RNA-Seq Transcriptome Analysis of Peripheral Blood From Cattle Infected With Mycobacterium bovis Across an Experimental Time Course
Bovine tuberculosis, caused by infection with members of the Mycobacterium tuberculosis complex, particularly Mycobacterium bovis , is a major endemic disease affecting cattle populations worldwide, despite the implementation of stringent surveillance and control programs in many countries. The deve...
Uloženo v:
| Vydáno v: | Frontiers in veterinary science Ročník 8; s. 662002 |
|---|---|
| Hlavní autoři: | , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
Frontiers Media S.A
28.05.2021
|
| Témata: | |
| ISSN: | 2297-1769, 2297-1769 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Bovine tuberculosis, caused by infection with members of the
Mycobacterium tuberculosis
complex, particularly
Mycobacterium bovis
, is a major endemic disease affecting cattle populations worldwide, despite the implementation of stringent surveillance and control programs in many countries. The development of high-throughput functional genomics technologies, including RNA sequencing, has enabled detailed analysis of the host transcriptome to
M. bovis
infection, particularly at the macrophage and peripheral blood level. In the present study, we have analysed the transcriptome of bovine whole peripheral blood samples collected at −1 week pre-infection and +1, +2, +6, +10, and +12 weeks post-infection time points. Differentially expressed genes were catalogued and evaluated at each post-infection time point relative to the −1 week pre-infection time point and used for the identification of putative candidate host transcriptional biomarkers for
M. bovis
infection. Differentially expressed gene sets were also used for examination of cellular pathways associated with the host response to
M. bovis
infection, construction of
de novo
gene interaction networks enriched for host differentially expressed genes, and time-series analyses to identify functionally important groups of genes displaying similar patterns of expression across the infection time course. A notable outcome of these analyses was identification of a 19-gene transcriptional biosignature of infection consisting of genes increased in expression across the time course from +1 week to +12 weeks post-infection. |
|---|---|
| AbstractList | Bovine tuberculosis, caused by infection with members of the
Mycobacterium tuberculosis
complex, particularly
Mycobacterium bovis
, is a major endemic disease affecting cattle populations worldwide, despite the implementation of stringent surveillance and control programs in many countries. The development of high-throughput functional genomics technologies, including RNA sequencing, has enabled detailed analysis of the host transcriptome to
M. bovis
infection, particularly at the macrophage and peripheral blood level. In the present study, we have analysed the transcriptome of bovine whole peripheral blood samples collected at −1 week pre-infection and +1, +2, +6, +10, and +12 weeks post-infection time points. Differentially expressed genes were catalogued and evaluated at each post-infection time point relative to the −1 week pre-infection time point and used for the identification of putative candidate host transcriptional biomarkers for
M. bovis
infection. Differentially expressed gene sets were also used for examination of cellular pathways associated with the host response to
M. bovis
infection, construction of
de novo
gene interaction networks enriched for host differentially expressed genes, and time-series analyses to identify functionally important groups of genes displaying similar patterns of expression across the infection time course. A notable outcome of these analyses was identification of a 19-gene transcriptional biosignature of infection consisting of genes increased in expression across the time course from +1 week to +12 weeks post-infection. Bovine tuberculosis, caused by infection with members of the Mycobacterium tuberculosis complex, particularly Mycobacterium bovis, is a major endemic disease affecting cattle populations worldwide, despite the implementation of stringent surveillance and control programs in many countries. The development of high-throughput functional genomics technologies, including RNA sequencing, has enabled detailed analysis of the host transcriptome to M. bovis infection, particularly at the macrophage and peripheral blood level. In the present study, we have analysed the transcriptome of bovine whole peripheral blood samples collected at −1 week pre-infection and +1, +2, +6, +10, and +12 weeks post-infection time points. Differentially expressed genes were catalogued and evaluated at each post-infection time point relative to the −1 week pre-infection time point and used for the identification of putative candidate host transcriptional biomarkers for M. bovis infection. Differentially expressed gene sets were also used for examination of cellular pathways associated with the host response to M. bovis infection, construction of de novo gene interaction networks enriched for host differentially expressed genes, and time-series analyses to identify functionally important groups of genes displaying similar patterns of expression across the infection time course. A notable outcome of these analyses was identification of a 19-gene transcriptional biosignature of infection consisting of genes increased in expression across the time course from +1 week to +12 weeks post-infection. Bovine tuberculosis, caused by infection with members of the Mycobacterium tuberculosis complex, particularly Mycobacterium bovis, is a major endemic disease affecting cattle populations worldwide, despite the implementation of stringent surveillance and control programs in many countries. The development of high-throughput functional genomics technologies, including RNA sequencing, has enabled detailed analysis of the host transcriptome to M. bovis infection, particularly at the macrophage and peripheral blood level. In the present study, we have analysed the transcriptome of bovine whole peripheral blood samples collected at -1 week pre-infection and +1, +2, +6, +10, and +12 weeks post-infection time points. Differentially expressed genes were catalogued and evaluated at each post-infection time point relative to the -1 week pre-infection time point and used for the identification of putative candidate host transcriptional biomarkers for M. bovis infection. Differentially expressed gene sets were also used for examination of cellular pathways associated with the host response to M. bovis infection, construction of de novo gene interaction networks enriched for host differentially expressed genes, and time-series analyses to identify functionally important groups of genes displaying similar patterns of expression across the infection time course. A notable outcome of these analyses was identification of a 19-gene transcriptional biosignature of infection consisting of genes increased in expression across the time course from +1 week to +12 weeks post-infection.Bovine tuberculosis, caused by infection with members of the Mycobacterium tuberculosis complex, particularly Mycobacterium bovis, is a major endemic disease affecting cattle populations worldwide, despite the implementation of stringent surveillance and control programs in many countries. The development of high-throughput functional genomics technologies, including RNA sequencing, has enabled detailed analysis