Gene-gene and gene-environment interactions in lipodystrophy: Lessons learned from natural PPARγ mutants

Monogenic lipodystrophies are a heterogeneous group of rare disorders characterized by a lack of adipose tissue (AT), all of which predispose patients to the development of insulin resistance and its related metabolic sequelae. The extent of AT loss ranges from partial, as in familial partial lipody...

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Vydáno v:Biochimica et biophysica acta. Molecular and cell biology of lipids Ročník 1864; číslo 5; s. 715 - 732
Hlavní autoři: Broekema, M.F., Savage, D.B., Monajemi, H., Kalkhoven, E.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Netherlands Elsevier B.V 01.05.2019
Témata:
adipocytes
Adipose tissue
complications (disease)
genes
Genomic and environmental context
insulin resistance
Lipodystrophy
mutants
mutation
patients
peroxisome proliferator-activated receptor gamma
phenotype
PPARG
FPLD
RXRα
Adipose tissue
Genomic and environmental context
DBD
PTM
CGL
PPARγ
LBD
AT
PPRE
miRNA
Lipodystrophy
PPARG
TZD
ISSN:1388-1981, 1879-2618, 1879-2618
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Abstract Monogenic lipodystrophies are a heterogeneous group of rare disorders characterized by a lack of adipose tissue (AT), all of which predispose patients to the development of insulin resistance and its related metabolic sequelae. The extent of AT loss ranges from partial, as in familial partial lipodystrophy (FPLD), to a total absence of metabolically active AT in congenital generalized lipodystrophy (CGL) and is generally associated with the severity of metabolic complications. Significant genetic, allelic, phenotypic, and clinical heterogeneity exists among the lipodystrophies. Patients with FPLD3 due to mutations in the PPARG gene, which encodes a key transcriptional regulator of adipocyte development and function, provide a particularly striking example of this heterogeneity. We will present several gene-gene and gene-environment factors and mechanisms that are critical for adequate PPARγ expression and activity in AT and discuss how these interactions potentially contribute to the observed spectrum of FPLD3 phenotypes. Comparable mechanisms may play a role in other types of lipodystrophies too, and their elucidation may further improve our molecular understanding of AT dysfunction. •Most genetic lipodystrophies are caused by mutations in single genes.•Significant heterogeneity exists among genetic lipodystrophies.•FPLD3, due to PPARG mutations, provides a striking example of the heterogeneity.•Genetic and environmental factors modulate PPARγ; contributing to FPLD3 variability.•Comparable mechanisms likely have a role in other types of lipodystrophies too.
AbstractList Monogenic lipodystrophies are a heterogeneous group of rare disorders characterized by a lack of adipose tissue (AT), all of which predispose patients to the development of insulin resistance and its related metabolic sequelae. The extent of AT loss ranges from partial, as in familial partial lipodystrophy (FPLD), to a total absence of metabolically active AT in congenital generalized lipodystrophy (CGL) and is generally associated with the severity of metabolic complications. Significant genetic, allelic, phenotypic, and clinical heterogeneity exists among the lipodystrophies. Patients with FPLD3 due to mutations in the PPARG gene, which encodes a key transcriptional regulator of adipocyte development and function, provide a particularly striking example of this heterogeneity. We will present several gene-gene and gene-environment factors and mechanisms that are critical for adequate PPARγ expression and activity in AT and discuss how these interactions potentially contribute to the observed spectrum of FPLD3 phenotypes. Comparable mechanisms may play a role in other types of lipodystrophies too, and their elucidation may further improve our molecular understanding of AT dysfunction.Monogenic lipodystrophies are a heterogeneous group of rare disorders characterized by a lack of adipose tissue (AT), all of which predispose patients to the development of insulin resistance and its related metabolic sequelae. The extent of AT loss ranges from partial, as in familial partial lipodystrophy (FPLD), to a total absence of metabolically active AT in congenital generalized lipodystrophy (CGL) and is generally associated with the severity of metabolic complications. Significant genetic, allelic, phenotypic, and clinical heterogeneity exists among the lipodystrophies. Patients with FPLD3 due to mutations in the PPARG gene, which encodes a key transcriptional regulator of adipocyte development and function, provide a particularly striking example of this heterogeneity. We will present several gene-gene and gene-environment factors and mechanisms that are critical for adequate PPARγ expression and activity in AT and discuss how these interactions potentially contribute to the observed spectrum of FPLD3 phenotypes. Comparable mechanisms may play a role in other types of lipodystrophies too, and their elucidation may further improve our molecular understanding of AT dysfunction.
