Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice

Intestinal bacteria may modulate the risk of infection and graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Allo-HSCT recipients often develop neutropenic fever, which is treated with antibiotics that may target anaerobic bacteria in the gut. We...

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Veröffentlicht in:	Science translational medicine Jg. 8; H. 339; S. 339ra71
Hauptverfasser:	Shono, Yusuke, Docampo, Melissa D, Peled, Jonathan U, Perobelli, Suelen M, Velardi, Enrico, Tsai, Jennifer J, Slingerland, Ann E, Smith, Odette M, Young, Lauren F, Gupta, Jyotsna, Lieberman, Sophia R, Jay, Hillary V, Ahr, Katya F, Porosnicu Rodriguez, Kori A, Xu, Ke, Calarfiore, Marco, Poeck, Hendrik, Caballero, Silvia, Devlin, Sean M, Rapaport, Franck, Dudakov, Jarrod A, Hanash, Alan M, Gyurkocza, Boglarka, Murphy, George F, Gomes, Camilla, Liu, Chen, Moss, Eli L, Falconer, Shannon B, Bhatt, Ami S, Taur, Ying, Pamer, Eric G, van den Brink, Marcel R M, Jenq, Robert R
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 18.05.2016
Schlagworte:	Animals Anti-Bacterial Agents CD4-Positive T-Lymphocytes - metabolism Cilastatin - therapeutic use Cilastatin, Imipenem Drug Combination Colon - microbiology Drug Combinations Feces - microbiology Female Flow Cytometry Gastrointestinal Microbiome - drug effects Graft vs Host Disease - etiology Graft vs Host Disease - microbiology Graft vs Host Disease - mortality Hematopoietic Stem Cell Transplantation - adverse effects Humans Imipenem - therapeutic use Interleukin-23 Mice Mice, Inbred C57BL Penicillanic Acid - analogs & derivatives Penicillanic Acid - therapeutic use Phylogeny Piperacillin - therapeutic use Piperacillin, Tazobactam Drug Combination Transplantation, Homologous - adverse effects Verrucomicrobia - classification Verrucomicrobia - drug effects Verrucomicrobia - genetics
ISSN:	1946-6242
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