Metabolite-biomarker investigations in the life cycle of and infection with Schistosoma

Schistosome infection is endemic in many Third World countries and affects an estimated 200 million individuals. Over the last few years, a number of investigations have focused on small molecule biomarkers of this infection. These studies were aimed at discovering key molecules relating to the life...

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Vydáno v:	Parasitology Ročník 137; číslo 9; s. 1425 - 1435
Hlavní autor:	Legido-Quigley, C.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Cambridge, UK Cambridge University Press 01.08.2010
Témata:	Animals Biomarkers - analysis Biomarkers - urine Humans Life cycles Liver - metabolism Liver - parasitology Metabolites Metabolomics metabonomics Parasites Schistosoma Schistosoma - metabolism Schistosome Schistosomiasis - parasitology Snails - metabolism Snails - parasitology metabonomics metabolites Schistosome
ISSN:	0031-1820, 1469-8161, 1469-8161
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Abstract	Schistosome infection is endemic in many Third World countries and affects an estimated 200 million individuals. Over the last few years, a number of investigations have focused on small molecule biomarkers of this infection. These studies were aimed at discovering key molecules relating to the life cycle of the parasite or deciphering metabolic change in the host during infection. In this review these studies are further divided into targeted approaches to find compounds and fingerprinting techniques i.e. metabonomics. A species-specific metabolite or group of biomarkers of the infection have yet to be discovered. For this reason a critical discussion contrasting with established diagnostic methods and future prospects are also provided.
AbstractList	Schistosome infection is endemic in many Third World countries and affects an estimated 200 million individuals. Over the last few years, a number of investigations have focused on small molecule biomarkers of this infection. These studies were aimed at discovering key molecules relating to the life cycle of the parasite or deciphering metabolic change in the host during infection. In this review these studies are further divided into targeted approaches to find compounds and fingerprinting techniques i.e. metabonomics. A species-specific metabolite or group of biomarkers of the infection have yet to be discovered. For this reason a critical discussion contrasting with established diagnostic methods and future prospects are also provided. SUMMARY Schistosome infection is endemic in many Third World countries and affects an estimated 200 million individuals. Over the last few years, a number of investigations have focused on small molecule biomarkers of this infection. These studies were aimed at discovering key molecules relating to the life cycle of the parasite or deciphering metabolic change in the host during infection. In this review these studies are further divided into targeted approaches to find compounds and fingerprinting techniques i.e. metabonomics. A species-specific metabolite or group of biomarkers of the infection have yet to be discovered. For this reason a critical discussion contrasting with established diagnostic methods and future prospects are also provided. [PUBLICATION ABSTRACT] Schistosome infection is endemic in many Third World countries and affects an estimated 200 million individuals. Over the last few years, a number of investigations have focused on small molecule biomarkers of this infection. These studies were aimed at discovering key molecules relating to the life cycle of the parasite or deciphering metabolic change in the host during infection. In this review these studies are further divided into targeted approaches to find compounds and fingerprinting techniques i.e. metabonomics. A species-specific metabolite or group of biomarkers of the infection have yet to be discovered. For this reason a critical discussion contrasting with established diagnostic methods and future prospects are also provided.Schistosome infection is endemic in many Third World countries and affects an estimated 200 million individuals. Over the last few years, a number of investigations have focused on small molecule biomarkers of this infection. These studies were aimed at discovering key molecules relating to the life cycle of the parasite or deciphering metabolic change in the host during infection. In this review these studies are further divided into targeted approaches to find compounds and fingerprinting techniques i.e. metabonomics. A species-specific metabolite or group of biomarkers of the infection have yet to be discovered. For this reason a critical discussion contrasting with established diagnostic methods and future prospects are also provided.
Author	Legido-Quigley, C.
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CitedBy_id	crossref_primary_10_1186_s13071_015_0728_2 crossref_primary_10_3389_fmicb_2019_00440 crossref_primary_10_3389_fmicb_2014_00313 crossref_primary_10_1016_j_actatropica_2010_08_020 crossref_primary_10_1016_j_vetpar_2011_12_017 crossref_primary_10_1080_14789450_2021_2012454 crossref_primary_10_3389_fcimb_2021_781132 crossref_primary_10_1007_s12639_021_01395_w
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Snippet	Schistosome infection is endemic in many Third World countries and affects an estimated 200 million individuals. Over the last few years, a number of... SUMMARY Schistosome infection is endemic in many Third World countries and affects an estimated 200 million individuals. Over the last few years, a number of...
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SubjectTerms	Animals Biomarkers - analysis Biomarkers - urine Humans Life cycles Liver - metabolism Liver - parasitology Metabolites Metabolomics metabonomics Parasites Schistosoma Schistosoma - metabolism Schistosome Schistosomiasis - parasitology Snails - metabolism Snails - parasitology
Title	Metabolite-biomarker investigations in the life cycle of and infection with Schistosoma
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