The chemical biology of ubiquitin

This mini-review will cover the various chemical biology approaches employed to prepare and modulate ubiquitin chains and the ubiquitin-proteasome system. Emphasis will be given to the biochemistry and chemical biology of poly-ubiquitin chain preparation as a tool to elucidate its roles in biologica...

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Vydáno v:Biochimica et biophysica acta. General subjects Ročník 1866; číslo 3; s. 130079
Hlavní autor: Burslem, George M.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Netherlands Elsevier B.V 01.03.2022
Témata:
Animals
Chemical biology
Humans
Polyubiquitin - chemistry
Polyubiquitin - metabolism
proteasome endopeptidase complex
Proteasome Endopeptidase Complex - chemistry
Proteasome Endopeptidase Complex - metabolism
Protein synthesis
Ubiquitin
Ubiquitin - metabolism
Ubiquitination
Chemical biology
Ubiquitin
Protein synthesis
ISSN:0304-4165, 1872-8006, 1872-8006
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Shrnutí:This mini-review will cover the various chemical biology approaches employed to prepare and modulate ubiquitin chains and the ubiquitin-proteasome system. Emphasis will be given to the biochemistry and chemical biology of poly-ubiquitin chain preparation as a tool to elucidate its roles in biological systems as well as the hijacking of the ubiquitin proteasome system using heterobifunctional compounds to induce intracellular ubiquitination. •Ubiquitination is a diverse and critical to understand post-translational modification.•Chemical biology approaches provide unique opportunities to prepare and study polyubiquitin chains.•Novel tools are emerging for the control of ubiquitination inside mammalian cells.
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ISSN:0304-4165
1872-8006
1872-8006
DOI:10.1016/j.bbagen.2021.130079