High dose of prebiotics reduces fecal water cytotoxicity in healthy subjects

Scope In vitro and animal studies have shown differential colonic fermentation of structurally different prebiotics. We evaluated the impact of two structurally different prebiotics (wheat bran extract (WBE, containing arabinoxylan‐oligosaccharides) and oligofructose) on colonic fermentation and mar...

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Veröffentlicht in:Molecular nutrition & food research Jg. 58; H. 11; S. 2206 - 2218
Hauptverfasser: Windey, Karen, François, Isabelle, Broekaert, Willem, De Preter, Vicky, Delcour, Jan A., Louat, Thierry, Herman, Jean, Verbeke, Kristin
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Weinheim Blackwell Publishing Ltd 01.11.2014
Wiley
Schlagworte:
Adolescent
Adult
Aged
animals
Arabinoxylan-oligosaccharides
Biological and medical sciences
Body Water - chemistry
cluster analysis
Colon - metabolism
Comet Assay
Cross-Over Studies
cytotoxicity
digestive system
DNA Damage
Double-Blind Method
Fecal water toxicity
Feces - chemistry
Feces - microbiology
Feeding. Feeding behavior
Female
Fermentation
Follow-Up Studies
fructooligosaccharides
Fundamental and applied biological sciences. Psychology
genotoxicity
Healthy Volunteers
Humans
Male
metabolomics
Middle Aged
Oligofructose
Oligosaccharides - administration & dosage
p-cresol
placebos
Prebiotics
randomized clinical trials
Vertebrates: anatomy and physiology, studies on body, several organs or systems
volunteers
wheat bran
Xylans - administration & dosage
Young Adult
Water
Healthy subject
Nutrition
Toxicity
Oligosaccharide
Fecal water toxicity
Cytotoxicity
Arabinoxylan-oligosaccharides
Fermentation
High dose
Oligofructose
ISSN:1613-4125, 1613-4133, 1613-4133
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Zusammenfassung:Scope In vitro and animal studies have shown differential colonic fermentation of structurally different prebiotics. We evaluated the impact of two structurally different prebiotics (wheat bran extract (WBE, containing arabinoxylan‐oligosaccharides) and oligofructose) on colonic fermentation and markers of bowel health in healthy volunteers. Methods and results Nineteen healthy subjects completed a double‐blind, cross‐over randomized controlled trial. Interventions with WBE, oligofructose or placebo for 2 wk (week 1: 15 g/day; week 2: 30 g/day) were separated by 2‐wk wash‐out periods. At the end of each study period, colonic fermentation was characterized through a metabolomics approach. Fecal water genotoxicity and cytotoxicity were determined using the comet and WST‐1 assay, respectively, as parameters of gut health. Cluster analysis revealed differences in effects of WBE and oligofructose on colonic fermentation. WBE, but not oligofructose, reduced fecal p‐cresol (p = 0.009) and isovaleric acid concentrations (p = 0.022), markers of protein fermentation. Fecal water cytotoxicity was significantly lower after intake of WBE (p = 0.015). Both WBE‐ and oligofructose‐intake tended to reduce fecal water genotoxicity compared to placebo (WBE: p = 0.060; oligofructose: p = 0.057). Changes in fermentation were not related to changes in fecal water toxicity. Conclusion Structurally different prebiotics affect colonic fermentation and gut health in a different way.
Bibliographie:ArticleID:MNFR2258
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SourceType-Scholarly Journals-1
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content type line 23
ObjectType-Undefined-3
ISSN:1613-4125
1613-4133
1613-4133
DOI:10.1002/mnfr.201400298