Tumor-associated macrophages: role in cancer development and therapeutic implications

Background Tumor-associated macrophages (TAMs) are known to play important roles in the initiation and progression of human cancers, as well as in angiogenesis. TAMs are considered as main components of the tumor microenvironment. Targeting TAMs may serve as a therapeutic strategy for the treatment...

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Vydáno v:	Cellular oncology (Dordrecht) Ročník 42; číslo 5; s. 591 - 608
Hlavní autoři:	Salmaninejad, Arash, Valilou, Saeed Farajzadeh, Soltani, Arash, Ahmadi, Sepideh, Abarghan, Yousef Jafari, Rosengren, Rhonda J., Sahebkar, Amirhossein
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Dordrecht Springer Netherlands 01.10.2019 Springer Nature B.V
Témata:	Angiogenesis Biomedical and Life Sciences Biomedicine Cancer Cancer Research Cell Transformation, Neoplastic - metabolism Disease Progression Extravasation Humans Inflammation - immunology Inflammation - metabolism Macrophages Macrophages - immunology Macrophages - metabolism Metastases Metastasis Neoplasm Metastasis - drug therapy Neoplasm Metastasis - immunology Neoplasms - blood supply Neoplasms - immunology Neoplasms - metabolism Neoplasms - pathology Neovascularization, Pathologic - immunology Neovascularization, Pathologic - metabolism Oncology Pathology Review Signal Transduction - genetics Signal Transduction - immunology Tumor Microenvironment - immunology TAM Angiogenesis Targeted therapy Immunotherapy Metastasis Macrophage Cancer
ISSN:	2211-3428, 2211-3436, 2211-3436
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Shrnutí:	Background Tumor-associated macrophages (TAMs) are known to play important roles in the initiation and progression of human cancers, as well as in angiogenesis. TAMs are considered as main components of the tumor microenvironment. Targeting TAMs may serve as a therapeutic strategy for the treatment of cancer. In this review, the signaling pathways, origin, function, polarization and clinical application of TAMs are discussed. The role of TAMs in tumor initiation, progression, angiogenesis, invasion and metastasis are also emphasized. In addition, a variety of clinical and pre-clinical approaches to target TAMs are discussed. Conclusions Clinical therapeutic approaches that show most promise include blocking the extravasation of TAMs along with using TAMs as diagnostic biomarkers for cancer progression. The targeting of TAMs in a variety of clinical settings appears to be a promising strategy for decreasing metastasis formation and for improving patient outcome.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	2211-3428 2211-3436 2211-3436
DOI:	10.1007/s13402-019-00453-z