of the host transcriptome to M. bovis infection, particularly at the macrophage and peripheral blood level. In the present study, we have analysed the transcriptome of bovine whole peripheral blood samples collected at -1 week pre-infection and +1, +2, +6, +10, and +12 weeks post-infection time points. Differentially expressed genes were catalogued and evaluated at each post-infection time point relative to the -1 week pre-infection time point and used for the identification of putative candidate host transcriptional biomarkers for M. bovis infection. Differentially expressed gene sets were also used for examination of cellular pathways associated with the host response to M. bovis infection, construction of de novo gene interaction networks enriched for host differentially expressed genes, and time-series analyses to identify functionally important groups of genes displaying similar patterns of expression across the infection time course. A notable outcome of these analyses was identification of a 19-gene transcriptional biosignature of infection consisting of genes increased in expression across the time course from +1 week to +12 weeks post-infection. |
| Author | McLoughlin, Kirsten E. MacHugh, David E. Vordermeier, H. Martin Villarreal-Ramos, Bernardo Correia, Carolina N. Whelan, Adam O. Gordon, Stephen V. Rue-Albrecht, Kevin Magee, David A. Browne, John A. Nalpas, Nicolas C. Gormley, Eamonn |
| AuthorAffiliation | 1 Animal Genomics Laboratory, UCD School of Agriculture and Food Science, UCD College of Health and Agricultural Sciences, University College Dublin , Dublin , Ireland 3 UCD School of Veterinary Medicine, UCD College of Health and Agricultural Sciences, University College Dublin , Dublin , Ireland 2 TB Immunology and Vaccinology Team, Department of Bacteriology, Animal and Plant Health Agency , Weybridge , United Kingdom 4 UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin , Dublin , Ireland |
| AuthorAffiliation_xml | – name: 4 UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin , Dublin , Ireland – name: 3 UCD School of Veterinary Medicine, UCD College of Health and Agricultural Sciences, University College Dublin , Dublin , Ireland – name: 2 TB Immunology and Vaccinology Team, Department of Bacteriology, Animal and Plant Health Agency , Weybridge , United Kingdom – name: 1 Animal Genomics Laboratory, UCD School of Agriculture and Food Science, UCD College of Health and Agricultural Sciences, University College Dublin , Dublin , Ireland |
| Author_xml | – sequence: 1 givenname: Kirsten E. surname: McLoughlin fullname: McLoughlin, Kirsten E. – sequence: 2 givenname: Carolina N. surname: Correia fullname: Correia, Carolina N. – sequence: 3 givenname: John A. surname: Browne fullname: Browne, John A. – sequence: 4 givenname: David A. surname: Magee fullname: Magee, David A. – sequence: 5 givenname: Nicolas C. surname: Nalpas fullname: Nalpas, Nicolas C. – sequence: 6 givenname: Kevin surname: Rue-Albrecht fullname: Rue-Albrecht, Kevin – sequence: 7 givenname: Adam O. surname: Whelan fullname: Whelan, Adam O. – sequence: 8 givenname: Bernardo surname: Villarreal-Ramos fullname: Villarreal-Ramos, Bernardo – sequence: 9 givenname: H. Martin surname: Vordermeier fullname: Vordermeier, H. Martin – sequence: 10 givenname: Eamonn surname: Gormley fullname: Gormley, Eamonn – sequence: 11 givenname: Stephen V. surname: Gordon fullname: Gordon, Stephen V. – sequence: 12 givenname: David E. surname: MacHugh fullname: MacHugh, David E. |
| BookMark | eNp9kstuEzEUhkeoiJbSB2DnJZukvo49G6QQtTRSuQiCWFoez3Hjamac2k7UrHlxnKRClAUrH5_Ldy76X1cnYxihqt4SPGVMNZduCzlNKaZkWtcUY_qiOqO0kRMi6-bkL_u0ukjpHmNMBJdM4VfVKeOEckrZWfXr2-fZ5Ds8oGU0Y7LRr3MYAM1G0--STyg49BWKdwXR9OhDH0KHrmMY0Nzk3ANajA5shg799HmFPu1saE35R78ZUBu2hTCzMaSEzIiuHtclMMCYC2pZDDQPm5jgTfXSmT7BxdN7Xv24vlrObya3Xz4u5rPbieWc5rILxcI1FnPWCseEtB0QW9OOsZqD4tI6aWVHBXXcAgPlcItNo2xLWN0qYOfV4sjtgrnX6zKKiTsdjNcHR4h32sTsbQ8aG9F0RircNYpzLBQIYyUITriogdrCen9krTftAJ0tS5UDPYM-j4x-pe_CVivSMCZ4Abx7AsTwsIGU9eCThb43I4RN0lRwLGmtalpSyTH1cMkI7k8bgvVeC_qgBb3Xgj5qodTIf2qszyb7sJ_G9_-p_A2Bb70U |
| CitedBy_id | crossref_primary_10_3389_fmicb_2022_1041314 crossref_primary_10_33188_vetheder_1449573 crossref_primary_10_1016_j_anscip_2025_04_152 crossref_primary_10_1128_iai_00313_21 crossref_primary_10_3389_fvets_2025_1558799 crossref_primary_10_1186_s12864_024_10574_x crossref_primary_10_1007_s13721_025_00558_6 crossref_primary_10_1038_s42003_025_07846_x crossref_primary_10_1016_j_tube_2022_102235 crossref_primary_10_1038_s41598_024_67001_0 crossref_primary_10_1038_s42003_025_07883_6 crossref_primary_10_1016_j_micres_2021_126853 crossref_primary_10_1016_j_anscip_2025_04_203 |
| Cites_doi | 10.3389/fimmu.2014.00396 10.1016/j.vetmic.2005.11.031 10.1172/JCI45444 10.1007/s00011-006-5136-9 10.1155/2015/124762 10.1007/s00018-016-2422-8 10.1371/journal.pone.0077789 10.1371/journal.pbio.1000598 10.1016/j.tem.2012.11.005 10.3389/fmicb.2018.02820 10.1016/j.tube.2017.11.008 10.1016/j.jinf.2018.08.010 10.1038/19546 10.1016/j.molimm.2011.11.011 10.1016/j.imbio.2008.12.005 10.1186/1741-7007-8-84 10.1039/9781788016421-00105 10.1214/ss/1177011454 10.1016/j.jinf.2008.02.007 10.1111/j.2517-6161.1995.tb02031.x 10.1093/infdis/jiy033 10.1007/978-3-319-64371-7_7 10.1038/31159 10.1016/j.vetimm.2010.12.002 10.1016/j.vetmic.2005.11.029 10.1186/gb-2010-11-3-r25 10.1371/journal.pone.0030626 10.1371/journal.pone.0041066 10.1093/bioinformatics/btt656 10.1186/s13620-019-0140-x 10.1016/j.cell.2014.11.024 10.1099/mgen.0.000163 10.1038/ni.3096 10.1016/j.vetimm.2014.02.009 10.1086/376559 10.1111/zph.12684 10.1093/bioinformatics/bti1022 10.1111/imr.12269 10.3389/fendo.2018.00214 10.1016/j.tube.2018.01.002 10.1152/physiolgenomics.00084.2011 10.1093/bioinformatics/bth283 10.1371/journal.pone.0239938 10.1054/tube.2000.0279 10.1146/annurev-animal-021815-111311 10.1186/1471-2105-7-191 10.1186/1471-2164-8-400 10.1073/pnas.1130426100 10.1038/s41598-019-51328-0 10.5588/ijtld.14.0060 10.1371/journal.pone.0028958 10.1111/2049-632X.12108 10.1016/j.cellsig.2014.01.015 10.1016/S1473-3099(16)30139-6 10.1093/bioinformatics/btp616 10.1038/nrg3244 10.1016/j.immuni.2019.03.020 10.1371/journal.pone.0162220 10.1016/j.vaccine.2013.11.045 10.1016/j.tube.2020.102006 10.1128/IAI.69.8.5182-5185.2001 10.1038/s41423-020-0502-z 10.15252/emmm.201505790 10.1016/j.cmpb.2013.05.025 10.1093/bioinformatics/bti525 10.1016/j.immuni.2008.05.012 10.1080/00365540600868305 10.1186/gb-2009-10-4-r42 10.1046/j.1365-2567.2000.00944.x 10.1086/515585 10.1016/j.molmed.2014.01.006 10.3389/fgene.2014.00035 10.1128/microbiolspec.TBTB2-0010-2016 10.1016/j.rvsc.2018.10.016 10.1128/CVI.00551-16 10.4049/jimmunol.172.10.6251 10.1016/j.vaccine.2012.02.018 10.1084/jem.20171704 10.1016/j.vaccine.2016.07.055 10.4049/jimmunol.178.6.3767 10.1146/annurev-immunol-032712-095939 10.1038/nrmicro2321 10.1371/journal.pone.0142270 10.1093/nar/gkn201 10.1128/IAI.00057-06 10.1292/jvms.65.193 10.1038/nrdp.2016.76 10.1016/j.chom.2016.11.002 10.4049/jimmunol.169.11.6343 10.1128/microbiolspec.TBTB2-0018-2016 10.1186/1471-2164-9-447 10.1111/j.1462-5822.2004.00489.x 10.3389/fvets.2018.00109 10.1007/s10875-008-9222-3 10.1074/jbc.M113.472183 10.1016/j.smim.2015.03.002 10.1016/S2213-2600(16)00048-5 10.1177/0300985817705177 10.1016/j.rvsc.2014.03.017 10.1016/j.molimm.2007.06.357 10.1128/IAI.61.8.3111-3116.1993 10.1146/annurev-immunol-032712-100022 10.1177/1753425911426591 10.1016/S0928-8244(03)00223-2 10.3892/mmr.2015.3721 10.3389/fimmu.2020.01470 10.1089/aid.2006.22.45 10.3389/fgene.2018.00278 10.1038/cmi.2018.5 10.1073/pnas.1121072109 10.1111/tbed.12561 10.1172/JCI117702 10.1093/bioinformatics/bts635 10.1093/bioinformatics/btt703 10.1128/IAI.00858-06 10.1128/9781555819569.ch11 10.1038/srep13629 10.3389/fimmu.2012.00040 10.1038/s41467-019-09955-8 10.1002/eji.200737855 10.1038/mi.2011.7 10.1038/nature09247 10.1111/imr.12268 10.1186/1471-2164-12-611 10.3389/fimmu.2017.00118 10.1093/femspd/ftz053 10.1098/rstb.2013.0427 10.1016/j.imlet.2019.10.012 10.3855/jidc.9554 10.1016/j.vaccine.2012.07.086 10.1177/0300985819844815 10.1186/1471-2164-15-1021 10.1098/rstb.2009.0097 10.1371/journal.ppat.1006410 10.1111/j.1399-0039.2006.00599.x 10.1016/j.vetmic.2015.01.026 10.1128/genomeA.00157-17 10.1590/S0074-02762009000700018 10.5588/ijtld.17.0855 10.1182/blood-2004-12-4623 |
