Role of Mitochondria in Ferroptosis

Ferroptosis is a regulated necrosis process driven by iron-dependent lipid peroxidation. Although ferroptosis and cellular metabolism interplay with one another, whether mitochondria are involved in ferroptosis is under debate. Here, we demonstrate that mitochondria play a crucial role in cysteine-d...

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Bibliographic Details
Published in:	Molecular cell Vol. 73; no. 2; p. 354
Main Authors:	Gao, Minghui, Yi, Junmei, Zhu, Jiajun, Minikes, Alexander M, Monian, Prashant, Thompson, Craig B, Jiang, Xuejun
Format:	Journal Article
Language:	English
Published:	United States 17.01.2019
Subjects:	Animals Cell Line, Tumor Citric Acid Cycle - drug effects Electron Transport Electron Transport Chain Complex Proteins - antagonists & inhibitors Electron Transport Chain Complex Proteins - metabolism Enzyme Inhibitors - pharmacology Fibroblasts - drug effects Fibroblasts - enzymology Fibroblasts - pathology Fumarate Hydratase - genetics Fumarate Hydratase - metabolism Glutamine - metabolism Glutathione Peroxidase - genetics Glutathione Peroxidase - metabolism Humans Iron - metabolism Lipid Peroxidation - drug effects Membrane Potential, Mitochondrial Mice Mitochondria - drug effects Mitochondria - enzymology Mitochondria - genetics Mitochondria - pathology Mutation Necrosis Phospholipid Hydroperoxide Glutathione Peroxidase Reactive Oxygen Species - metabolism Signal Transduction
ISSN:	1097-4164, 1097-4164
Online Access:	Get more information
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