Diabetes and diabetes-associated lipid abnormalities have distinct effects on initiation and progression of atherosclerotic lesions

Diabetes in humans accelerates cardiovascular disease caused by atherosclerosis. The relative contributions of hyperglycemia and dyslipidemia to atherosclerosis in patients with diabetes are not clear, largely because there is a lack of suitable animal models. We therefore have developed a transgeni...

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Bibliographic Details
Published in:	The Journal of clinical investigation Vol. 114; no. 5; pp. 659 - 668
Main Authors:	Renard, Catherine B., Kramer, Farah, Johansson, Fredrik, Lamharzi, Najib, Tannock, Lisa R., Herrath, Matthias G. von, Chait, Alan, Bornfeldt, Karin E.
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 01.09.2004
Subjects:	Animals Arteriosclerosis - etiology Arteriosclerosis - metabolism Atherosclerosis Biomedical research Cholesterol Cholesterol, Dietary - administration & dosage Diabetes Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - metabolism Diet Glucose Glycated Hemoglobin A - metabolism Glycoproteins Hemoglobin Hyperglycemia Hyperglycemia - genetics Hyperglycemia - metabolism Insulin Islets of Langerhans - metabolism Islets of Langerhans - pathology Lipid Metabolism Lipids Low density lipoprotein receptors Metabolic disorders Mice Mice, Transgenic Receptors, LDL - deficiency Receptors, LDL - genetics
ISSN:	0021-9738, 1558-8238
Online Access:	Get full text
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