| ContentType | Journal Article |
| Copyright | Copyright © 2021 McLoughlin, Correia, Browne, Magee, Nalpas, Rue-Albrecht, Whelan, Villarreal-Ramos, Vordermeier, Gormley, Gordon and MacHugh. Copyright © 2021 McLoughlin, Correia, Browne, Magee, Nalpas, Rue-Albrecht, Whelan, Villarreal-Ramos, Vordermeier, Gormley, Gordon and MacHugh. 2021 McLoughlin, Correia, Browne, Magee, Nalpas, Rue-Albrecht, Whelan, Villarreal-Ramos, Vordermeier, Gormley, Gordon and MacHugh |
| Copyright_xml | – notice: Copyright © 2021 McLoughlin, Correia, Browne, Magee, Nalpas, Rue-Albrecht, Whelan, Villarreal-Ramos, Vordermeier, Gormley, Gordon and MacHugh. – notice: Copyright © 2021 McLoughlin, Correia, Browne, Magee, Nalpas, Rue-Albrecht, Whelan, Villarreal-Ramos, Vordermeier, Gormley, Gordon and MacHugh. 2021 McLoughlin, Correia, Browne, Magee, Nalpas, Rue-Albrecht, Whelan, Villarreal-Ramos, Vordermeier, Gormley, Gordon and MacHugh |
| DBID | AAYXX CITATION 7X8 5PM DOA |
| DOI | 10.3389/fvets.2021.662002 |
| DatabaseName | CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE - Academic |
| DatabaseTitleList | CrossRef MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Veterinary Medicine |
| EISSN | 2297-1769 |
| ExternalDocumentID | oai_doaj_org_article_0a59da780d9844058e5ac7e541456e2c PMC8193354 10_3389_fvets_2021_662002 |
| GrantInformation_xml | Рfundername: Wellcome Trust grantid: 097429/Z/11/Z Рfundername: Ci̻ncia sem Fronteiras grantid: BEX-13070-13-4 Рfundername: Department of Agriculture, Food and the Marine, Ireland grantid: 17/RD/US-ROI/52; RSF 06 405 Рfundername: Seventh Framework Programme grantid: KBBE-211602-MACROSYS Рfundername: Science Foundation Ireland grantid: SFI/08/IN.1/B2038; SFI/15/IA/3154 Рfundername: Department for Environment, Food and Rural Affairs, UK Government grantid: SE3224 |
| GroupedDBID | 53G 5VS 9T4 AAFWJ AAYXX ACGFS ADBBV ADRAZ AFPKN ALMA_UNASSIGNED_HOLDINGS AOIJS BCNDV CITATION GROUPED_DOAJ HYE KQ8 M48 M~E OK1 PGMZT RPM 7X8 5PM |
| ID | FETCH-LOGICAL-c442t-17205f9c043b5f357cde1c62d3364e847cf7c7d252f4ce3e8f0b0a98cb136b8e3 |
| IEDL.DBID | DOA |
| ISICitedReferencesCount | 10 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000660068700001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 2297-1769 |
| IngestDate | Fri Oct 03 12:51:08 EDT 2025 Tue Sep 30 15:29:21 EDT 2025 Fri Sep 05 06:38:02 EDT 2025 Sat Nov 29 06:10:09 EST 2025 Tue Nov 18 22:42:23 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Language | English |
| License | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c442t-17205f9c043b5f357cde1c62d3364e847cf7c7d252f4ce3e8f0b0a98cb136b8e3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Adam O. Whelan, Biomedical Sciences, Defence Science and Technology Laboratory, Salisbury, United Kingdom Kevin Rue-Albrecht, MRC WIMM Centre for Computational Biology, University of Oxford, Oxford, United Kingdom This article was submitted to Veterinary Infectious Diseases, a section of the journal Frontiers in Veterinary Science Bernardo Villarreal-Ramos and H. Martin Vordermeier have positions as Ser Cymru II Professors of Immunology at the Institute of Biological, Environmental & Rural Sciences, Aberystwyth University, Aberystwyth, United Kingdom Edited by: Federico Blanco, Institute of Biotechnology, National Institute of Agricultural Technology (INTA), Argentina Reviewed by: Marta Alonso-Hearn, Animalien Osasuna, NEIKER-Instituto Vasco de Investigación y Desarrollo Agrario, Spain; Paola M. Boggiatto, National Animal Disease Center (USDA ARS), United States Present address: Nicolas C. Nalpas, Quantitative Proteomics and Proteome Centre Tübingen, Interfaculty Institute for Cell Biology, University of Tübingen, Tübingen, Germany |
| OpenAccessLink | https://doaj.org/article/0a59da780d9844058e5ac7e541456e2c |
| PMID | 34124223 |
| PQID | 2540726862 |
| PQPubID | 23479 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_0a59da780d9844058e5ac7e541456e2c pubmedcentral_primary_oai_pubmedcentral_nih_gov_8193354 proquest_miscellaneous_2540726862 crossref_primary_10_3389_fvets_2021_662002 crossref_citationtrail_10_3389_fvets_2021_662002 |
| PublicationCentury | 2000 |
| PublicationDate | 2021-05-28 |
| PublicationDateYYYYMMDD | 2021-05-28 |
| PublicationDate_xml | – month: 05 year: 2021 text: 2021-05-28 day: 28 |
| PublicationDecade | 2020 |
| PublicationTitle | Frontiers in veterinary science |
| PublicationYear | 2021 |
| Publisher | Frontiers Media S.A |
| Publisher_xml | – name: Frontiers Media S.A |
| References | Maertzdorf (B39) 2016; 8 Blankley (B35) 2014; 369 Estévez (B71) 2020; 11 Meade (B104) 2007; 8 Kanipe (B10) 2020; 125 Bar-Joseph (B136) 2004; 20 Nibbering (B96) 1993; 61 A (B129) 2012; 49 Garnier (B2) 2003; 100 Jorgensen (B140) 2012; 44 O'Garra (B12) 2013; 31 Kramer (B57) 2014; 30 Harling (B120) 2019; 16 Malone (B45) 2017; 5 Yu (B108) 2019; 77 Neill (B143) 2001; 81 Robinson (B55) 2010; 11 Huynh (B116) 2018; 215 Eugen-Olsen (B78) 2002; 6 Alonso-Hearn (B105) 2019; 9 Sahu (B135) 2017; 13 Galietti (B76) 2001; 43 Cliff (B67) 2015; 264 Blanco (B30) 2012; 7 Hossain (B63) 2003; 65 Correia (B37) 2017; 8 Maertzdorf (B66) 2012; 109 Bar-Joseph (B137) 2012; 13 Zhang (B85) 1995; 95 Perry (B6) 2009; 364 Ghorpade (B134) 2013; 288 More (B23) 2015; 176 Sweeney (B69) 2016; 4 Rosas-Taraco (B73) 2006; 22 Domingo-Gonzalez (B95) 2016; 4 Turner (B115) 2002; 169 Awuh (B19) 2017; 74 Klepp (B32) 2019; 122 Gerszten (B86) 1999; 398 Harding (B127) 2010; 8 Whelan (B46) 2012; 30 B49 Dupnik (B83) 2018; 22 Malone (B4) 2017; 1019 McLoughlin (B31) 2014; 5 Berry (B65) 2010; 466 Perry (B5) 2002 Salguero (B44) 2017; 64 Oh (B138) 2014; 5 Dutta (B130) 2012; 7 Keller (B126) 2006; 74 Martinot (B20) 2018; 55 Vordermeier (B27) 2016; 4 Sawant (B89) 2007; 75 Widdison (B90) 2008; 45 Rogatsky (B110) 2006; 68 Killick (B28) 2011; 12 Liao (B132) 2011; 121 Pagan (B21) 2018; 36 Rhodes (B34) 2000; 99 Hoshino (B72) 2004; 172 Benjamini (B56) 1995; 57 Redford (B113) 2011; 4 Shankar (B74) 2014; 70 Dobin (B51) 2013; 29 Ernst (B60) 2005; 1 Djoba (B80) 2008; 56 Krupa (B97) 2015; 2015 Araujo (B81) 2018; 12 Faherty (B38) 2019 Meade (B102) 2008; 9 Bai (B118) 2014; 26 de (B16) 2009; 214 Chaussabel (B36) 2015; 27 Cambier (B17) 2014; 159 O'Kane (B82) 2008; 38 Durinck (B54) 2005; 21 Chen (B109) 2020; 217 Ostrowski (B79) 2006; 38 Gormley (B25) 2006; 112 Daya (B84) 2014; 15 Weijer (B75) 2005; 106 Harriff (B128) 2012; 3 Metcalfe (B42) 2016; 34 Aranday-Cortes (B29) 2012; 7 Wang (B125) 2003; 39 Lindenau (B107) 2014; 18 Wang (B121) 2015; 16 Agresti (B58) 1992; 7 Nalpas (B48) 2015; 5 Cassidy (B144) 2006; 112 Cassidy (B22) 2019; 56 Andersson (B93) 2012; 18 Hmama (B114) 2015; 264 Robinson (B53) 2010; 26 Ernst (B59) 2006; 7 Chai (B123) 2019; 10 Schorey (B18) 2016 Chaussabel (B61) 2008; 29 Correia (B64) 2018; 9 Juffermans (B77) 2001; 69 Johnson (B47) 2008; 36 Taraktsoglou (B103) 2011; 140 Wiarda (B33) 2020; 15 Steele (B7) 1995 Malone (B101) 2018; 4 Almeida (B91) 2009; 104 Xin (B100) 2019; 78 Ouyang (B117) 2019; 50 Lee (B92) 2009; 29 More (B24) 2019; 72 Dimitrakopoulou (B141) 2013; 111 Busillo (B111) 2013; 24 Blanc (B139) 2011; 9 Domingo (B13) 2014; 97 Brites (B3) 2018; 9 Olea-Popelka (B9) 2017; 17 Huang (B94) 2013; 8 Kasahara (B98) 1998; 178 O'Kane (B88) 2007; 178 Yaqubi (B133) 2015; 12 Cole (B1) 1998; 393 Alessandri (B87) 2006; 55 Franco (B122) 2017; 21 Waters (B8) 2012; 30 Pai (B14) 2016; 2 Blankley (B68) 2016; 11 Jones (B43) 2017; 24 Chai (B124) 2020; 17 Wang (B119) 2018; 108 Ma (B106) 2003; 188 Luciano (B11) 2020; 67 Liao (B52) 2014; 30 Scriba (B15) 2016; 4 Godaly (B99) 2005; 7 Xiong (B131) 2018; 217 Dean (B41) 2015; 10 Maslove (B142) 2014; 20 Waters (B145) 2014; 159 Chaussabel (B62) 2010; 8 Leong (B70) 2018; 109 D'Attilio (B112) 2018; 9 Zimin (B50) 2009; 10 Allen (B26) 2018; 5 Dean (B40) 2014; 32 |