Monogenic lipodystrophies are a heterogeneous group of rare disorders characterized by a lack of adipose tissue (AT), all of which predispose patients to the development of insulin resistance and its related metabolic sequelae. The extent of AT loss ranges from partial, as in familial partial lipodystrophy (FPLD), to a total absence of metabolically active AT in congenital generalized lipodystrophy (CGL) and is generally associated with the severity of metabolic complications. Significant genetic, allelic, phenotypic, and clinical heterogeneity exists among the lipodystrophies. Patients with FPLD3 due to mutations in the PPARG gene, which encodes a key transcriptional regulator of adipocyte development and function, provide a particularly striking example of this heterogeneity. We will present several gene-gene and gene-environment factors and mechanisms that are critical for adequate PPARγ expression and activity in AT and discuss how these interactions potentially contribute to the observed spectrum of FPLD3 phenotypes. Comparable mechanisms may play a role in other types of lipodystrophies too, and their elucidation may further improve our molecular understanding of AT dysfunction.
Monogenic lipodystrophies are a heterogeneous group of rare disorders characterized by a lack of adipose tissue (AT), all of which predispose patients to the development of insulin resistance and its related metabolic sequelae. The extent of AT loss ranges from partial, as in familial partial lipodystrophy (FPLD), to a total absence of metabolically active AT in congenital generalized lipodystrophy (CGL) and is generally associated with the severity of metabolic complications. Significant genetic, allelic, phenotypic, and clinical heterogeneity exists among the lipodystrophies. Patients with FPLD3 due to mutations in the PPARG gene, which encodes a key transcriptional regulator of adipocyte development and function, provide a particularly striking example of this heterogeneity. We will present several gene-gene and gene-environment factors and mechanisms that are critical for adequate PPARγ expression and activity in AT and discuss how these interactions potentially contribute to the observed spectrum of FPLD3 phenotypes. Comparable mechanisms may play a role in other types of lipodystrophies too, and their elucidation may further improve our molecular understanding of AT dysfunction. •Most genetic lipodystrophies are caused by mutations in single genes.•Significant heterogeneity exists among genetic lipodystrophies.•FPLD3, due to PPARG mutations, provides a striking example of the heterogeneity.•Genetic and environmental factors modulate PPARγ; contributing to FPLD3 variability.•Comparable mechanisms likely have a role in other types of lipodystrophies too.
Author Broekema, M.F.
Kalkhoven, E.
Monajemi, H.
Savage, D.B.
Author_xml – sequence: 1
  givenname: M.F.
  surname: Broekema
  fullname: Broekema, M.F.
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  surname: Savage
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  organization: Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom
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  surname: Monajemi
  fullname: Monajemi, H.
  organization: Rijnstate Hospital, Arnhem, the Netherlands
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  surname: Kalkhoven
  fullname: Kalkhoven, E.
  email: e.kalkhoven@umcutrecht.nl
  organization: Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30742913$$D View this record in MEDLINE/PubMed
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Issue 5
Keywords FPLD
RXRα
Adipose tissue
Genomic and environmental context
DBD
PTM
CGL
PPARγ
LBD
AT
PPRE
miRNA
Lipodystrophy
PPARG
TZD
Language English
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Snippet Monogenic lipodystrophies are a heterogeneous group of rare disorders characterized by a lack of adipose tissue (AT), all of which predispose patients to the...
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SubjectTerms adipocytes
Adipose tissue
complications (disease)
genes
Genomic and environmental context
insulin resistance
Lipodystrophy
mutants
mutation
patients
peroxisome proliferator-activated receptor gamma
phenotype
PPARG
Title Gene-gene and gene-environment interactions in lipodystrophy: Lessons learned from natural PPARγ mutants
URI https://dx.doi.org/10.1016/j.bbalip.2019.02.002
https://www.ncbi.nlm.nih.gov/pubmed/30742913
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