Distinct T cell signatures are associated with Staphylococcus aureus skin infection in pediatric atopic dermatitis

Atopic dermatitis (AD) is an inflammatory skin condition with a childhood prevalence of up to 25%. Microbial dysbiosis is characteristic of AD, with Staphylococcus aureus the most frequent pathogen associated with disease flares and increasingly implicated in disease pathogenesis. Therapeutics to mi...

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Bibliographic Details
Published in:	JCI insight Vol. 9; no. 9
Main Authors:	Clowry, Julianne, Dempsey, Daniel J., Claxton, Tracey J., Towell, Aisling M., Turley, Mary B., Sutton, Martin, Geoghegan, Joan A., Kezic, Sanja, Jakasa, Ivone, White, Arthur, Irvine, Alan D., McLoughlin, Rachel M.
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 08.05.2024 American Society for Clinical investigation
Subjects:	Antibiotics Antigens Antigens, Differentiation, T-Lymphocyte Atopic dermatitis Bayes Theorem Bayesian analysis CD4 antigen CD8 antigen CD8-Positive T-Lymphocytes - immunology Chemokine CXCL10 - immunology Chemokine CXCL10 - metabolism Chemokines Child Child, Preschool Children Dermatitis Dermatitis, Atopic - immunology Dermatitis, Atopic - microbiology Dermatology Disease Dysbacteriosis Female Helper cells Humans Immune response Immunity (Disease) Immunological memory Immunology Interleukin-10 - immunology Interleukin-10 - metabolism Intraepithelial Lymphocytes - immunology Lymphocytes Lymphocytes T Male Membrane Glycoproteins Memory cells Pathogenesis Pathogens Patients Pediatrics Skin - immunology Skin - microbiology Skin - pathology Skin diseases Staphylococcal Skin Infections - immunology Staphylococcal Skin Infections - microbiology Staphylococcus aureus Staphylococcus aureus - immunology Staphylococcus infections Th1 Cells - immunology Th17 Cells - immunology Th2 Cells - immunology Vaccines Dermatology Adaptive immunity Immunology
ISSN:	2379-3708, 2379-3708
Online Access:	Get full text
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