| References_xml | – volume: 5 start-page: 396 year: 2014 ident: B31 article-title: RNA-seq transcriptional profiling of peripheral blood leukocytes from cattle infected with Mycobacterium bovis publication-title: Front Immunol doi: 10.3389/fimmu.2014.00396 – volume-title: Investing in Animal Health Research to Alleviate Poverty. year: 2002 ident: B5 – volume: 112 start-page: 151 year: 2006 ident: B144 article-title: The pathogenesis and pathology of bovine tuberculosis with insights from studies of tuberculosis in humans and laboratory animal models publication-title: Vet Microbiol. doi: 10.1016/j.vetmic.2005.11.031 – volume: 121 start-page: 2736 year: 2011 ident: B132 article-title: Kruppel-like factor 4 regulates macrophage polarization publication-title: J Clin Invest. doi: 10.1172/JCI45444 – volume: 6 start-page: 686 year: 2002 ident: B78 article-title: The serum level of soluble urokinase receptor is elevated in tuberculosis patients and predicts mortality during treatment: a community study from Guinea-Bissau publication-title: Int J Tuberc Lung Dis. – volume: 55 start-page: 528 year: 2006 ident: B87 article-title: Concentrations of CXCL8, CXCL9 and sTNFR1 in plasma of patients with pulmonary tuberculosis undergoing treatment publication-title: Inflamm Res. doi: 10.1007/s00011-006-5136-9 – volume: 2015 start-page: 124762 year: 2015 ident: B97 article-title: Binding of CXCL8/IL-8 to Mycobacterium tuberculosis modulates the innate immune response publication-title: Mediators Inflamm. doi: 10.1155/2015/124762 – volume: 74 start-page: 1625 year: 2017 ident: B19 article-title: Molecular basis of mycobacterial survival in macrophages publication-title: Cell Mol Life Sci. doi: 10.1007/s00018-016-2422-8 – volume: 8 start-page: e77789 year: 2013 ident: B94 article-title: NF-kappaB repressing factor inhibits chemokine synthesis by peripheral blood mononuclear cells and alveolar macrophages in active pulmonary tuberculosis publication-title: PLoS ONE. doi: 10.1371/journal.pone.0077789 – volume: 9 start-page: e1000598 year: 2011 ident: B139 article-title: Host defense against viral infection involves interferon mediated down-regulation of sterol biosynthesis publication-title: PLoS Biol. doi: 10.1371/journal.pbio.1000598 – volume: 24 start-page: 109 year: 2013 ident: B111 article-title: The five Rs of glucocorticoid action during inflammation: ready, reinforce, repress, resolve, and restore publication-title: Trends Endocrinol Metab. doi: 10.1016/j.tem.2012.11.005 – volume: 9 start-page: 2820 year: 2018 ident: B3 article-title: A new phylogenetic framework for the animal-adapted Mycobacterium tuberculosis complex publication-title: Front Microbiol. doi: 10.3389/fmicb.2018.02820 – volume: 108 start-page: 118 year: 2018 ident: B119 article-title: Mycobacterium tuberculosis infection induces IL-10 gene expression by disturbing histone deacetylase 6 and histone deacetylase 11 equilibrium in macrophages publication-title: Tuberculosis. doi: 10.1016/j.tube.2017.11.008 – volume: 78 start-page: 292 year: 2019 ident: B100 article-title: Serum level of IL-8 is associated with reversion of QuantiFERON-TB gold in-tube tests publication-title: J Infect. doi: 10.1016/j.jinf.2018.08.010 – volume: 398 start-page: 718 year: 1999 ident: B86 article-title: MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions publication-title: Nature. doi: 10.1038/19546 – volume: 49 start-page: 655 year: 2012 ident: B129 article-title: ESAT-6 induced COX-2 expression involves coordinated interplay between PI3K and MAPK signaling publication-title: Mol Immunol. doi: 10.1016/j.molimm.2011.11.011 – volume: 214 start-page: 526 year: 2009 ident: B16 article-title: The many niches and strategies used by pathogenic mycobacteria for survival within host macrophages publication-title: Immunobiology. doi: 10.1016/j.imbio.2008.12.005 – volume: 8 start-page: 84 year: 2010 ident: B62 article-title: Assessing the human immune system through blood transcriptomics publication-title: BMC Biol. doi: 10.1186/1741-7007-8-84 – start-page: 105 volume-title: MicroRNAs in Diseases and Disorders: Emerging Therapeutic Targets year: 2019 ident: B38 article-title: CHAPTER 4: MicroRNAs and mycobacterial infections in humans and domestic animals doi: 10.1039/9781788016421-00105 – volume: 7 start-page: 131 year: 1992 ident: B58 article-title: A survey of exact inference for contingency tables publication-title: Statist Sci. doi: 10.1214/ss/1177011454 – volume: 56 start-page: 340 year: 2008 ident: B80 article-title: Immune parameters as markers of tuberculosis extent of disease and early prediction of anti-tuberculosis chemotherapy response publication-title: J Infect. doi: 10.1016/j.jinf.2008.02.007 – volume: 57 start-page: 289 year: 1995 ident: B56 article-title: Controlling the false discovery rate - a practical and powerful approach to multiple testing publication-title: J R Stat Soc Ser B Methodol. doi: 10.1111/j.2517-6161.1995.tb02031.x – volume: 217 start-page: 1267 year: 2018 ident: B131 article-title: Novel function of cyclooxygenase-2: suppressing mycobacteria by promoting autophagy via the protein kinase B/mammalian target of rapamycin pathway publication-title: J Infect Dis. doi: 10.1093/infdis/jiy033 – volume: 1019 start-page: 135 year: 2017 ident: B4 article-title: Mycobacterium tuberculosis complex members adapted to wild and domestic animals publication-title: Adv Exp Med Biol. doi: 10.1007/978-3-319-64371-7_7 – volume: 393 start-page: 537 year: 1998 ident: B1 article-title: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence publication-title: Nature. doi: 10.1038/31159 – ident: B49 – volume: 140 start-page: 130 year: 2011 ident: B103 article-title: Transcriptional profiling of immune genes in bovine monocyte-derived macrophages exposed to bacterial antigens publication-title: Vet Immunol Immunopathol. doi: 10.1016/j.vetimm.2010.12.002 – volume: 112 start-page: 171 year: 2006 ident: B25 article-title: Diagnosis of Mycobacterium bovis infection in cattle by use of the gamma-interferon (Bovigam) assay publication-title: Vet Microbiol. doi: 10.1016/j.vetmic.2005.11.029 – volume: 11 start-page: R25 year: 2010 ident: B55 article-title: A scaling normalization method for differential expression analysis of RNA-seq data publication-title: Genome Biol. doi: 10.1186/gb-2010-11-3-r25 – volume: 7 start-page: e30626 year: 2012 ident: B29 article-title: Transcriptional profiling of disease-induced