Recognition and killing of autologous, primary glioblastoma tumor cells by human cytomegalovirus pp65-specific cytotoxic T cells

Despite aggressive conventional therapy, glioblastoma (GBM) remains uniformly lethal. Immunotherapy, in which the immune system is harnessed to specifically attack malignant cells, offers a treatment option with less toxicity. The expression of cytomegalovirus (CMV) antigens in GBM presents a unique...

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Veröffentlicht in:	Clinical cancer research Jg. 20; H. 10; S. 2684
Hauptverfasser:	Nair, Smita K, De Leon, Gabriel, Boczkowski, David, Schmittling, Robert, Xie, Weihua, Staats, Janet, Liu, Rebecca, Johnson, Laura A, Weinhold, Kent, Archer, Gary E, Sampson, John H, Mitchell, Duane A
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 15.05.2014
Schlagworte:	Blotting, Western Cells, Cultured Coculture Techniques Cytokines - immunology Cytokines - metabolism Cytomegalovirus - immunology Cytomegalovirus - metabolism Cytomegalovirus - physiology Cytotoxicity Tests, Immunologic - methods Cytotoxicity, Immunologic - immunology Dendritic Cells - immunology Dendritic Cells - metabolism Female Flow Cytometry Glioblastoma - immunology Glioblastoma - pathology Glioblastoma - virology Humans Lymphocyte Activation - immunology Male Middle Aged Phosphoproteins - genetics Phosphoproteins - immunology Phosphoproteins - metabolism RNA, Viral - genetics RNA, Viral - immunology T-Lymphocytes - immunology T-Lymphocytes, Cytotoxic - immunology Tumor Cells, Cultured Viral Matrix Proteins - genetics Viral Matrix Proteins - immunology Viral Matrix Proteins - metabolism Young Adult
ISSN:	1557-3265, 1557-3265
Online-Zugang:	Weitere Angaben
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