Prostaglandin E2 Promotes Features of Replicative Senescence in Chronically Activated Human CD8+ T Cells

Prostaglandin E2 (PGE2), a pleiotropic immunomodulatory molecule, and its free radical catalyzed isoform, iso-PGE2, are frequently elevated in the context of cancer and chronic infection. Previous studies have documented the effects of PGE2 on the various CD4+ T cell functions, but little is known a...

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Bibliographic Details
Published in:	PloS one Vol. 9; no. 6; p. e99432
Main Authors:	Chou, Jennifer P., Ramirez, Christina M., Ryba, Danielle M., Koduri, Megha P., Effros, Rita B.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 11.06.2014 Public Library of Science (PLoS)
Subjects:	Acquired immune deficiency syndrome Aging AIDS Antigens Base Sequence Biology and Life Sciences Cancer CD28 antigen CD4 antigen CD8 antigen CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - metabolism Cell activation Cell cycle Cell Cycle - genetics Cell growth Cell survival Cellular Senescence Chronic infection Cyclic AMP - metabolism Cyclooxygenase-2 Cytokines Cytotoxicity Dinoprostone - physiology DNA Primers Feedback loops Flow Cytometry Gene expression Genes, p16 HIV Human immunodeficiency virus Humans Immune system Immunomodulation Infections Laboratories Lymphocyte Activation Lymphocytes Lymphocytes T Medicine Negative feedback Oxidative stress Oxygen Pathology Polymerase Chain Reaction Prostaglandin E2 Reactive oxygen species Reactive Oxygen Species - metabolism Senescence Telomerase Transcription, Genetic Tumor cells Los Angeles California United States > US California
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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