High-Dose Intravenous Immunoglobulin as a Therapeutic Option for Deteriorating Patients With Coronavirus Disease 2019

Abstract The outbreak of coronavirus disease 2019 (COVID-19) has spread rapidly in China. Until now, no definite effective treatment has been identified. We reported on 3 patients with severe COVID-19 who received high-dose intravenous immunoglobulin (IVIg) with satisfactory recovery. Based on these...

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Veröffentlicht in:Open forum infectious diseases Jg. 7; H. 3; S. ofaa102
Hauptverfasser: Cao, Wei, Liu, Xiaosheng, Bai, Tao, Fan, Hongwei, Hong, Ke, Song, Hui, Han, Yang, Lin, Ling, Ruan, Lianguo, Li, Taisheng
Format: Journal Article
Sprache:Englisch
Veröffentlicht: US Oxford University Press 01.03.2020
Schlagworte:
Brief Report
immunomodulation
high-dose intravenous immunoglobulin
coronavirus disease 2019
ISSN:2328-8957, 2328-8957
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Abstract Abstract The outbreak of coronavirus disease 2019 (COVID-19) has spread rapidly in China. Until now, no definite effective treatment has been identified. We reported on 3 patients with severe COVID-19 who received high-dose intravenous immunoglobulin (IVIg) with satisfactory recovery. Based on these observations, randomized studies of high-dose IVIg should be considered in deteriorating patients infected with COVID-19.
AbstractList The outbreak of coronavirus disease 2019 (COVID-19) has spread rapidly in China. Until now, no definite effective treatment has been identified. We reported on 3 patients with severe COVID-19 who received high-dose intravenous immunoglobulin (IVIg) with satisfactory recovery. Based on these observations, randomized studies of high-dose IVIg should be considered in deteriorating patients infected with COVID-19.The outbreak of coronavirus disease 2019 (COVID-19) has spread rapidly in China. Until now, no definite effective treatment has been identified. We reported on 3 patients with severe COVID-19 who received high-dose intravenous immunoglobulin (IVIg) with satisfactory recovery. Based on these observations, randomized studies of high-dose IVIg should be considered in deteriorating patients infected with COVID-19.
The outbreak of coronavirus disease 2019 (COVID-19) has spread rapidly in China. Until now, no definite effective treatment has been identified. We reported on 3 patients with severe COVID-19 who received high-dose intravenous immunoglobulin (IVIg) with satisfactory recovery. Based on these observations, randomized studies of high-dose IVIg should be considered in deteriorating patients infected with COVID-19.
Abstract The outbreak of coronavirus disease 2019 (COVID-19) has spread rapidly in China. Until now, no definite effective treatment has been identified. We reported on 3 patients with severe COVID-19 who received high-dose intravenous immunoglobulin (IVIg) with satisfactory recovery. Based on these observations, randomized studies of high-dose IVIg should be considered in deteriorating patients infected with COVID-19.
Author Hong, Ke
Bai, Tao
Cao, Wei
Li, Taisheng
Han, Yang
Ruan, Lianguo
Song, Hui
Lin, Ling
Liu, Xiaosheng
Fan, Hongwei
AuthorAffiliation 2 Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University, Beijing, China
1 Department of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences , Beijing, China
3 Department of Infectious Diseases, Jin Yin-tan Hospital, Wuhan, China
AuthorAffiliation_xml – name: 3 Department of Infectious Diseases, Jin Yin-tan Hospital, Wuhan, China
– name: 1 Department of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences , Beijing, China
– name: 2 Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University, Beijing, China
Author_xml – sequence: 1
  givenname: Wei
  surname: Cao
  fullname: Cao, Wei
  organization: Department of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
– sequence: 2
  givenname: Xiaosheng
  surname: Liu
  fullname: Liu, Xiaosheng
  organization: Tsinghua-Peking Center for Life Sciences, School of Medicine, Tsinghua University, Beijing, China
– sequence: 3
  givenname: Tao
  surname: Bai
  fullname: Bai, Tao
  organization: Department of Infectious Diseases, Jin Yin-tan Hospital, Wuhan, China
– sequence: 4
  givenname: Hongwei
  surname: Fan
  fullname: Fan, Hongwei
  organization: Department of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
– sequence: 5
  givenname: Ke
  surname: Hong
  fullname: Hong, Ke
  organization: Department of Infectious Diseases, Jin Yin-tan Hospital, Wuhan, China
– sequence: 6
  givenname: Hui
  surname: Song
  fullname: Song, Hui
  organization: Department of Infectious Diseases, Jin Yin-tan Hospital, Wuhan, China
– sequence: 7
  givenname: Yang
  surname: Han
  fullname: Han, Yang
  organization: Department of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
– sequence: 8
  givenname: Ling
  surname: Lin
  fullname: Lin, Ling
  organization: Department of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
– sequence: 9
  givenname: Lianguo
  surname: Ruan
  fullname: Ruan, Lianguo
  organization: Department of Infectious Diseases, Jin Yin-tan Hospital, Wuhan, China
– sequence: 10
  givenname: Taisheng
  surname: Li
  fullname: Li, Taisheng
  email: litsh@263.net
  organization: Department of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32258207$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1016/S0140-6736(20)30183-5
10.1148/radiol.2020200230
10.3201/eid1005.030640
10.1007/s00415-008-3002-0
10.1056/NEJMoa2001017
10.1046/j.1365-2141.1999.01766.x
10.1002/art.38082
10.1212/WNL.0b013e31824de293
10.1086/525263
10.3928/19382359-20161213-03
10.7326/M13-2486
10.1093/intimm/dxx039
10.1016/S0140-6736(20)30251-8
ContentType Journal Article
Copyright The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. 2020
