Sexually dimorphic RNA helicases DDX3X and DDX3Y differentially regulate RNA metabolism through phase separation

Sex differences are pervasive in human health and disease. One major key to sex-biased differences lies in the sex chromosomes. Although the functions of the X chromosome proteins are well appreciated, how they compare with their Y chromosome homologs remains elusive. Herein, using ensemble and sing...

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Veröffentlicht in:	Molecular cell Jg. 82; H. 14; S. 2588
Hauptverfasser:	Shen, Hui, Yanas, Amber, Owens, Michael C, Zhang, Celia, Fritsch, Clark, Fare, Charlotte M, Copley, Katie E, Shorter, James, Goldman, Yale E, Liu, Kathy Fange
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 21.07.2022
Schlagworte:	DEAD-box RNA Helicases - genetics DEAD-box RNA Helicases - metabolism Female Humans Male Minor Histocompatibility Antigens - metabolism Protein Biosynthesis Proteins - metabolism RNA - metabolism RNA Helicases - genetics RNA Helicases - metabolism DDX3Y translation repression DDX3X ATPase activity liquid-liquid phase separation condensates sex chromosome homolog proteins RNA helicase
ISSN:	1097-4164, 1097-4164
Online-Zugang:	Weitere Angaben
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