host responses in bovine tuberculosis and the identification of potential diagnostic biomarkers publication-title: PLoS ONE. doi: 10.1371/journal.pone.0030626 – volume: 7 start-page: e41066 year: 2012 ident: B30 article-title: Transcriptional response of peripheral blood mononuclear cells from cattle infected with Mycobacterium bovis publication-title: PLoS ONE doi: 10.1371/journal.pone.0041066 – volume: 30 start-page: 923 year: 2014 ident: B52 article-title: featureCounts: an efficient general purpose program for assigning sequence reads to genomic features publication-title: Bioinformatics. doi: 10.1093/bioinformatics/btt656 – volume: 72 start-page: 3 year: 2019 ident: B24 article-title: Can bovine TB be eradicated from the Republic of Ireland? Could this be achieved by 2030? publication-title: Ir Vet J. doi: 10.1186/s13620-019-0140-x – volume: 159 start-page: 1497 year: 2014 ident: B17 article-title: Host evasion and exploitation schemes of Mycobacterium tuberculosis publication-title: Cell doi: 10.1016/j.cell.2014.11.024 – volume: 4 start-page: e000163 year: 2018 ident: B101 article-title: Comparative 'omics analyses differentiate Mycobacterium tuberculosis and Mycobacterium bovis and reveal distinct macrophage responses to infection with the human and bovine tubercle bacilli publication-title: Microb Genom. doi: 10.1099/mgen.0.000163 – volume: 16 start-page: 237 year: 2015 ident: B121 article-title: Mycobacterium tuberculosis suppresses innate immunity by coopting the host ubiquitin system publication-title: Nat Immunol. doi: 10.1038/ni.3096 – volume: 159 start-page: 113 year: 2014 ident: B145 article-title: Relevance of bovine tuberculosis research to the understanding of human disease: historical perspectives, approaches, immunologic mechanisms publication-title: Vet Immunol Immunopathol. doi: 10.1016/j.vetimm.2014.02.009 – volume: 188 start-page: 349 year: 2003 ident: B106 article-title: Association between interleukin-8 gene alleles and human susceptibility to tuberculosis disease publication-title: J Infect Dis. doi: 10.1086/376559 – volume: 67 start-page: 97 year: 2020 ident: B11 article-title: Human zoonotic tuberculosis and livestock exposure in low- and middle-income countries: a systematic review identifying challenges in laboratory diagnosis publication-title: Zoonoses Public Health. doi: 10.1111/zph.12684 – volume: 1 start-page: i159 year: 2005 ident: B60 article-title: Clustering short time series gene expression data publication-title: Bioinformatics. doi: 10.1093/bioinformatics/bti1022 – volume: 264 start-page: 88 year: 2015 ident: B67 article-title: The human immune response to tuberculosis and its treatment: a view from the blood publication-title: Immunol Rev. doi: 10.1111/imr.12269 – volume: 9 start-page: 214 year: 2018 ident: B112 article-title: Tuberculosis, the disrupted immune-endocrine response and the potential thymic repercussion as a contributing factor to disease physiopathology publication-title: Front Endocrinol. doi: 10.3389/fendo.2018.00214 – volume: 109 start-page: 41 year: 2018 ident: B70 article-title: Existing blood transcriptional classifiers accurately discriminate active tuberculosis from latent infection in individuals from south India publication-title: Tuberculosis. doi: 10.1016/j.tube.2018.01.002 – volume: 44 start-page: 595 year: 2012 ident: B140 article-title: Transcriptional profiling of the bovine hepatic response to experimentally induced E. coli mastitis publication-title: Physiol Genomics. doi: 10.1152/physiolgenomics.00084.2011 – volume: 20 start-page: 2493 year: 2004 ident: B136 article-title: Analyzing time series gene expression data publication-title: Bioinformatics. doi: 10.1093/bioinformatics/bth283 – volume: 15 start-page: e0239938 year: 2020 ident: B33 article-title: Severity of bovine tuberculosis is associated with innate immune-biased transcriptional signatures of whole blood in early weeks after experimental Mycobacterium bovis infection publication-title: PLoS ONE. doi: 10.1371/journal.pone.0239938 – volume: 81 start-page: 79 year: 2001 ident: B143 article-title: Pathogenesis of tuberculosis in cattle publication-title: Tuberculosis. doi: 10.1054/tube.2000.0279 – volume: 4 start-page: 87 year: 2016 ident: B27 article-title: Bovine tuberculosis in cattle: vaccines, DIVA tests, and host biomarker discovery publication-title: Annu Rev Anim Biosci. doi: 10.1146/annurev-animal-021815-111311 – volume: 7 start-page: 191 year: 2006 ident: B59 article-title: STEM: a tool for the analysis of short time series gene expression data publication-title: BMC Bioinformatics. doi: 10.1186/1471-2105-7-191 – volume: 8 start-page: 400 year: 2007 ident: B104 article-title: Innate gene repression associated with Mycobacterium bovis infection in cattle: toward a gene signature of disease publication-title: BMC Genomics. doi: 10.1186/1471-2164-8-400 – volume: 100 start-page: 7877 year: 2003 ident: B2 article-title: The complete genome sequence of Mycobacterium bovis publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1130426100 – volume: 9 start-page: 14845 year: 2019 ident: B105 article-title: RNA-Seq analysis of ileocecal valve and peripheral blood from Holstein cattle infected with Mycobacterium avium subsp. paratuberculosis revealed dysregulation of the CXCL8/IL8 signaling pathway publication-title: Sci Rep. doi: 10.1038/s41598-019-51328-0 – volume: 18 start-page: 952 year: 2014 ident: B107 article-title: Cytokine gene polymorphisms are associated with susceptibility to tuberculosis in an Amerindian population publication-title: Int J Tuberc Lung Dis. doi: 10.5588/ijtld.14.0060 – volume: 7 start-page: e28958 year: 2012 ident: B130 article-title: The stress-response factor SigH modulates the interaction between Mycobacterium tuberculosis and host phagocytes publication-title: PLoS ONE. doi: 10.1371/journal.pone.0028958 – volume: 70 start-page: 110 year: 2014 ident: B74 article-title: HIV-Mycobacterium tuberculosis co-infection: a 'danger-couple model' of disease pathogenesis publication-title: Pathog Dis. doi: 10.1111/2049-632X.12108 – volume: 26 start-page: 942 year: 2014 ident: B118 article-title: TLR3 regulates mycobacterial RNA-induced IL-10 production through the PI3K/AKT signaling pathway publication-title: Cell Signal. doi: 10.1016/j.cellsig.2014.01.015 – volume: 17 start-page: e21 year: 2017 ident: B9 article-title: Zoonotic tuberculosis in human beings caused by Mycobacterium bovis – a call for action publication-title: Lancet Infect Dis. doi: 10.1016/S1473-3099(16)30139-6 – volume: 26 start-page: 139 year: 2010 ident: B53 article-title: edgeR: a Bioconductor package for differential expression analysis of digital gene expression data publication-title: Bioinformatics. doi: 10.1093/bioinformatics/btp616 – volume: 13 start-page: 552 year: 2012 ident: B137 article-title: Studying and modelling dynamic biological processes using time-series gene expression data publication-title: Nat Rev Genet. doi: 10.1038/nrg3244 – volume: 50 start-page: 871 year: 2019 ident: B117 article-title: IL-10 family cytokines IL-10 and IL-22: from basic science to clinical translation publication-title: Immunity. doi: 10.1016/j.immuni.2019.03.020 – volume: 11 start-page: e0162220 year: 2016 ident: B68 article-title: The transcriptional signature of active tuberculosis reflects symptom status in extra-pulmonary and pulmonary tuberculosis publication-title: PLoS ONE. doi: 10.1371/journal.pone.0162220 – volume: 32 start-page: 1304 year: 2014 ident: B40 