High dose of prebiotics reduces fecal water cytotoxicity in healthy subjects

Scope In vitro and animal studies have shown differential colonic fermentation of structurally different prebiotics. We evaluated the impact of two structurally different prebiotics (wheat bran extract (WBE, containing arabinoxylan‐oligosaccharides) and oligofructose) on colonic fermentation and mar...

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Published in:	Molecular nutrition & food research Vol. 58; no. 11; pp. 2206 - 2218
Main Authors:	Windey, Karen, François, Isabelle, Broekaert, Willem, De Preter, Vicky, Delcour, Jan A., Louat, Thierry, Herman, Jean, Verbeke, Kristin
Format:	Journal Article
Language:	English
Published:	Weinheim Blackwell Publishing Ltd 01.11.2014 Wiley
Subjects:	Adolescent Adult Aged animals Arabinoxylan-oligosaccharides Biological and medical sciences Body Water - chemistry cluster analysis Colon - metabolism Comet Assay Cross-Over Studies cytotoxicity digestive system DNA Damage Double-Blind Method Fecal water toxicity Feces - chemistry Feces - microbiology Feeding. Feeding behavior Female Fermentation Follow-Up Studies fructooligosaccharides Fundamental and applied biological sciences. Psychology genotoxicity Healthy Volunteers Humans Male metabolomics Middle Aged Oligofructose Oligosaccharides - administration & dosage p-cresol placebos Prebiotics randomized clinical trials Vertebrates: anatomy and physiology, studies on body, several organs or systems volunteers wheat bran Xylans - administration & dosage Young Adult Water Healthy subject Nutrition Toxicity Oligosaccharide Fecal water toxicity Cytotoxicity Arabinoxylan-oligosaccharides Fermentation High dose Oligofructose
ISSN:	1613-4125, 1613-4133, 1613-4133
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Abstract	Scope In vitro and animal studies have shown differential colonic fermentation of structurally different prebiotics. We evaluated the impact of two structurally different prebiotics (wheat bran extract (WBE, containing arabinoxylan‐oligosaccharides) and oligofructose) on colonic fermentation and markers of bowel health in healthy volunteers. Methods and results Nineteen healthy subjects completed a double‐blind, cross‐over randomized controlled trial. Interventions with WBE, oligofructose or placebo for 2 wk (week 1: 15 g/day; week 2: 30 g/day) were separated by 2‐wk wash‐out periods. At the end of each study period, colonic fermentation was characterized through a metabolomics approach. Fecal water genotoxicity and cytotoxicity were determined using the comet and WST‐1 assay, respectively, as parameters of gut health. Cluster analysis revealed differences in effects of WBE and oligofructose on colonic fermentation. WBE, but not oligofructose, reduced fecal p‐cresol (p = 0.009) and isovaleric acid concentrations (p = 0.022), markers of protein fermentation. Fecal water cytotoxicity was significantly lower after intake of WBE (p = 0.015). Both WBE‐ and oligofructose‐intake tended to reduce fecal water genotoxicity compared to placebo (WBE: p = 0.060; oligofructose: p = 0.057). Changes in fermentation were not related to changes in fecal water toxicity. Conclusion Structurally different prebiotics affect colonic fermentation and gut health in a different way.
