main Authors:	Lazzarini, Raffaella, Nicolai, Michele, Lucarini, Guendalina, Pirani, Vittorio, Mariotti, Cesare, Bracci, Massimo, Mattioli-Belmonte, Monica
Format:	Journal Article
Language:	English
Published:	New York Springer US 01.01.2022 Springer Springer Nature B.V
Subjects:	Age related diseases Aging Biochemistry Biomedical and Life Sciences Cardiology Cell Line Epithelium Eye diseases Functional morphology Galactosidase Homeostasis Humans Hydrogen peroxide Hydrogen Peroxide - pharmacology Inflammation Interleukin 6 Interleukin-6 - metabolism Life Sciences Macular degeneration Macular Degeneration - metabolism Medical Biochemistry Microenvironments Molecular modelling Oncology Oxidative Stress Paracrine signalling Pathogenesis Phenotypes Progenitor cells Retina Retinal pigment epithelium Retinal Pigment Epithelium - metabolism Senescence Stem cells Stem Cells - metabolism Superoxide Superoxide dismutase Superoxide Dismutase - metabolism β-Galactosidase Oxidative stress Inflammation Senescence-associated secretory phenotype (SASP) Age-related macular degeneration (AMD) Retinal pigment epithelium Stem cells
ISSN:	0300-8177, 1573-4919, 1573-4919
Online Access:	Get full text
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