Circulating oncometabolite 2-hydroxyglutarate is a potential surrogate biomarker in patients with isocitrate dehydrogenase-mutant intrahepatic cholangiocarcinoma

Mutations in the IDH1 and IDH2 (IDH1/2) genes occur in approximately 20% of intrahepatic cholangiocarcinoma and lead to accumulation of 2-hydroxyglutarate (2HG) in the tumor tissue. However, it remains unknown whether IDH1/2 mutations can lead to high levels of 2HG circulating in the blood and wheth...

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Published in:	Clinical cancer research Vol. 20; no. 7; p. 1884
Main Authors:	Borger, Darrell R, Goyal, Lipika, Yau, Thomas, Poon, Ronnie T, Ancukiewicz, Marek, Deshpande, Vikram, Christiani, David C, Liebman, Hannah M, Yang, Hua, Kim, Hyeryun, Yen, Katharine, Faris, Jason E, Iafrate, A John, Kwak, Eunice L, Clark, Jeffrey W, Allen, Jill N, Blaszkowsky, Lawrence S, Murphy, Janet E, Saha, Supriya K, Hong, Theodore S, Wo, Jennifer Y, Ferrone, Cristina R, Tanabe, Kenneth K, Bardeesy, Nabeel, Straley, Kimberly S, Agresta, Sam, Schenkein, David P, Ellisen, Leif W, Ryan, David P, Zhu, Andrew X
Format:	Journal Article
Language:	English
Published:	United States 01.04.2014
Subjects:	Adult Aged Bile Duct Neoplasms - blood Bile Duct Neoplasms - genetics Bile Duct Neoplasms - pathology Bile Ducts, Intrahepatic - pathology Biomarkers, Tumor - blood Cholangiocarcinoma - blood Cholangiocarcinoma - genetics Cholangiocarcinoma - pathology Female Glutarates - blood Humans Isocitrate Dehydrogenase - blood Isocitrate Dehydrogenase - genetics Male Middle Aged Mutation
ISSN:	1078-0432, 1557-3265, 1557-3265
Online Access:	Get more information
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