A TICT based NIR-fluorescent probe for human serum albumin: a pre-clinical diagnosis in blood serum

A TICT based NIR-fluorescent probe 3 has been designed and synthesized, which selectively detects HSA with fluorescence enhancement in blood plasma with a detection limit of 11 nM among the various proteins, nucleotides and thiols tested.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) Vol. 52; no. 6; pp. 1182 - 1185
Main Authors: Reja, Shahi Imam, Khan, Imran A., Bhalla, Vandana, Kumar, Manoj
Format: Journal Article
Language:English
Published: CAMBRIDGE Royal Soc Chemistry 01.01.2016
Subjects:
Chemistry
Chemistry, Multidisciplinary
Crystallography, X-Ray
Diagnosis
Fluorescent Dyes - chemistry
Humans
Limit of Detection
Physical Sciences
Science & Technology
Serum Albumin - analysis
Spectroscopy, Near-Infrared - methods
SQUARAINE
ACTIVATION
CHARGE-TRANSFER
BINDING
ISSN:1359-7345, 1364-548X
Online Access:Get more information
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Description
Summary:A TICT based NIR-fluorescent probe 3 has been designed and synthesized, which selectively detects HSA with fluorescence enhancement in blood plasma with a detection limit of 11 nM among the various proteins, nucleotides and thiols tested.
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ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc08217j