article-title: Comparison of the immunogenicity and protection against bovine tuberculosis following immunization by BCG-priming and boosting with adenovirus or protein based vaccines publication-title: Vaccine. doi: 10.1016/j.vaccine.2013.11.045 – volume: 125 start-page: 102006 year: 2020 ident: B10 article-title: Mycobacterium bovis and you: a comprehensive look at the bacteria, its similarities to Mycobacterium tuberculosis, and its relationship with human disease publication-title: Tuberculosis. doi: 10.1016/j.tube.2020.102006 – volume: 69 start-page: 5182 year: 2001 ident: B77 article-title: Concurrent upregulation of urokinase plasminogen activator receptor and CD11b during tuberculosis and experimental endotoxemia publication-title: Infect Immun. doi: 10.1128/IAI.69.8.5182-5185.2001 – volume: 17 start-page: 901 year: 2020 ident: B124 article-title: New insights into the evasion of host innate immunity by Mycobacterium tuberculosis publication-title: Cell Mol Immunol doi: 10.1038/s41423-020-0502-z – volume: 8 start-page: 86 year: 2016 ident: B39 article-title: Concise gene signature for point-of-care classification of tuberculosis publication-title: EMBO Mol Med. doi: 10.15252/emmm.201505790 – volume: 111 start-page: 650 year: 2013 ident: B141 article-title: OLYMPUS: an automated hybrid clustering method in time series gene expression. Case study: host response after Influenza A (H1N1) infection publication-title: Comput Methods Programs Biomed. doi: 10.1016/j.cmpb.2013.05.025 – volume: 21 start-page: 3439 year: 2005 ident: B54 article-title: BioMart and Bioconductor: a powerful link between biological databases and microarray data analysis publication-title: Bioinformatics. doi: 10.1093/bioinformatics/bti525 – volume: 29 start-page: 150 year: 2008 ident: B61 article-title: A modular analysis framework for blood genomics studies: application to systemic lupus erythematosus publication-title: Immunity. doi: 10.1016/j.immuni.2008.05.012 – volume: 38 start-page: 1028 year: 2006 ident: B79 article-title: Elevated levels of soluble urokinase receptor in serum from mycobacteria infected patients: still looking for a marker of treatment efficacy publication-title: Scand J Infect Dis. doi: 10.1080/00365540600868305 – volume: 10 start-page: R42 year: 2009 ident: B50 article-title: A whole-genome assembly of the domestic cow, Bos taurus publication-title: Genome Biol doi: 10.1186/gb-2009-10-4-r42 – volume: 99 start-page: 195 year: 2000 ident: B34 article-title: Bovine tuberculosis: immune responses in the peripheral blood and at the site of active disease publication-title: Immunology. doi: 10.1046/j.1365-2567.2000.00944.x – volume: 178 start-page: 127 year: 1998 ident: B98 article-title: Expression of chemokines and induction of rapid cell death in human blood neutrophils by Mycobacterium tuberculosis publication-title: J Infect Dis doi: 10.1086/515585 – volume: 20 start-page: 204 year: 2014 ident: B142 article-title: Gene expression profiling in sepsis: timing, tissue, translational considerations publication-title: Trends Mol Med. doi: 10.1016/j.molmed.2014.01.006 – volume: 5 start-page: 35 year: 2014 ident: B138 article-title: The analytical landscape of static and temporal dynamics in transcriptome data publication-title: Front Genet. doi: 10.3389/fgene.2014.00035 – year: 2016 ident: B18 article-title: Innate immune responses to tuberculosis publication-title: Microbiol Spectr. doi: 10.1128/microbiolspec.TBTB2-0010-2016 – start-page: 169 volume-title: Mycobacterium bovis Infection in Animals and Humans year: 1995 ident: B7 article-title: Introduction (Part 2 Regional and Country Status Reports) – volume: 122 start-page: 7 year: 2019 ident: B32 article-title: Identification of bovine tuberculosis biomarkers to detect tuberculin skin test and IFNγ release assay false negative cattle publication-title: Res Vet Sci. doi: 10.1016/j.rvsc.2018.10.016 – volume: 24 start-page: e00551 year: 2017 ident: B43 article-title: Tuberculin skin testing boosts interferon gamma responses to DIVA reagents in Mycobacterium bovis-infected cattle publication-title: Clin Vaccine Immunol. doi: 10.1128/CVI.00551-16 – volume: 43 start-page: 249 year: 2001 ident: B76 article-title: p53 expression in cultured blood human monocytes infected with mycobacterial strains publication-title: Panminerva Med. – volume: 172 start-page: 6251 year: 2004 ident: B72 article-title: Mycobacterium tuberculosis-induced CXCR4 and chemokine expression leads to preferential X4 HIV-1 replication in human macrophages publication-title: J Immunol. doi: 10.4049/jimmunol.172.10.6251 – volume: 30 start-page: 2611 year: 2012 ident: B8 article-title: Bovine tuberculosis vaccine research: historical perspectives and recent advances publication-title: Vaccine. doi: 10.1016/j.vaccine.2012.02.018 – volume: 215 start-page: 1823 year: 2018 ident: B116 article-title: Bhlhe40 is an essential repressor of IL-10 during Mycobacterium tuberculosis infection publication-title: J Exp Med. doi: 10.1084/jem.20171704 – volume: 34 start-page: 4520 year: 2016 ident: B42 article-title: Protection associated with a TB vaccine is linked to increased frequency of Ag85A-specific CD4(+) T cells but no increase in avidity for Ag85A publication-title: Vaccine. doi: 10.1016/j.vaccine.2016.07.055 – volume: 178 start-page: 3767 year: 2007 ident: B88 article-title: Monocyte-dependent fibroblast CXCL8 secretion occurs in tuberculosis and limits survival of mycobacteria within macrophages publication-title: J Immunol. doi: 10.4049/jimmunol.178.6.3767 – volume: 31 start-page: 475 year: 2013 ident: B12 article-title: The immune response in tuberculosis publication-title: Annu Rev Immunol. doi: 10.1146/annurev-immunol-032712-095939 – volume: 8 start-page: 296 year: 2010 ident: B127 article-title: Regulation of antigen presentation by Mycobacterium tuberculosis: a role for Toll-like receptors publication-title: Nat Rev Microbiol. doi: 10.1038/nrmicro2321 – volume: 10 start-page: e0142270 year: 2015 ident: B41 article-title: Protection induced by simultaneous subcutaneous and endobronchial vaccination with BCG/BCG and BCG/adenovirus expressing antigen 85A against Mycobacterium bovis in cattle publication-title: PLoS ONE. doi: 10.1371/journal.pone.0142270 – volume: 36 start-page: W5 year: 2008 ident: B47 article-title: NCBI BLAST: a better web interface publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkn201 – volume: 74 start-page: 4295 year: 2006 ident: B126 article-title: Genetically determined susceptibility to tuberculosis in mice causally involves accelerated and enhanced recruitment of granulocytes publication-title: Infect Immun. doi: 10.1128/IAI.00057-06 – volume: 65 start-page: 193 year: 2003 ident: B63 article-title: Relation between reticulocyte count and characteristics of erythrocyte 5'-nucleotidase in dogs, cats, cattle and humans publication-title: J Vet Med Sci. doi: 10.1292/jvms.65.193 – volume: 2 start-page: 16076 year: 2016 ident: B14 article-title: Tuberculosis publication-title: Nat Rev Dis Primers. doi: 10.1038/nrdp.2016.76 – volume: 21 start-page: 59 year: 2017 ident: B122 article-title: The ubiquitin ligase Smurf1 functions in selective autophagy of Mycobacterium tuberculosis and anti-tuberculous host defense publication-title: Cell Host Microbe. doi: 10.1016/j.chom.2016.11.002 – volume: 169 start-page: 6343 year: 2002 ident: B115 article-title: In vivo IL-10 production reactivates chronic pulmonary tuberculosis in C57BL/6 mice publication-title: J Immunol. doi: 