Histone Ubiquitination by the DNA Damage Response Is Required for Efficient DNA Replication in Unperturbed S Phase

Chromatin ubiquitination by the ubiquitin ligase RNF168 is critical to regulate the DNA damage response (DDR). DDR deficiencies lead to cancer-prone syndromes, but whether this reflects DNA repair defects is still elusive. We identified key factors of the RNF168 pathway as essential mediators of eff...

Celý popis

Podrobná bibliografia

Vydané v:	Molecular cell Ročník 71; číslo 6; s. 897
Hlavní autori:	Schmid, Jonas Andreas, Berti, Matteo, Walser, Franziska, Raso, Maria Chiara, Schmid, Fabian, Krietsch, Jana, Stoy, Henriette, Zwicky, Katharina, Ursich, Sebastian, Freire, Raimundo, Lopes, Massimo, Penengo, Lorenza
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 20.09.2018
Predmet:	RNF168 genome stability fork reversal 53BP1 RIDDLE syndrome RNF8 ataxia telangiectasia ATM H2AK15Ub chromatin ubiquitination
ISSN:	1097-4164, 1097-4164
On-line prístup:	Zistit podrobnosti o prístupe
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!