The role of thioredoxin system in cancer: strategy for cancer therapy

Purpose Cancer, a major public health problem, exhibits significant redox alteration. Thioredoxin (Trx) system, including Trx and Trx reductase (TrxR), as well as Trx-interacting protein (TXNIP) play important roles in controlling the cellular redox balance in cancer cells. In most cancers, Trx and...

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Published in:Cancer chemotherapy and pharmacology Vol. 84; no. 3; pp. 453 - 470
Main Authors: Jia, Jin-Jing, Geng, Wen-Shuo, Wang, Zhan-Qi, Chen, Lei, Zeng, Xian-Si
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2019
Springer Nature B.V
Subjects:
Antineoplastic Agents - therapeutic use
Antitumor activity
Cancer
Cancer Research
Cancer therapies
Cytotoxicity
Humans
Medicine
Medicine & Public Health
Molecular Targeted Therapy
Neoplasms - drug therapy
Neoplasms - metabolism
Oncology
Pharmacology/Toxicology
Public health
Reductase
Review Article
Thioredoxin
Thioredoxins - antagonists & inhibitors
Redox
Inhibitor
Thioredoxin system
Combined therapy
Cancer
ISSN:0344-5704, 1432-0843, 1432-0843
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Abstract Purpose Cancer, a major public health problem, exhibits significant redox alteration. Thioredoxin (Trx) system, including Trx and Trx reductase (TrxR), as well as Trx-interacting protein (TXNIP) play important roles in controlling the cellular redox balance in cancer cells. In most cancers, Trx and TrxR are usually overexpressed and TXNIP is underexpressed. In recent years, some agents targeting Trx, TrxR, and TXNIP were used to explore a therapy approach for cancer patients. Methods A systematic search of PMC and the PubMed Database was conducted to summarize the potential of Trx system inhibitors for cancer treatment. Results In this article, we first summarize the functions of Trx, TrxR, and TXNIP in cancers. We also review some small molecule inhibitors of Trx/TrxR and d -allose (TXNIP inducer) and discuss their antitumor mechanisms. We highlight the combined inhibition of Trx system and GSH system in cancer therapy. We expect that a highly specific and selective antitumor agent with no cytotoxicity on human normal cells could be developed in the future. Conclusion In conclusion, Trx system may be very promising for clinical therapy of cancer in the future.
AbstractList Purpose Cancer, a major public health problem, exhibits significant redox alteration. Thioredoxin (Trx) system, including Trx and Trx reductase (TrxR), as well as Trx-interacting protein (TXNIP) play important roles in controlling the cellular redox balance in cancer cells. In most cancers, Trx and TrxR are usually overexpressed and TXNIP is underexpressed. In recent years, some agents targeting Trx, TrxR, and TXNIP were used to explore a therapy approach for cancer patients. Methods A systematic search of PMC and the PubMed Database was conducted to summarize the potential of Trx system inhibitors for cancer treatment. Results In this article, we first summarize the functions of Trx, TrxR, and TXNIP in cancers. We also review some small molecule inhibitors of Trx/TrxR and d -allose (TXNIP inducer) and discuss their antitumor mechanisms. We highlight the combined inhibition of Trx system and GSH system in cancer therapy. We expect that a highly specific and selective antitumor agent with no cytotoxicity on human normal cells could be developed in the future. Conclusion In conclusion, Trx system may be very promising for clinical therapy of cancer in the future.
PurposeCancer, a major public health problem, exhibits significant redox alteration. Thioredoxin (Trx) system, including Trx and Trx reductase (TrxR), as well as Trx-interacting protein (TXNIP) play important roles in controlling the cellular redox balance in cancer cells. In most cancers, Trx and TrxR are usually overexpressed and TXNIP is underexpressed. In recent years, some agents targeting Trx, TrxR, and TXNIP were used to explore a therapy approach for cancer patients.MethodsA systematic search of PMC and the PubMed Database was conducted to summarize the potential of Trx system inhibitors for cancer treatment.ResultsIn this article, we first summarize the functions of Trx, TrxR, and TXNIP in cancers. We also review some small molecule inhibitors of Trx/TrxR and d-allose (TXNIP inducer) and discuss their antitumor mechanisms. We highlight the combined inhibition of Trx system and GSH system in cancer therapy. We expect that a highly specific and selective antitumor agent with no cytotoxicity on human normal cells could be developed in the future.ConclusionIn conclusion, Trx system may be very promising for clinical therapy of cancer in the future.