10.4049/jimmunol.169.11.6343 – volume: 4 year: 2016 ident: B95 article-title: Cytokines and chemokines in Mycobacterium tuberculosis infection publication-title: Microbiol Spectr. doi: 10.1128/microbiolspec.TBTB2-0018-2016 – volume: 9 start-page: 447 year: 2008 ident: B102 article-title: Antigen stimulation of peripheral blood mononuclear cells from Mycobacterium bovis infected cattle yields evidence for a novel gene expression program publication-title: BMC Genomics. doi: 10.1186/1471-2164-9-447 – volume: 7 start-page: 591 year: 2005 ident: B99 article-title: Mycobacterium bovis bacille Calmette Guerin infection of human neutrophils induces CXCL8 secretion by MyD88-dependent TLR2 and TLR4 activation publication-title: Cell Microbiol. doi: 10.1111/j.1462-5822.2004.00489.x – volume: 5 start-page: 109 year: 2018 ident: B26 article-title: Bovine tuberculosis in Britain and Ireland - a perfect storm? The confluence of potential ecological and epidemiological impediments to controlling a chronic infectious disease publication-title: Front Vet Sci. doi: 10.3389/fvets.2018.00109 – volume: 29 start-page: 46 year: 2009 ident: B92 article-title: Roles of reactive oxygen species in CXCL8 and CCL2 expression in response to the 30-kDa antigen of Mycobacterium tuberculosis publication-title: J Clin Immunol doi: 10.1007/s10875-008-9222-3 – volume: 288 start-page: 20592 year: 2013 ident: B134 article-title: Nitric oxide and KLF4 protein epigenetically modify class II transactivator to repress major histocompatibility complex II expression during Mycobacterium bovis bacillus Calmette-Guerin infection publication-title: J Biol Chem. doi: 10.1074/jbc.M113.472183 – volume: 27 start-page: 58 year: 2015 ident: B36 article-title: Assessment of immune status using blood transcriptomics and potential implications for global health publication-title: Semin Immunol. doi: 10.1016/j.smim.2015.03.002 – volume: 4 start-page: 213 year: 2016 ident: B69 article-title: Genome-wide expression for diagnosis of pulmonary tuberculosis: a multicohort analysis publication-title: Lancet Respir Med. doi: 10.1016/S2213-2600(16)00048-5 – volume: 55 start-page: 14 year: 2018 ident: B20 article-title: Microbial offense vs host defense: who controls the TB granuloma? publication-title: Vet Pathol. doi: 10.1177/0300985817705177 – volume: 97 start-page: S20 year: 2014 ident: B13 article-title: Pathology of bovine tuberculosis publication-title: Res Vet Sci. doi: 10.1016/j.rvsc.2014.03.017 – volume: 45 start-page: 740 year: 2008 ident: B90 article-title: Granulocyte chemotactic properties of M. tuberculosis versus M. bovis-infected bovine alveolar macrophages publication-title: Mol Immunol. doi: 10.1016/j.molimm.2007.06.357 – volume: 61 start-page: 3111 year: 1993 ident: B96 article-title: Interleukin-8 enhances nonoxidative intracellular killing of Mycobacterium fortuitum by human granulocytes publication-title: Infect Immun. doi: 10.1128/IAI.61.8.3111-3116.1993 – volume: 36 start-page: 639 year: 2018 ident: B21 article-title: The formation and function of granulomas publication-title: Annu Rev Immunol. doi: 10.1146/annurev-immunol-032712-100022 – volume: 18 start-page: 531 year: 2012 ident: B93 article-title: Mycobacterium bovis bacilli Calmette-Guerin regulates leukocyte recruitment by modulating alveolar inflammatory responses publication-title: Innate Immun. doi: 10.1177/1753425911426591 – volume: 39 start-page: 163 year: 2003 ident: B125 article-title: Gene expression profiling detects patterns of human macrophage responses following Mycobacterium tuberculosis infection publication-title: FEMS Immunol Med Microbiol. doi: 10.1016/S0928-8244(03)00223-2 – volume: 12 start-page: 2865 year: 2015 ident: B133 article-title: Transcription factor regulatory network for early lung immune response to tuberculosis in mice publication-title: Mol Med Rep. doi: 10.3892/mmr.2015.3721 – volume: 11 start-page: 1470 year: 2020 ident: B71 article-title: An RNA-seq based machine learning approach identifies latent tuberculosis patients with an active tuberculosis profile publication-title: Front Immunol. doi: 10.3389/fimmu.2020.01470 – volume: 22 start-page: 45 year: 2006 ident: B73 article-title: Mycobacterium tuberculosis upregulates coreceptors CCR5 and CXCR4 while HIV modulates CD14 favoring concurrent infection publication-title: AIDS Res Hum Retroviruses. doi: 10.1089/aid.2006.22.45 – volume: 9 start-page: 278 year: 2018 ident: B64 article-title: RNA sequencing (RNA-seq) reveals extremely low levels of reticulocyte-derived globin gene transcripts in peripheral blood from horses (Equus caballus) and cattle (Bos taurus) publication-title: Front Genet. doi: 10.3389/fgene.2018.00278 – volume: 16 start-page: 275 year: 2019 ident: B120 article-title: Constitutive STAT3 phosphorylation and IL-6/IL-10 co-expression are associated with impaired T-cell function in tuberculosis patients publication-title: Cell Mol Immunol. doi: 10.1038/cmi.2018.5 – volume: 109 start-page: 7853 year: 2012 ident: B66 article-title: Common patterns and disease-related signatures in tuberculosis and sarcoidosis publication-title: Proc Natl Acad Sci USA. doi: 10.1073/pnas.1121072109 – volume: 64 start-page: 1734 year: 2017 ident: B44 article-title: Differential cell composition and cytokine expression within lymph node granulomas from BCG-vaccinated and non-vaccinated cattle experimentally infected with Mycobacterium bovis publication-title: Transbound Emerg Dis doi: 10.1111/tbed.12561 – volume: 95 start-page: 586 year: 1995 ident: B85 article-title: Enhanced interleukin-8 release and gene expression in macrophages after exposure to Mycobacterium tuberculosis and its components publication-title: J Clin Invest. doi: 10.1172/JCI117702 – volume: 29 start-page: 15 year: 2013 ident: B51 article-title: STAR: ultrafast universal RNA-seq aligner publication-title: Bioinformatics. doi: 10.1093/bioinformatics/bts635 – volume: 30 start-page: 523 year: 2014 ident: B57 article-title: Causal analysis approaches in ingenuity pathway analysis publication-title: Bioinformatics. doi: 10.1093/bioinformatics/btt703 – volume: 75 start-page: 1870 year: 2007 ident: B89 article-title: Guinea pig neutrophils infected with Mycobacterium tuberculosis produce cytokines which activate alveolar macrophages in noncontact cultures publication-title: Infect Immun. doi: 10.1128/IAI.00858-06 – volume: 4 year: 2016 ident: B15 article-title: Human immunology of tuberculosis publication-title: Microbiol Spectr. doi: 10.1128/9781555819569.ch11 – volume: 5 start-page: 13629 year: 2015 ident: B48 article-title: RNA sequencing provides exquisite insight into the manipulation of the alveolar macrophage by tubercle bacilli publication-title: Sci Rep. doi: 10.1038/srep13629 – volume: 3 start-page: 40 year: 2012 ident: B128 article-title: Escape from the phagosome: the explanation for MHC-I processing of mycobacterial antigens? publication-title: Front Immunol. doi: 10.3389/fimmu.2012.00040 – volume: 10 start-page: 1973 year: 2019 ident: B123 article-title: A Mycobacterium tuberculosis surface protein recruits ubiquitin to trigger host xenophagy publication-title: Nat Commun. doi: 10.1038/s41467-019-09955-8 – volume: 38 start-page: 1321 year: 2008 ident: B82 article-title: Monocyte-dependent oncostatin M and TNF-alpha synergize to stimulate unopposed matrix metalloproteinase-1/3 secretion from human lung fibroblasts in tuberculosis publication-title: Eur J Immunol. doi: 10.1002/eji.200737855 – volume: 4 start-page: 261 