Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis

The microbiome can promote or disrupt human health by influencing both adaptive and innate immune functions. We tested whether bacteria that normally reside on human skin participate in host defense by killing , a pathogen commonly found in patients with atopic dermatitis (AD) and an important facto...

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Veröffentlicht in:	Science translational medicine Jg. 9; H. 378
Hauptverfasser:	Nakatsuji, Teruaki, Chen, Tiffany H, Narala, Saisindhu, Chun, Kimberly A, Two, Aimee M, Yun, Tong, Shafiq, Faiza, Kotol, Paul F, Bouslimani, Amina, Melnik, Alexey V, Latif, Haythem, Kim, Ji-Nu, Lockhart, Alexandre, Artis, Keli, David, Gloria, Taylor, Patricia, Streib, Joanne, Dorrestein, Pieter C, Grier, Alex, Gill, Steven R, Zengler, Karsten, Hata, Tissa R, Leung, Donald Y M, Gallo, Richard L
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 22.02.2017
Schlagworte:	Amino Acid Sequence Animals Anti-Infective Agents - pharmacology Anti-Infective Agents - therapeutic use Antimicrobial Cationic Peptides - chemistry Antimicrobial Cationic Peptides - pharmacology Bacteria - drug effects Coagulase - metabolism Colony Count, Microbial Dermatitis, Atopic - drug therapy Dermatitis, Atopic - microbiology Dysbiosis - drug therapy Dysbiosis - microbiology Humans Mice Microbiota - drug effects Skin - microbiology Staphylococcus aureus - drug effects Staphylococcus aureus - growth & development Sus scrofa
ISSN:	1946-6242, 1946-6242
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