Glucagon-Like Peptide 1 and Its Analogs Act in the Dorsal Raphe and Modulate Central Serotonin to Reduce Appetite and Body Weight

Glucagon-like peptide 1 (GLP-1) and serotonin play critical roles in energy balance regulation. Both systems are exploited clinically as antiobesity strategies. Surprisingly, whether they interact in order to regulate energy balance is poorly understood. Here we investigated mechanisms by which GLP-...

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Bibliographic Details
Published in:	Diabetes (New York, N.Y.) Vol. 66; no. 4; pp. 1062 - 1073
Main Authors:	Anderberg, Rozita H, Richard, Jennifer E, Eerola, Kim, López-Ferreras, Lorena, Banke, Elin, Hansson, Caroline, Nissbrandt, Hans, Berqquist, Filip, Gribble, Fiona M, Reimann, Frank, Wernstedt Asterholm, Ingrid, Lamy, Christophe M, Skibicka, Karolina P
Format:	Journal Article
Language:	English
Published:	United States 01.04.2017
Subjects:	Aminopyridines - pharmacology Animals Anorexia Appetite - drug effects Body Weight - drug effects Dorsal Raphe Nucleus - metabolism Exenatide Feeding Behavior - drug effects Fenclonine - pharmacology Glucagon-Like Peptide 1 - pharmacology Glucagon-Like Peptide-1 Receptor - drug effects Glucagon-Like Peptide-1 Receptor - metabolism Hypoglycemic Agents - pharmacology Indoles - pharmacology Liraglutide - pharmacology Male Peptides - pharmacology Pyrrolidines - pharmacology Rats Rats, Sprague-Dawley Receptor, Serotonin, 5-HT2A - drug effects Receptor, Serotonin, 5-HT2A - metabolism Receptor, Serotonin, 5-HT2C - drug effects Receptor, Serotonin, 5-HT2C - metabolism Serotonin - metabolism Serotonin Antagonists - pharmacology Venoms - pharmacology Weight Loss - drug effects
ISSN:	1939-327X
Online Access:	Get more information
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