year: 2011 ident: B113 article-title: The role of IL-10 in immune regulation during M. tuberculosis infection publication-title: Mucosal Immunol. doi: 10.1038/mi.2011.7 – volume: 466 start-page: 973 year: 2010 ident: B65 article-title: An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis publication-title: Nature. doi: 10.1038/nature09247 – volume: 264 start-page: 220 year: 2015 ident: B114 article-title: Immunoevasion and immunosuppression of the macrophage by Mycobacterium tuberculosis publication-title: Immunol Rev doi: 10.1111/imr.12268 – volume: 12 start-page: 611 year: 2011 ident: B28 article-title: Genome-wide transcriptional profiling of peripheral blood leukocytes from cattle infected with Mycobacterium bovis reveals suppression of host immune genes publication-title: BMC Genomics. doi: 10.1186/1471-2164-12-611 – volume: 8 start-page: 118 year: 2017 ident: B37 article-title: Circulating microRNAs as potential biomarkers of infectious disease publication-title: Front Immunol. doi: 10.3389/fimmu.2017.00118 – volume: 77 start-page: ftz053 year: 2019 ident: B108 article-title: Associations of six common functional polymorphisms in interleukins with tuberculosis: evidence from a meta-analysis publication-title: Pathog Dis. doi: 10.1093/femspd/ftz053 – volume: 369 start-page: 20130427 year: 2014 ident: B35 article-title: The application of transcriptional blood signatures to enhance our understanding of the host response to infection: the example of tuberculosis publication-title: Philos Trans R Soc Lond B Biol Sci. doi: 10.1098/rstb.2013.0427 – volume: 217 start-page: 1 year: 2020 ident: B109 article-title: Associations of polymorphisms in interleukins with tuberculosis: evidence from a meta-analysis publication-title: Immunol Lett. doi: 10.1016/j.imlet.2019.10.012 – volume: 12 start-page: 429 year: 2018 ident: B81 article-title: Diagnostic accuracy of combinations of serological biomarkers for identifying clinical tuberculosis publication-title: J Infect Dev Ctries. doi: 10.3855/jidc.9554 – volume: 30 start-page: 6294 year: 2012 ident: B46 article-title: Immunogenicity comparison of the intradermal or endobronchial boosting of BCG vaccinates with Ad5-85A publication-title: Vaccine. doi: 10.1016/j.vaccine.2012.07.086 – volume: 56 start-page: 508 year: 2019 ident: B22 article-title: TB or not TB? The granuloma is the question publication-title: Vet Pathol. doi: 10.1177/0300985819844815 – volume: 15 start-page: 1021 year: 2014 ident: B84 article-title: Using multi-way admixture mapping to elucidate TB susceptibility in the South African Coloured population publication-title: BMC Genomics. doi: 10.1186/1471-2164-15-1021 – volume: 364 start-page: 2643 year: 2009 ident: B6 article-title: The impacts of livestock diseases and their control on growth and development processes that are pro-poor publication-title: Philos Trans R Soc Lond B Biol Sci. doi: 10.1098/rstb.2009.0097 – volume: 13 start-page: e1006410 year: 2017 ident: B135 article-title: MicroRNA 26a (miR-26a)/KLF4 and CREB-C/EBPβ regulate innate immune signaling, the polarization of macrophages and the trafficking of Mycobacterium tuberculosis to lysosomes during infection publication-title: PLoS Pathog. doi: 10.1371/journal.ppat.1006410 – volume: 68 start-page: 1 year: 2006 ident: B110 article-title: Glucocorticoid modulation of cytokine signaling publication-title: Tissue Antigens. doi: 10.1111/j.1399-0039.2006.00599.x – volume: 176 start-page: 209 year: 2015 ident: B23 article-title: Understanding and managing bTB risk: perspectives from Ireland publication-title: Vet Microbiol. doi: 10.1016/j.vetmic.2015.01.026 – volume: 5 start-page: e00157 year: 2017 ident: B45 article-title: Updated reference genome sequence and annotation of Mycobacterium bovis AF2122/97 publication-title: Genome Announc. doi: 10.1128/genomeA.00157-17 – volume: 104 start-page: 1039 year: 2009 ident: B91 article-title: Anti-mycobacterial treatment reduces high plasma levels of CXC-chemokines detected in active tuberculosis by cytometric bead array publication-title: Mem Inst Oswaldo Cruz. doi: 10.1590/S0074-02762009000700018 – volume: 22 start-page: 950 year: 2018 ident: B83 article-title: Blood transcriptomic markers of Mycobacterium tuberculosis load in sputum publication-title: Int J Tuberc Lung Dis. doi: 10.5588/ijtld.17.0855 – volume: 106 start-page: 2761 year: 2005 ident: B75 article-title: A thrombomodulin mutation that impairs activated protein C generation results in uncontrolled lung inflammation during murine tuberculosis publication-title: Blood. doi: 10.1182/blood-2004-12-4623 |
| SSID | ssj0001547380 |
| Score | 2.2143056 |
| Snippet | Bovine tuberculosis, caused by infection with members of the
Mycobacterium tuberculosis
complex, particularly
Mycobacterium bovis
, is a major endemic disease... Bovine tuberculosis, caused by infection with members of the Mycobacterium tuberculosis complex, particularly Mycobacterium bovis, is a major endemic disease... |
| SourceID | doaj pubmedcentral proquest crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Enrichment Source Index Database |
| StartPage | 662002 |
| SubjectTerms | biomarker cattle gene expression host-pathogen interaction immune response time series Veterinary Science |
| Title | RNA-Seq Transcriptome Analysis of Peripheral Blood From Cattle Infected With Mycobacterium bovis Across an Experimental Time Course |
| URI | https://www.proquest.com/docview/2540726862 https://pubmed.ncbi.nlm.nih.gov/PMC8193354 https://doaj.org/article/0a59da780d9844058e5ac7e541456e2c |
| Volume | 8 |
| WOSCitedRecordID | wos000660068700001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2297-1769 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001547380 issn: 2297-1769 databaseCode: DOA dateStart: 20140101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2297-1769 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0001547380 issn: 2297-1769 databaseCode: M~E dateStart: 20140101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lj9MwELZgxYELggVEeayMxAkpbBLbsXPsrlqBRKsVj6W3yHHG2krbBLppJS5c-OPMOMmqucCFSw6JndiesedzPPMNY288rvoKkTHuTRITSat8ZEtnI6kh8aUQVRai-C8_6uXSrFb5xUGqL_IJ6-iBu4E7ja3KK6tNXOVGIrowoKzTQNmrVQapo9UXUc_BZqqLD5ZamP4YE3dh-anfQ0v03GnyLsvS4TfKYIgCX_8IZI5dJA9szvwhe9CDRT7tGvmI3YH6mB1fkgdLCKPli_5k_DH7_Wk5jT7DDx6MT1gKmg3wgXOEN55fYK1AInDNz8hdnc-3zYafBxZj_iE4ZUHFv63bK7746XCeBx7n3YaXzR7fMA394Lbms4OsAJxiSDhlvruBJ-zrfPbl_H3UJ1iInJRpGyF4iZXPXSxFqbxQ2lWQuCythMgkoN1yXjtdpSr10oEA4-MytrlxZSKy0oB4yo7qpoZnjHsvTAXWltIp6UWJqAeBZE7WPzHOqQmLh9EuXM8-TkkwrgvchZCAiiCgggRUdAKasLe3Vb531Bt_K3xGIrwtSKzZ4QbqUtHrUvEvXZqw14MCFDjL6OjE1tDs8EvEU5hSNM2E6ZFmjL44flKvrwJfN4IuIZR8_j-a-ILdp16T_0JqXrKjdruDV-ye27frm-0Ju6tX5iRMBbwufs3-AB17EWY |
| linkProvider | Directory of Open Access Journals |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=RNA-Seq+Transcriptome+Analysis+of+Peripheral+Blood+From+Cattle+Infected+With+Mycobacterium+bovis+Across+an+Experimental+Time+Course&rft.jtitle=Frontiers+in+veterinary+science&rft.au=Kirsten+E.+McLoughlin&rft.au=Carolina+N.+Correia&rft.au=John+A.+Browne&rft.au=David+A.+Magee&rft.date=2021-05-28&rft.pub=Frontiers+Media+S.A&rft.eissn=2297-1769&rft.volume=8&rft_id=info:doi/10.3389%2Ffvets.2021.662002&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_0a59da780d9844058e5ac7e541456e2c |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2297-1769&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2297-1769&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2297-1769&client=summon |