Gene-gene and gene-environment interactions in lipodystrophy: Lessons learned from natural PPARγ mutants

Monogenic lipodystrophies are a heterogeneous group of rare disorders characterized by a lack of adipose tissue (AT), all of which predispose patients to the development of insulin resistance and its related metabolic sequelae. The extent of AT loss ranges from partial, as in familial partial lipody...

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Bibliographic Details
Published in:	Biochimica et biophysica acta. Molecular and cell biology of lipids Vol. 1864; no. 5; pp. 715 - 732
Main Authors:	Broekema, M.F., Savage, D.B., Monajemi, H., Kalkhoven, E.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.05.2019
Subjects:	adipocytes Adipose tissue complications (disease) genes Genomic and environmental context insulin resistance Lipodystrophy mutants mutation patients peroxisome proliferator-activated receptor gamma phenotype PPARG FPLD RXRα Adipose tissue Genomic and environmental context DBD PTM CGL PPARγ LBD AT PPRE miRNA Lipodystrophy PPARG TZD
ISSN:	1388-1981, 1879-2618, 1879-2618
Online Access:	Get full text
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