High dose of prebiotics reduces fecal water cytotoxicity in healthy subjects

Scope In vitro and animal studies have shown differential colonic fermentation of structurally different prebiotics. We evaluated the impact of two structurally different prebiotics (wheat bran extract (WBE, containing arabinoxylan‐oligosaccharides) and oligofructose) on colonic fermentation and mar...

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Vydané v:	Molecular nutrition & food research Ročník 58; číslo 11; s. 2206 - 2218
Hlavní autori:	Windey, Karen, François, Isabelle, Broekaert, Willem, De Preter, Vicky, Delcour, Jan A., Louat, Thierry, Herman, Jean, Verbeke, Kristin
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Weinheim Blackwell Publishing Ltd 01.11.2014 Wiley
Predmet:	Adolescent Adult Aged animals Arabinoxylan-oligosaccharides Biological and medical sciences Body Water - chemistry cluster analysis Colon - metabolism Comet Assay Cross-Over Studies cytotoxicity digestive system DNA Damage Double-Blind Method Fecal water toxicity Feces - chemistry Feces - microbiology Feeding. Feeding behavior Female Fermentation Follow-Up Studies fructooligosaccharides Fundamental and applied biological sciences. Psychology genotoxicity Healthy Volunteers Humans Male metabolomics Middle Aged Oligofructose Oligosaccharides - administration & dosage p-cresol placebos Prebiotics randomized clinical trials Vertebrates: anatomy and physiology, studies on body, several organs or systems volunteers wheat bran Xylans - administration & dosage Young Adult Water Healthy subject Nutrition Toxicity Oligosaccharide Fecal water toxicity Cytotoxicity Arabinoxylan-oligosaccharides Fermentation High dose Oligofructose
ISSN:	1613-4125, 1613-4133, 1613-4133
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Shrnutí:	Scope In vitro and animal studies have shown differential colonic fermentation of structurally different prebiotics. We evaluated the impact of two structurally different prebiotics (wheat bran extract (WBE, containing arabinoxylan‐oligosaccharides) and oligofructose) on colonic fermentation and markers of bowel health in healthy volunteers. Methods and results Nineteen healthy subjects completed a double‐blind, cross‐over randomized controlled trial. Interventions with WBE, oligofructose or placebo for 2 wk (week 1: 15 g/day; week 2: 30 g/day) were separated by 2‐wk wash‐out periods. At the end of each study period, colonic fermentation was characterized through a metabolomics approach. Fecal water genotoxicity and cytotoxicity were determined using the comet and WST‐1 assay, respectively, as parameters of gut health. Cluster analysis revealed differences in effects of WBE and oligofructose on colonic fermentation. WBE, but not oligofructose, reduced fecal p‐cresol (p = 0.009) and isovaleric acid concentrations (p = 0.022), markers of protein fermentation. Fecal water cytotoxicity was significantly lower after intake of WBE (p = 0.015). Both WBE‐ and oligofructose‐intake tended to reduce fecal water genotoxicity compared to placebo (WBE: p = 0.060; oligofructose: p = 0.057). Changes in fermentation were not related to changes in fecal water toxicity. Conclusion Structurally different prebiotics affect colonic fermentation and gut health in a different way.
Bibliografia:	ArticleID:MNFR2258 istex:C8FC9B5CA7A2440CA1487AE22DA0BCB17E7FEFA6 ark:/67375/WNG-GSPQNKK8-L ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3
ISSN:	1613-4125 1613-4133 1613-4133
DOI:	10.1002/mnfr.201400298