The roles of intrinsically disordered proteins in neurodegeneration

Neurodegenerative diseases such as Amyotrophic Lateral Sclerosis, Alzheimer's disease, Parkinson's disease, and Huntington's disease share a common pathological hallmark: the accumulation of misfolded proteins, particularly involving intrinsically disordered proteins (IDPs) like TDP-4...

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Vydáno v:	Biochimica et biophysica acta. General subjects Ročník 1869; číslo 4; s. 130772
Hlavní autoři:	Utami, Kagistia Hana, Morimoto, Satoru, Mitsukura, Yasue, Okano, Hideyuki
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Netherlands Elsevier B.V 01.04.2025
Témata:	Aggregation alpha-Synuclein - metabolism Alzheimer disease amyotrophic lateral sclerosis Animals Autophagy Chaperone drugs Humans Intrinsically disordered proteins Intrinsically Disordered Proteins - metabolism Liquid-liquid phase separation Neurodegenerative diseases Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - pathology Parkinson disease proteasome endopeptidase complex Proteasome Endopeptidase Complex - metabolism Proteostasis separation therapeutics toxicity Aggregation Proteostasis Neurodegenerative diseases Intrinsically disordered proteins Chaperone Liquid-liquid phase separation Autophagy
ISSN:	0304-4165, 1872-8006, 1872-8006
On-line přístup:	Získat plný text
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