Metabolite-biomarker investigations in the life cycle of and infection with Schistosoma

Schistosome infection is endemic in many Third World countries and affects an estimated 200 million individuals. Over the last few years, a number of investigations have focused on small molecule biomarkers of this infection. These studies were aimed at discovering key molecules relating to the life...

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Vydáno v:Parasitology Ročník 137; číslo 9; s. 1425 - 1435
Hlavní autor: Legido-Quigley, C.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Cambridge, UK Cambridge University Press 01.08.2010
Témata:
Animals
Biomarkers - analysis
Biomarkers - urine
Humans
Life cycles
Liver - metabolism
Liver - parasitology
Metabolites
Metabolomics
metabonomics
Parasites
Schistosoma
Schistosoma - metabolism
Schistosome
Schistosomiasis - parasitology
Snails - metabolism
Snails - parasitology
metabonomics
metabolites
Schistosome
ISSN:0031-1820, 1469-8161, 1469-8161
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Shrnutí:Schistosome infection is endemic in many Third World countries and affects an estimated 200 million individuals. Over the last few years, a number of investigations have focused on small molecule biomarkers of this infection. These studies were aimed at discovering key molecules relating to the life cycle of the parasite or deciphering metabolic change in the host during infection. In this review these studies are further divided into targeted approaches to find compounds and fingerprinting techniques i.e. metabonomics. A species-specific metabolite or group of biomarkers of the infection have yet to be discovered. For this reason a critical discussion contrasting with established diagnostic methods and future prospects are also provided.
Bibliografie:istex:5F07267102A2BE8B7DB1F028695C490149B20AF9
ArticleID:00054
PII:S0031182010000545
ark:/67375/6GQ-NXF9BP84-1
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
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ISSN:0031-1820
1469-8161
1469-8161
DOI:10.1017/S0031182010000545