The chemical biology of ubiquitin

This mini-review will cover the various chemical biology approaches employed to prepare and modulate ubiquitin chains and the ubiquitin-proteasome system. Emphasis will be given to the biochemistry and chemical biology of poly-ubiquitin chain preparation as a tool to elucidate its roles in biologica...

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Veröffentlicht in:Biochimica et biophysica acta. General subjects Jg. 1866; H. 3; S. 130079
1. Verfasser: Burslem, George M.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Netherlands Elsevier B.V 01.03.2022
Schlagworte:
Animals
Chemical biology
Humans
Polyubiquitin - chemistry
Polyubiquitin - metabolism
proteasome endopeptidase complex
Proteasome Endopeptidase Complex - chemistry
Proteasome Endopeptidase Complex - metabolism
Protein synthesis
Ubiquitin
Ubiquitin - metabolism
Ubiquitination
Chemical biology
Ubiquitin
Protein synthesis
ISSN:0304-4165, 1872-8006, 1872-8006
Online-Zugang:Volltext
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Beschreibung
Zusammenfassung:This mini-review will cover the various chemical biology approaches employed to prepare and modulate ubiquitin chains and the ubiquitin-proteasome system. Emphasis will be given to the biochemistry and chemical biology of poly-ubiquitin chain preparation as a tool to elucidate its roles in biological systems as well as the hijacking of the ubiquitin proteasome system using heterobifunctional compounds to induce intracellular ubiquitination. •Ubiquitination is a diverse and critical to understand post-translational modification.•Chemical biology approaches provide unique opportunities to prepare and study polyubiquitin chains.•Novel tools are emerging for the control of ubiquitination inside mammalian cells.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
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ISSN:0304-4165
1872-8006
1872-8006
DOI:10.1016/j.bbagen.2021.130079