Evaluating multiple sclerosis severity loci 30 years after a clinically isolated syndrome

Abstract The first genome-wide significant multiple sclerosis severity locus, rs10191329, has been pathologically linked to cortical lesion load and brain atrophy. However, observational cohorts such as MSBase have not replicated associations with disability outcomes, instead finding other loci. We...

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Veröffentlicht in:	Brain communications Jg. 6; H. 6; S. fcae443
Hauptverfasser:	Sahi, Nitin, Haider, Lukas, Chung, Karen, Prados Carrasco, Ferran, Kanber, Baris, Samson, Rebecca, Thompson, Alan J, Trip, S Anand, Brownlee, Wallace, Ciccarelli, Olga, Barkhof, Frederik, Tur, Carmen, Houlden, Henry, Chard, Declan
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	UK Oxford University Press 2024
Schlagworte:	severity phenotype genetics disease progression multiple sclerosis
ISSN:	2632-1297, 2632-1297
Online-Zugang:	Volltext
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