Estimation of serum TSH receptor autoantibody concentration and affinity

We have used the human monoclonal TSH receptor (TSHR) autoantibody (M22) as a labeled ligand in competition with individual patient TSHR autoantibodies (TRAb) to estimate their serum concentrations and affinities. TSHR coated tubes, (125)I-labeled M22 IgG and Fab, and patient sera IgG and Fab were u...

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Bibliographic Details
Published in:	Thyroid (New York, N.Y.) Vol. 16; no. 11; p. 1077
Main Authors:	Nakatake, Nobuhiro, Sanders, Jane, Richards, Tonya, Burne, Peter, Barrett, Carol, Pra, Chiara Dal, Presotto, Fabio, Betterle, Corrado, Furmaniak, Jadwiga, Smith, Bernard Rees
Format:	Journal Article
Language:	English
Published:	United States 01.11.2006
Subjects:	Antibodies, Monoclonal - pharmacology Antibody Affinity Autoantibodies - blood Binding, Competitive - immunology Chromatography, Affinity Graves Disease - immunology Humans Immunoglobulin Fab Fragments - blood Immunoglobulin Fab Fragments - pharmacology Immunoglobulin G - blood Immunoglobulin G - pharmacology Immunoglobulins, Thyroid-Stimulating Iodine Radioisotopes Receptors, Thyrotropin - immunology Receptors, Thyrotropin - metabolism Thyrotoxicosis - immunology
ISSN:	1050-7256
Online Access:	Get more information
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