Anatomically distinct fibroblast subsets determine skin autoimmune patterns

The skin serves as a physical barrier and an immunological interface that protects the body from the external environment 1 – 3 . Aberrant activation of immune cells can induce common skin autoimmune diseases such as vitiligo, which are often characterized by bilateral symmetric lesions in certain a...

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Veröffentlicht in:	Nature (London) Jg. 601; H. 7891; S. 118 - 124
Hauptverfasser:	Xu, Zijian, Chen, Daoming, Hu, Yucheng, Jiang, Kaiju, Huang, Huanwei, Du, Yingxue, Wu, Wenbo, Wang, Jiawen, Sui, Jianhua, Wang, Wenhui, Zhang, Long, Li, Shuli, Li, Chunying, Yang, Yong, Chang, Jianmin, Chen, Ting
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 06.01.2022 Nature Publishing Group
Schlagworte:	13/31 13/89 14/19 38/91 631/136/756 631/250/38 64/60 Adolescent Adult Animal models Animals Antigens Autoimmune diseases Autoimmune Diseases - immunology Autoimmune Diseases - pathology Barriers CD8 antigen CD8-Positive T-Lymphocytes - immunology Cell activation Chemokine CXCL10 - immunology Chemokine CXCL9 - immunology Chemokines Child Cytotoxicity Disease Models, Animal Experiments Female Fibroblasts Fibroblasts - immunology Fibroblasts - pathology Humanities and Social Sciences Humans Immune system Immunology Interferon Interferon-gamma - immunology Lesions Lymphocytes Lymphocytes T Male Melanocytes Melanocytes - immunology Melanocytes - pathology Melanoma Mesenchyme Mice Middle Aged multidisciplinary Paracrine Communication Patients RNA-Seq Science Science (multidisciplinary) Single-Cell Analysis Skin Skin - immunology Skin - pathology Skin diseases Stromal Cells - immunology Subpopulations T-Lymphocytes, Cytotoxic - immunology Therapeutic targets Vitiligo Vitiligo - immunology Vitiligo - pathology Young Adult γ-Interferon
ISSN:	0028-0836, 1476-4687, 1476-4687
Online-Zugang:	Volltext
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