Histone Ubiquitination by the DNA Damage Response Is Required for Efficient DNA Replication in Unperturbed S Phase

Chromatin ubiquitination by the ubiquitin ligase RNF168 is critical to regulate the DNA damage response (DDR). DDR deficiencies lead to cancer-prone syndromes, but whether this reflects DNA repair defects is still elusive. We identified key factors of the RNF168 pathway as essential mediators of eff...

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Bibliographic Details

Published in:	Molecular cell Vol. 71; no. 6; p. 897
Main Authors:	Schmid, Jonas Andreas, Berti, Matteo, Walser, Franziska, Raso, Maria Chiara, Schmid, Fabian, Krietsch, Jana, Stoy, Henriette, Zwicky, Katharina, Ursich, Sebastian, Freire, Raimundo, Lopes, Massimo, Penengo, Lorenza
Format:	Journal Article
Language:	English
Published:	United States 20.09.2018
Subjects:	RNF168 genome stability fork reversal 53BP1 RIDDLE syndrome RNF8 ataxia telangiectasia ATM H2AK15Ub chromatin ubiquitination
ISSN:	1097-4164, 1097-4164
Online Access:	Get more information
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