Mediators of neutrophil function in children with protracted bacterial bronchitis

Protracted bacterial bronchitis (PBB) is a common and treatable cause of chronic wet cough in children in which the mechanisms are not understood. This study investigates the IL-1 pathway and a neutrophil gene expression signature in PBB. BAL was collected from children in an experimental cohort (n...

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Bibliographic Details
Published in:	Chest Vol. 146; no. 4; p. 1013
Main Authors:	Baines, Katherine J, Upham, John W, Yerkovich, Stephanie T, Chang, Anne B, Marchant, Julie M, Carroll, Melanie, Simpson, Jodie L, Gibson, Peter G
Format:	Journal Article
Language:	English
Published:	United States 01.10.2014
Subjects:	alpha-Defensins - genetics alpha-Defensins - metabolism Bacterial Infections - genetics Bacterial Infections - metabolism Blotting, Western Bronchitis - genetics Bronchitis - metabolism Bronchoalveolar Lavage Fluid - immunology Child Child, Preschool Enzyme-Linked Immunosorbent Assay Female Humans Infant Interleukin 1 Receptor Antagonist Protein - genetics Interleukin 1 Receptor Antagonist Protein - metabolism Interleukin-1 - genetics Interleukin-1 - metabolism Interleukin-1beta - genetics Interleukin-1beta - metabolism Male Neutrophils - physiology Real-Time Polymerase Chain Reaction
ISSN:	1931-3543, 1931-3543
Online Access:	Get more information
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