Polysaccharide Composites with Rosa canina for Sustained Anti-Inflammatory Skin Therapy

This study presents novel skin-compatible biomaterials based on guar gum and dextran sulfate matrices, incorporating softwood lignin, lignin esterified with aspartic acid, and Rosa canina extract. The materials were prepared via casting and evaluated for physicochemical, mechanical, and biological p...

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Vydáno v:Polymers Ročník 17; číslo 12; s. 1707
Hlavní autoři: Anghel, Narcis, Apostol, Irina, Plaesu, Ioana, Mija, Alice, Simionescu, Natalia, Coroaba, Adina, Spiridon, Iuliana
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland MDPI AG 19.06.2025
MDPI
Témata:
Acids
Analysis
Antimicrobial agents
Aspartic acid
Biocompatibility
Biodegradable materials
Biological activity
Biological properties
Biomedical materials
Biopolymer denaturation
Biopolymers
Carbonyls
Care and treatment
Chemical processes
Chemical properties
Composite materials
Cosmetics
Dextrans
Elongation
Esterification
Guar gum
Hydration
Identification and classification
Lignin
Materia medica, Vegetable
Mechanical properties
Methods
Plant extracts
Polysaccharides
Roses
Skin
Solvents
Sustainability
Sustained release
Viscosity
France
Romania
United States > US
guar gum
dextran
skin applications
drug release
lignin aspartate
Rosa canina extract
ISSN:2073-4360, 2073-4360
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Shrnutí:This study presents novel skin-compatible biomaterials based on guar gum and dextran sulfate matrices, incorporating softwood lignin, lignin esterified with aspartic acid, and Rosa canina extract. The materials were prepared via casting and evaluated for physicochemical, mechanical, and biological properties. Spectroscopic analyses confirmed successful lignin esterification, with new carbonyl and amide peaks and a nitrogen signal (3.83%) detected. Rosa canina extract enhanced the Young’s modulus from 1.42 MPa to 3.18 MPa and reduced elongation at break from 34.88 mm to 25.19 mm. The combination of esterified lignin and Rosa canina showed the greatest mechanical reinforcement (3.74 MPa modulus, 23.78 mm elongation). Swelling capacity decreased from 0.40 to 0.23 g water/g material and followed pseudo-second-order kinetics (R2 = 0.991–0.998). The release of Rosa canina bioactives followed the Makoid–Banakar model, indicating a transition from rapid to sustained release. All formulations exhibited anti-inflammatory activity with over 45% protein denaturation inhibition, peaking at 61.58% for the Rosa canina-only sample. In vitro biocompatibility assays demonstrated over 80% cell viability, confirming the potential of these biomaterials for dermal applications.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:2073-4360
2073-4360
DOI:10.3390/polym17121707