The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. 2020
– notice: The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
– notice: The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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Issue 3
Keywords immunomodulation
high-dose intravenous immunoglobulin
coronavirus disease 2019
Language English
License This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
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The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
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Lianguo Ruan and Taisheng Li Equal contribution
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References National Health Commission of the People’s Republic of China (2020040111350590400_CIT0002)
Hartung (2020040111350590400_CIT0013) 2008; 255
Wang (2020040111350590400_CIT0016) 2004; 10
Patwa (2020040111350590400_CIT0006) 2012; 78
Wan (2020040111350590400_CIT0009)
Gurwitz (2020040111350590400_CIT0010)
Huang (2020040111350590400_CIT0003) 2020; 395
Khanna (2020040111350590400_CIT0015) 2008; 46
Zhu (2020040111350590400_CIT0004) 2020; 382
Wiedeman (2020040111350590400_CIT0014) 2013; 65
Galeotti (2020040111350590400_CIT0011) 2017; 29
De Ranieri (2020040111350590400_CIT0012) 2017; 46
2020040111350590400_CIT0001
Godeau (2020040111350590400_CIT0007) 1999; 107
Lu (2020040111350590400_CIT0008) 2020; 395
Arabi (2020040111350590400_CIT0017) 2014; 160
Chung (2020040111350590400_CIT0005) 2020; 295
References_xml – volume: 395
  start-page: 497
  year: 2020
  ident: 2020040111350590400_CIT0003
  article-title: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
  publication-title: Lancet
  doi: 10.1016/S0140-6736(20)30183-5
– volume: 295
  start-page: 202
  year: 2020
  ident: 2020040111350590400_CIT0005
  article-title: CT imaging features of 2019 novel coronavirus (2019-nCoV)
  publication-title: Radiology
  doi: 10.1148/radiol.2020200230
– volume: 10
  start-page: 818
  year: 2004
  ident: 2020040111350590400_CIT0016
  article-title: Clinical manifestations, laboratory findings, and treatment outcomes of SARS patients
  publication-title: Emerg Infect Dis
  doi: 10.3201/eid1005.030640
– volume: 255
  start-page: 3
  year: 2008
  ident: 2020040111350590400_CIT0013
  article-title: Advances in the understanding of the mechanism of action of IVIg
  publication-title: J Neurol
  doi: 10.1007/s00415-008-3002-0
– volume: 382
  start-page: 727
  year: 2020
  ident: 2020040111350590400_CIT0004
  article-title: A novel coronavirus from patients with pneumonia in China, 2019
  publication-title: New Engl J Med
  doi: 10.1056/NEJMoa2001017
– volume: 107
  start-page: 716
  year: 1999
  ident: 2020040111350590400_CIT0007
  article-title: Intravenous immunoglobulin for adults with autoimmune thrombocytopenic purpura: results of a randomized trial comparing 0.5 and 1 g/kg b.w
  publication-title: Br J Haematol
  doi: 10.1046/j.1365-2141.1999.01766.x
– ident: 2020040111350590400_CIT0001
– volume: 65
  start-page: 2713
  year: 2013
  ident: 2020040111350590400_CIT0014
  article-title: Contrasting mechanisms of interferon-α inhibition by intravenous immunoglobulin after induction by immune complexes versus Toll-like receptor agonists
  publication-title: Arthritis Rheum
  doi: 10.1002/art.38082
– volume: 78
  start-page: 1009
  year: 2012
  ident: 2020040111350590400_CIT0006
  article-title: Evidence-based guideline: intravenous immunoglobulin in the treatment of neuromuscular disorders: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology
  publication-title: Neurology
  doi: 10.1212/WNL.0b013e31824de293
– volume: 46
  start-page: 402
  year: 2008
  ident: 2020040111350590400_CIT0015
  article-title: Respiratory syncytial virus infection in patients with hematological diseases: single-center study and review of the literature
  publication-title: Clin Infect Dis
  doi: 10.1086/525263
– volume: 46
  start-page: e8
  year: 2017
  ident: 2020040111350590400_CIT0012
  article-title: Intravenous immunoglobulin in the treatment of primary immunodeficiency diseases
  publication-title: Pediatr Ann
  doi: 10.3928/19382359-20161213-03
– volume: 160
  start-page: 389
  year: 2014
  ident: 2020040111350590400_CIT0017
  article-title: Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection
  publication-title: Ann Intern Med
  doi: 10.7326/M13-2486
– ident: 2020040111350590400_CIT0009
  article-title: Receptor recognition by novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS
  publication-title: J Virol
– ident: 2020040111350590400_CIT0010
  article-title: Angiotensin receptor blockers as tentative SARS-CoV-2 therapeutics
  publication-title: Drug Dev Res
– ident: 2020040111350590400_CIT0002
– volume: 29
  start-page: 491
  year: 2017
  ident: 2020040111350590400_CIT0011
  article-title: IVIG-mediated effector functions in autoimmune and inflammatory diseases
  publication-title: Int Immunol
  doi: 10.1093/intimm/dxx039
– volume: 395
  start-page: 565
  year: 2020
  ident: 2020040111350590400_CIT0008
  article-title: Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding
  publication-title: Lancet
  doi: 10.1016/S0140-6736(20)30251-8
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Snippet Abstract The outbreak of coronavirus disease 2019 (COVID-19) has spread rapidly in China. Until now, no definite effective treatment has been identified. We...
The outbreak of coronavirus disease 2019 (COVID-19) has spread rapidly in China. Until now, no definite effective treatment has been identified. We reported on...
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Title High-Dose Intravenous Immunoglobulin as a Therapeutic Option for Deteriorating Patients With Coronavirus Disease 2019
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