Cancer, a major public health problem, exhibits significant redox alteration. Thioredoxin (Trx) system, including Trx and Trx reductase (TrxR), as well as Trx-interacting protein (TXNIP) play important roles in controlling the cellular redox balance in cancer cells. In most cancers, Trx and TrxR are usually overexpressed and TXNIP is underexpressed. In recent years, some agents targeting Trx, TrxR, and TXNIP were used to explore a therapy approach for cancer patients.PURPOSECancer, a major public health problem, exhibits significant redox alteration. Thioredoxin (Trx) system, including Trx and Trx reductase (TrxR), as well as Trx-interacting protein (TXNIP) play important roles in controlling the cellular redox balance in cancer cells. In most cancers, Trx and TrxR are usually overexpressed and TXNIP is underexpressed. In recent years, some agents targeting Trx, TrxR, and TXNIP were used to explore a therapy approach for cancer patients.A systematic search of PMC and the PubMed Database was conducted to summarize the potential of Trx system inhibitors for cancer treatment.METHODSA systematic search of PMC and the PubMed Database was conducted to summarize the potential of Trx system inhibitors for cancer treatment.In this article, we first summarize the functions of Trx, TrxR, and TXNIP in cancers. We also review some small molecule inhibitors of Trx/TrxR and D-allose (TXNIP inducer) and discuss their antitumor mechanisms. We highlight the combined inhibition of Trx system and GSH system in cancer therapy. We expect that a highly specific and selective antitumor agent with no cytotoxicity on human normal cells could be developed in the future.RESULTSIn this article, we first summarize the functions of Trx, TrxR, and TXNIP in cancers. We also review some small molecule inhibitors of Trx/TrxR and D-allose (TXNIP inducer) and discuss their antitumor mechanisms. We highlight the combined inhibition of Trx system and GSH system in cancer therapy. We expect that a highly specific and selective antitumor agent with no cytotoxicity on human normal cells could be developed in the future.In conclusion, Trx system may be very promising for clinical therapy of cancer in the future.CONCLUSIONIn conclusion, Trx system may be very promising for clinical therapy of cancer in the future.
Cancer, a major public health problem, exhibits significant redox alteration. Thioredoxin (Trx) system, including Trx and Trx reductase (TrxR), as well as Trx-interacting protein (TXNIP) play important roles in controlling the cellular redox balance in cancer cells. In most cancers, Trx and TrxR are usually overexpressed and TXNIP is underexpressed. In recent years, some agents targeting Trx, TrxR, and TXNIP were used to explore a therapy approach for cancer patients. A systematic search of PMC and the PubMed Database was conducted to summarize the potential of Trx system inhibitors for cancer treatment. In this article, we first summarize the functions of Trx, TrxR, and TXNIP in cancers. We also review some small molecule inhibitors of Trx/TrxR and D-allose (TXNIP inducer) and discuss their antitumor mechanisms. We highlight the combined inhibition of Trx system and GSH system in cancer therapy. We expect that a highly specific and selective antitumor agent with no cytotoxicity on human normal cells could be developed in the future. In conclusion, Trx system may be very promising for clinical therapy of cancer in the future.
Author Wang, Zhan-Qi
Geng, Wen-Shuo
Jia, Jin-Jing
Zeng, Xian-Si
Chen, Lei
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  fullname: Wang, Zhan-Qi
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  givenname: Lei
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  fullname: Chen, Lei
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  givenname: Xian-Si
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  organization: Key Laboratory of Tea Plant Biology of Henan Province, College of Life Sciences, Xinyang Normal University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31079220$$D View this record in MEDLINE/PubMed
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Cancer Chemotherapy and Pharmacology is a copyright of Springer, (2019). All Rights Reserved.
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ISSN 0344-5704
1432-0843
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Sat Nov 29 04:45:34 EST 2025
Tue Nov 18 20:45:15 EST 2025
Fri Feb 21 02:33:15 EST 2025
IsPeerReviewed true
IsScholarly true
Issue 3
Keywords Redox
Inhibitor
Thioredoxin system
Combined therapy
Cancer
Language English
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PublicationCentury 2000
PublicationDate 2019-09-01
PublicationDateYYYYMMDD 2019-09-01
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  year: 2019
  text: 2019-09-01
  day: 01
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PublicationPlace Berlin/Heidelberg
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PublicationTitle Cancer chemotherapy and pharmacology
PublicationTitleAbbrev Cancer Chemother Pharmacol
PublicationTitleAlternate Cancer Chemother Pharmacol
PublicationYear 2019
Publisher Springer Berlin Heidelberg
Springer Nature B.V
Publisher_xml – name: Springer Berlin Heidelberg
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Snippet Purpose Cancer, a major public health problem, exhibits significant redox alteration. Thioredoxin (Trx) system, including Trx and Trx reductase (TrxR), as well...
Cancer, a major public health problem, exhibits significant redox alteration. Thioredoxin (Trx) system, including Trx and Trx reductase (TrxR), as well as...
PurposeCancer, a major public health problem, exhibits significant redox alteration. Thioredoxin (Trx) system, including Trx and Trx reductase (TrxR), as well...
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SubjectTerms Antineoplastic Agents - therapeutic use
Antitumor activity
Cancer
Cancer Research
Cancer therapies
Cytotoxicity
Humans
Medicine
Medicine & Public Health
Molecular Targeted Therapy
Neoplasms - drug therapy
Neoplasms - metabolism
Oncology
Pharmacology/Toxicology
Public health
Reductase
Review Article
Thioredoxin
Thioredoxins - antagonists & inhibitors
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Title The role of thioredoxin system in cancer: strategy for cancer therapy
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