A 24-step guide on how to design, conduct, and successfully publish a systematic review and meta-analysis in medical research

To inform evidence-based practice in health care, guidelines and policies require accurate identification, collation, and integration of all available evidence in a comprehensive, meaningful, and time-efficient manner. Approaches to evidence synthesis such as carefully conducted systematic reviews a...

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Veröffentlicht in:European journal of epidemiology Jg. 35; H. 1; S. 49 - 60
Hauptverfasser: Muka, Taulant, Glisic, Marija, Milic, Jelena, Verhoog, Sanne, Bohlius, Julia, Bramer, Wichor, Chowdhury, Rajiv, Franco, Oscar H.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Dordrecht Springer Netherlands 01.01.2020
Springer Nature B.V
Schlagworte:
Cardiology
Clinical trials
Complexity
Epidemiology
Guidelines
Guidelines as Topic
Health care
Humans
Infectious Diseases
Literature reviews
Medical electronics
Medical research
Medicine
Medicine & Public Health
Meta-analysis
Meta-Analysis as Topic
Observational studies
Oncology
Public Health
Synthesis
Systematic review
Systematic Reviews as Topic
24 Steps
Systematic review
Guideline
Evidence synthesis
Meta-analysis
ISSN:0393-2990, 1573-7284, 1573-7284
Online-Zugang:Volltext
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Zusammenfassung:To inform evidence-based practice in health care, guidelines and policies require accurate identification, collation, and integration of all available evidence in a comprehensive, meaningful, and time-efficient manner. Approaches to evidence synthesis such as carefully conducted systematic reviews and meta-analyses are essential tools to summarize specific topics. Unfortunately, not all systematic reviews are truly systematic, and their quality can vary substantially. Since well-conducted evidence synthesis typically involves a complex set of steps, we believe formulating a cohesive, step-by-step guide on how to conduct a systemic review and meta-analysis is essential. While most of the guidelines on systematic reviews focus on how to report or appraise systematic reviews, they lack guidance on how to synthesize evidence efficiently. To facilitate the design and development of evidence syntheses, we provide a clear and concise, 24-step guide on how to perform a systematic review and meta-analysis of observational studies and clinical trials. We describe each step, illustrate it with concrete examples, and provide relevant references for further guidance. The 24-step guide (1) simplifies the methodology of conducting a systematic review, (2) provides healthcare professionals and researchers with methodologically sound tools for conducting systematic reviews and meta-analyses, and (3) it can enhance the quality of existing evidence synthesis efforts. This guide will help its readers to better understand the complexity of the process, appraise the quality of published systematic reviews, and better comprehend (and use) evidence from medical literature.
Bibliographie:ObjectType-Article-2
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ObjectType-Evidence Based Healthcare-1
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ISSN:0393-2990
1573-7284
1573-7284
DOI:10.1007/s10654-019-00576-5