Tumor-associated macrophages: role in cancer development and therapeutic implications

Background Tumor-associated macrophages (TAMs) are known to play important roles in the initiation and progression of human cancers, as well as in angiogenesis. TAMs are considered as main components of the tumor microenvironment. Targeting TAMs may serve as a therapeutic strategy for the treatment...

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Published in:Cellular oncology (Dordrecht) Vol. 42; no. 5; pp. 591 - 608
Main Authors: Salmaninejad, Arash, Valilou, Saeed Farajzadeh, Soltani, Arash, Ahmadi, Sepideh, Abarghan, Yousef Jafari, Rosengren, Rhonda J., Sahebkar, Amirhossein
Format: Journal Article
Language:English
Published: Dordrecht Springer Netherlands 01.10.2019
Springer Nature B.V
Subjects:
Angiogenesis
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer Research
Cell Transformation, Neoplastic - metabolism
Disease Progression
Extravasation
Humans
Inflammation - immunology
Inflammation - metabolism
Macrophages
Macrophages - immunology
Macrophages - metabolism
Metastases
Metastasis
Neoplasm Metastasis - drug therapy
Neoplasm Metastasis - immunology
Neoplasms - blood supply
Neoplasms - immunology
Neoplasms - metabolism
Neoplasms - pathology
Neovascularization, Pathologic - immunology
Neovascularization, Pathologic - metabolism
Oncology
Pathology
Review
Signal Transduction - genetics
Signal Transduction - immunology
Tumor Microenvironment - immunology
TAM
Angiogenesis
Targeted therapy
Immunotherapy
Metastasis
Macrophage
Cancer
ISSN:2211-3428, 2211-3436, 2211-3436
Online Access:Get full text
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Summary:Background Tumor-associated macrophages (TAMs) are known to play important roles in the initiation and progression of human cancers, as well as in angiogenesis. TAMs are considered as main components of the tumor microenvironment. Targeting TAMs may serve as a therapeutic strategy for the treatment of cancer. In this review, the signaling pathways, origin, function, polarization and clinical application of TAMs are discussed. The role of TAMs in tumor initiation, progression, angiogenesis, invasion and metastasis are also emphasized. In addition, a variety of clinical and pre-clinical approaches to target TAMs are discussed. Conclusions Clinical therapeutic approaches that show most promise include blocking the extravasation of TAMs along with using TAMs as diagnostic biomarkers for cancer progression. The targeting of TAMs in a variety of clinical settings appears to be a promising strategy for decreasing metastasis formation and for improving patient outcome.
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ISSN:2211-3428
2211-3436
2211-3436
DOI:10.1007/s13402-019-00453-z