Hepatitis B virus genotypes: global distribution and clinical importance
At least 600000 individuals worldwide annually die of hepatitis B virus (HBV)-related diseases, such as chronic hepatitis B (CHB), liver cirrhosis (LC), and hepatocellular carcinoma (HCC). Many viral factors, such as viral load, genotype, and specific viral mutations, are known to affect disease pro...
Uložené v:
| Vydané v: | World journal of gastroenterology : WJG Ročník 20; číslo 18; s. 5427 |
|---|---|
| Hlavný autor: | |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
United States
14.05.2014
|
| Predmet: | |
| ISSN: | 2219-2840, 2219-2840 |
| On-line prístup: | Zistit podrobnosti o prístupe |
| Tagy: |
Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
|
| Abstract | At least 600000 individuals worldwide annually die of hepatitis B virus (HBV)-related diseases, such as chronic hepatitis B (CHB), liver cirrhosis (LC), and hepatocellular carcinoma (HCC). Many viral factors, such as viral load, genotype, and specific viral mutations, are known to affect disease progression. HBV reverse transcriptase does not have a proofreading function, therefore, many HBV genotypes, sub-genotypes, mutants, and recombinants emerge. Differences between genotypes in response to antiviral treatment have been determined. To date, 10 HBV genotypes, scattered across different geographical regions, have been identified. For example, genotype A has a tendency for chronicity, whereas viral mutations are frequently encountered in genotype C. Both chronicity and mutation frequency are common in genotype D. LC and progression to HCC are more commonly encountered with genotypes C and D than the other genotypes. Pathogenic differences between HBV genotypes explain disease intensity, progression to LC, and HCC. In conclusion, genotype determination in CHB infection is important in estimating disease progression and planning optimal antiviral treatment. |
|---|---|
| AbstractList | At least 600000 individuals worldwide annually die of hepatitis B virus (HBV)-related diseases, such as chronic hepatitis B (CHB), liver cirrhosis (LC), and hepatocellular carcinoma (HCC). Many viral factors, such as viral load, genotype, and specific viral mutations, are known to affect disease progression. HBV reverse transcriptase does not have a proofreading function, therefore, many HBV genotypes, sub-genotypes, mutants, and recombinants emerge. Differences between genotypes in response to antiviral treatment have been determined. To date, 10 HBV genotypes, scattered across different geographical regions, have been identified. For example, genotype A has a tendency for chronicity, whereas viral mutations are frequently encountered in genotype C. Both chronicity and mutation frequency are common in genotype D. LC and progression to HCC are more commonly encountered with genotypes C and D than the other genotypes. Pathogenic differences between HBV genotypes explain disease intensity, progression to LC, and HCC. In conclusion, genotype determination in CHB infection is important in estimating disease progression and planning optimal antiviral treatment. At least 600000 individuals worldwide annually die of hepatitis B virus (HBV)-related diseases, such as chronic hepatitis B (CHB), liver cirrhosis (LC), and hepatocellular carcinoma (HCC). Many viral factors, such as viral load, genotype, and specific viral mutations, are known to affect disease progression. HBV reverse transcriptase does not have a proofreading function, therefore, many HBV genotypes, sub-genotypes, mutants, and recombinants emerge. Differences between genotypes in response to antiviral treatment have been determined. To date, 10 HBV genotypes, scattered across different geographical regions, have been identified. For example, genotype A has a tendency for chronicity, whereas viral mutations are frequently encountered in genotype C. Both chronicity and mutation frequency are common in genotype D. LC and progression to HCC are more commonly encountered with genotypes C and D than the other genotypes. Pathogenic differences between HBV genotypes explain disease intensity, progression to LC, and HCC. In conclusion, genotype determination in CHB infection is important in estimating disease progression and planning optimal antiviral treatment.At