Successful adjunctive use of bacteriophage therapy for treatment of multidrug-resistant Pseudomonas aeruginosa infection in a cystic fibrosis patient

Introduction We describe the use of bacteriophage therapy in a 26-year-old cystic fibrosis (CF) patient awaiting lung transplantation. Hospital Course The patient developed multidrug resistant (MDR) Pseudomonas aeruginosa pneumonia, persistent respiratory failure, and colistin-induced renal failure....

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Vydáno v:	Infection Ročník 47; číslo 4; s. 665 - 668
Hlavní autoři:	Law, Nancy, Logan, Cathy, Yung, Gordon, Furr, Carrie-Lynn Langlais, Lehman, Susan M., Morales, Sandra, Rosas, Francisco, Gaidamaka, Alexander, Bilinsky, Igor, Grint, Paul, Schooley, Robert T., Aslam, Saima
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Berlin/Heidelberg Springer Berlin Heidelberg 01.08.2019 Springer Nature B.V
Témata:	Antibiotics Antiinfectives and antibacterials Antimicrobial agents Case Report Colistin Cystic fibrosis Drug resistance Family Medicine General Practice Infectious Diseases Internal Medicine Intravenous administration Lung transplantation Lung transplants Medicine Medicine & Public Health Multidrug resistance Multidrug resistant organisms Patients Pneumonia Pseudomonas aeruginosa Renal failure Respiratory failure Therapy Transplantation Multidrug-resistant Antimicrobial Cystic fibrosis Antibiotic Bacteriophage therapy Lung transplant Multidrug-resistant Pseudomonas aeruginosa
ISSN:	0300-8126, 1439-0973, 1439-0973
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Shrnutí:	Introduction We describe the use of bacteriophage therapy in a 26-year-old cystic fibrosis (CF) patient awaiting lung transplantation. Hospital Course The patient developed multidrug resistant (MDR) Pseudomonas aeruginosa pneumonia, persistent respiratory failure, and colistin-induced renal failure. We describe the use of intravenous bacteriophage therapy (BT) along with systemic antibiotics in this patient, lack of adverse events, and clinical resolution of infection with this approach. She did not have recurrence of pseudomonal pneumonia and CF exacerbation within 100 days following the end of BT and underwent successful bilateral lung transplantation 9 months later. Conclusion Given the concern for MDR P. aeruginosa infections in CF patients, BT may offer a viable anti-infective adjunct to traditional antibiotic therapy.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Case Study-2 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0300-8126 1439-0973 1439-0973
DOI:	10.1007/s15010-019-01319-0