AbstractList	In vitro and animal studies have shown differential colonic fermentation of structurally different prebiotics. We evaluated the impact of two structurally different prebiotics (wheat bran extract (WBE, containing arabinoxylan-oligosaccharides) and oligofructose) on colonic fermentation and markers of bowel health in healthy volunteers.SCOPEIn vitro and animal studies have shown differential colonic fermentation of structurally different prebiotics. We evaluated the impact of two structurally different prebiotics (wheat bran extract (WBE, containing arabinoxylan-oligosaccharides) and oligofructose) on colonic fermentation and markers of bowel health in healthy volunteers.Nineteen healthy subjects completed a double-blind, cross-over randomized controlled trial. Interventions with WBE, oligofructose or placebo for 2 wk (week 1: 15 g/day; week 2: 30 g/day) were separated by 2-wk wash-out periods. At the end of each study period, colonic fermentation was characterized through a metabolomics approach. Fecal water genotoxicity and cytotoxicity were determined using the comet and WST-1 assay, respectively, as parameters of gut health. Cluster analysis revealed differences in effects of WBE and oligofructose on colonic fermentation. WBE, but not oligofructose, reduced fecal p-cresol (p = 0.009) and isovaleric acid concentrations (p = 0.022), markers of protein fermentation. Fecal water cytotoxicity was significantly lower after intake of WBE (p = 0.015). Both WBE- and oligofructose-intake tended to reduce fecal water genotoxicity compared to placebo (WBE: p = 0.060; oligofructose: p = 0.057). Changes in fermentation were not related to changes in fecal water toxicity.METHODS AND RESULTSNineteen healthy subjects completed a double-blind, cross-over randomized controlled trial. Interventions with WBE, oligofructose or placebo for 2 wk (week 1: 15 g/day; week 2: 30 g/day) were separated by 2-wk wash-out periods. At the end of each study period, colonic fermentation was characterized through a metabolomics approach. Fecal water genotoxicity and cytotoxicity were determined using the comet and WST-1 assay, respectively, as parameters of gut health. Cluster analysis revealed differences in effects of WBE and oligofructose on colonic fermentation. WBE, but not oligofructose, reduced fecal p-cresol (p = 0.009) and isovaleric acid concentrations (p = 0.022), markers of protein fermentation. Fecal water cytotoxicity was significantly lower after intake of WBE (p = 0.015). Both WBE- and oligofructose-intake tended to reduce fecal water genotoxicity compared to placebo (WBE: p = 0.060; oligofructose: p = 0.057). Changes in fermentation were not related to changes in fecal water toxicity.Structurally different prebiotics affect colonic fermentation and gut health in a different way.CONCLUSIONStructurally different prebiotics affect colonic fermentation and gut health in a different way. Scope In vitro and animal studies have shown differential colonic fermentation of structurally different prebiotics. We evaluated the impact of two structurally different prebiotics (wheat bran extract (WBE, containing arabinoxylan‐oligosaccharides) and oligofructose) on colonic fermentation and markers of bowel health in healthy volunteers. Methods and results Nineteen healthy subjects completed a double‐blind, cross‐over randomized controlled trial. Interventions with WBE, oligofructose or placebo for 2 wk (week 1: 15 g/day; week 2: 30 g/day) were separated by 2‐wk wash‐out periods. At the end of each study period, colonic fermentation was characterized through a metabolomics approach. Fecal water genotoxicity and cytotoxicity were determined using the comet and WST‐1 assay, respectively, as parameters of gut health. Cluster analysis revealed differences in effects of WBE and oligofructose on colonic fermentation. WBE, but not oligofructose, reduced fecal p‐cresol (p = 0.009) and isovaleric acid concentrations (p = 0.022), markers of protein fermentation. Fecal water cytotoxicity was significantly lower after intake of WBE (p = 0.015). Both WBE‐ and oligofructose‐intake tended to reduce fecal water genotoxicity compared to placebo (WBE: p = 0.060; oligofructose: p = 0.057). Changes in fermentation were not related to changes in fecal water toxicity. Conclusion Structurally different prebiotics affect colonic fermentation and gut health in a different way. In vitro and animal studies have shown differential colonic fermentation of structurally different prebiotics. We evaluated the impact of two structurally different prebiotics (wheat bran extract (WBE, containing arabinoxylan-oligosaccharides) and oligofructose) on colonic fermentation and markers of bowel health in healthy volunteers. Nineteen healthy subjects completed a double-blind, cross-over randomized controlled trial. Interventions with WBE, oligofructose or placebo for 2 wk (week 1: 15 g/day; week 2: 30 g/day) were separated by 2-wk wash-out periods. At the end of each study period, colonic fermentation was characterized through a metabolomics approach. Fecal water genotoxicity and cytotoxicity were determined using the comet and WST-1 assay, respectively, as parameters of gut health. Cluster analysis revealed differences in effects of WBE and oligofructose on colonic fermentation. WBE, but not oligofructose, reduced fecal p-cresol (p = 0.009) and isovaleric acid concentrations (p = 0.022), markers of protein fermentation. Fecal water cytotoxicity was significantly lower after intake of WBE (p = 0.015). Both WBE- and oligofructose-intake tended to reduce fecal water genotoxicity compared to placebo (WBE: p = 0.060; oligofructose: p = 0.057). Changes in fermentation were not related to changes in fecal water toxicity. Structurally different prebiotics affect colonic fermentation and gut health in a different way. SCOPE: In vitro and animal studies have shown differential colonic fermentation of structurally different prebiotics. We evaluated the impact of two structurally different prebiotics (wheat bran extract (WBE, containing arabinoxylan‐oligosaccharides) and oligofructose) on colonic fermentation and markers of bowel health in healthy volunteers. METHODS AND RESULTS: Nineteen healthy subjects completed a double‐blind, cross‐over randomized controlled trial. Interventions with WBE, oligofructose or placebo for 2 wk (week 1: 15 g/day; week 2: 30 g/day) were separated by 2‐wk wash‐out periods. At the end of each study period, colonic fermentation was characterized through a metabolomics approach. Fecal water genotoxicity and cytotoxicity were determined using the comet and WST‐1 assay, respectively, as parameters of gut health. Cluster analysis revealed differences in effects of WBE and oligofructose on colonic fermentation. WBE, but not oligofructose, reduced fecal p‐cresol (p = 0.009) and isovaleric acid concentrations (p = 0.022), markers of protein fermentation. Fecal water cytotoxicity was significantly lower after intake of WBE (p = 0.015). Both WBE‐ and oligofructose‐intake tended to reduce fecal water genotoxicity compared to placebo (WBE: p = 0.060; oligofructose: p = 0.057). Changes in fermentation were not related to changes in fecal water toxicity. CONCLUSION: Structurally different prebiotics affect colonic fermentation and gut health in a different way.
