The role of thioredoxin system in cancer: strategy for cancer therapy

Purpose Cancer, a major public health problem, exhibits significant redox alteration. Thioredoxin (Trx) system, including Trx and Trx reductase (TrxR), as well as Trx-interacting protein (TXNIP) play important roles in controlling the cellular redox balance in cancer cells. In most cancers, Trx and...

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Bibliographic Details
Published in:	Cancer chemotherapy and pharmacology Vol. 84; no. 3; pp. 453 - 470
Main Authors:	Jia, Jin-Jing, Geng, Wen-Shuo, Wang, Zhan-Qi, Chen, Lei, Zeng, Xian-Si
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2019 Springer Nature B.V
Subjects:	Antineoplastic Agents - therapeutic use Antitumor activity Cancer Cancer Research Cancer therapies Cytotoxicity Humans Medicine Medicine & Public Health Molecular Targeted Therapy Neoplasms - drug therapy Neoplasms - metabolism Oncology Pharmacology/Toxicology Public health Reductase Review Article Thioredoxin Thioredoxins - antagonists & inhibitors Redox Inhibitor Thioredoxin system Combined therapy Cancer
ISSN:	0344-5704, 1432-0843, 1432-0843
Online Access:	Get full text
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