Author	Herman, Jean Verbeke, Kristin François, Isabelle De Preter, Vicky Windey, Karen Broekaert, Willem Louat, Thierry Delcour, Jan A.
Author_xml	– sequence: 1 givenname: Karen surname: Windey fullname: Windey, Karen organization: Translational Research Center for Gastrointestinal Disorders (TARGID), KULeuven, Leuven, Belgium – sequence: 2 givenname: Isabelle surname: François fullname: François, Isabelle organization: Fugeia NV, Leuven, Belgium – sequence: 3 givenname: Willem surname: Broekaert fullname: Broekaert, Willem organization: Fugeia NV, Leuven, Belgium – sequence: 4 givenname: Vicky surname: De Preter fullname: De Preter, Vicky organization: Translational Research Center for Gastrointestinal Disorders (TARGID), KULeuven, Leuven, Belgium – sequence: 5 givenname: Jan A. surname: Delcour fullname: Delcour, Jan A. organization: Leuven Food Science and Nutrition Research Centre (LFoRCe), KULeuven, Leuven, Belgium – sequence: 6 givenname: Thierry surname: Louat fullname: Louat, Thierry organization: Interface Valorisation Platform (IVAP), KULeuven, Leuven, Belgium – sequence: 7 givenname: Jean surname: Herman fullname: Herman, Jean organization: Interface Valorisation Platform (IVAP), KULeuven, Leuven, Belgium – sequence: 8 givenname: Kristin surname: Verbeke fullname: Verbeke, Kristin email: Kristin.Verbeke@med.kuleuven.be organization: Translational Research Center for Gastrointestinal Disorders (TARGID), KULeuven, Leuven, Belgium
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Keywords	Water Healthy subject Nutrition Toxicity Oligosaccharide Fecal water toxicity Cytotoxicity Arabinoxylan-oligosaccharides Fermentation High dose Oligofructose
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Snippet	Scope In vitro and animal studies have shown differential colonic fermentation of structurally different prebiotics. We evaluated the impact of two... In vitro and animal studies have shown differential colonic fermentation of structurally different prebiotics. We evaluated the impact of two structurally... SCOPE: In vitro and animal studies have shown differential colonic fermentation of structurally different prebiotics. We evaluated the impact of two...
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SubjectTerms	Adolescent Adult Aged animals Arabinoxylan-oligosaccharides Biological and medical sciences Body Water - chemistry cluster analysis Colon - metabolism Comet Assay Cross-Over Studies cytotoxicity digestive system DNA Damage Double-Blind Method Fecal water toxicity Feces - chemistry Feces - microbiology Feeding. Feeding behavior Female Fermentation Follow-Up Studies fructooligosaccharides Fundamental and applied biological sciences. Psychology genotoxicity Healthy Volunteers Humans Male metabolomics Middle Aged Oligofructose Oligosaccharides - administration & dosage p-cresol placebos Prebiotics randomized clinical trials Vertebrates: anatomy and physiology, studies on body, several organs or systems volunteers wheat bran Xylans - administration & dosage Young Adult
Title	High dose of prebiotics reduces fecal water cytotoxicity in healthy subjects
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