least 600000 individuals worldwide annually die of hepatitis B virus (HBV)-related diseases, such as chronic hepatitis B (CHB), liver cirrhosis (LC), and hepatocellular carcinoma (HCC). Many viral factors, such as viral load, genotype, and specific viral mutations, are known to affect disease progression. HBV reverse transcriptase does not have a proofreading function, therefore, many HBV genotypes, sub-genotypes, mutants, and recombinants emerge. Differences between genotypes in response to antiviral treatment have been determined. To date, 10 HBV genotypes, scattered across different geographical regions, have been identified. For example, genotype A has a tendency for chronicity, whereas viral mutations are frequently encountered in genotype C. Both chronicity and mutation frequency are common in genotype D. LC and progression to HCC are more commonly encountered with genotypes C and D than the other genotypes. Pathogenic differences between HBV genotypes explain disease intensity, progression to LC, and HCC. In conclusion, genotype determination in CHB infection is important in estimating disease progression and planning optimal antiviral treatment. |
| Author | Sunbul, Mustafa |
| Author_xml | – sequence: 1 givenname: Mustafa surname: Sunbul fullname: Sunbul, Mustafa organization: Mustafa Sunbul, Department of Infectious Diseases, School of Medicine, Ondokuz Mayis University, 55139 Samsun, Turkey |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24833873$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNj0tLw0AYRQep2IfuXUmWbhLnlcyMOy1qhYIbXYd5fC1TkknMTCr99y1YwdU9cA8X7hxNQhcAoVuCCya4fPjZbYs9xYUnsig5FRdoRilROZUcT_7xFM1j3GFMGSvpFZpSLhmTgs3QagW9Tj75mD1nez-MMdtC6NKhh_iYbZvO6CZzPqbBmzH5LmQ6uMw2Pnh7anzbd0PSwcI1utzoJsLNORfo6_Xlc7nK1x9v78undW45xykHhgUIhc1GVaAqQwgxG0NA8ApYCdIyh03lNJZOlEbaiihuJNYVI446ZukC3f_u9kP3PUJMdeujhabRAbox1qRkileKMXxS787qaFpwdT_4Vg-H-u89PQJuh18K |
| CitedBy_id | crossref_primary_10_3390_v11090860 crossref_primary_10_3390_ijms241310547 crossref_primary_10_12688_f1000research_128116_2 crossref_primary_10_12688_f1000research_128116_1 crossref_primary_10_3390_genes9090420 crossref_primary_10_1002_jmv_25353 crossref_primary_10_1371_journal_pone_0172101 crossref_primary_10_1093_carcin_bgx145 crossref_primary_10_1038_srep13734 crossref_primary_10_3390_microorganisms12030599 crossref_primary_10_1111_jvh_13014 crossref_primary_10_1186_s12929_018_0442_4 crossref_primary_10_1371_journal_pone_0188944 crossref_primary_10_1002_jmv_24828 crossref_primary_10_3390_microorganisms10122381 crossref_primary_10_1038_s41598_017_07642_6 crossref_primary_10_3390_v15081729 crossref_primary_10_1002_jmv_24942 crossref_primary_10_1111_liv_15249 crossref_primary_10_33549_physiolres_934979 crossref_primary_10_3748_wjg_v22_i17_4287 crossref_primary_10_1080_14656566_2022_2144219 crossref_primary_10_1016_j_humimm_2025_111293 crossref_primary_10_3390_v13020245 crossref_primary_10_1111_brv_12457 crossref_primary_10_3748_wjg_v21_i21_6684 crossref_primary_10_1128_AAC_00082_18 crossref_primary_10_3389_fmicb_2021_663534 crossref_primary_10_3389_fmicb_2022_1020147 crossref_primary_10_3390_pathogens8020063 crossref_primary_10_1016_j_virusres_2017_12_007 crossref_primary_10_1016_j_jcv_2018_04_005 crossref_primary_10_4102_ajlm_v11i1_1677 crossref_primary_10_1016_j_rdc_2018_06_006 crossref_primary_10_1371_journal_pone_0291378 crossref_primary_10_1155_2019_1475163 crossref_primary_10_1007_s00705_017_3632_6 crossref_primary_10_3138_canlivj_2023_0003 crossref_primary_10_3390_pathogens10101333 crossref_primary_10_1016_j_tim_2018_08_011 crossref_primary_10_1186_s12879_025_11226_5 crossref_primary_10_3389_fcimb_2021_590989 crossref_primary_10_1186_s12879_025_11166_0 crossref_primary_10_1097_MEG_0000000000001357 crossref_primary_10_3851_IMP3055 crossref_primary_10_3390_v14051085 crossref_primary_10_1007_s12072_016_9779_5 crossref_primary_10_3390_microorganisms9122607 crossref_primary_10_3390_diagnostics12102393 crossref_primary_10_1093_nar_gkx823 crossref_primary_10_1016_j_jiph_2023_12_020 crossref_primary_10_1016_j_jinf_2020_07_019 crossref_primary_10_1016_j_gastha_2023_10_008 crossref_primary_10_3389_fimmu_2019_01735 crossref_primary_10_3389_fimmu_2022_1034968 crossref_primary_10_1016_j_antiviral_2018_12_021 crossref_primary_10_5812_hepatmon_34420 crossref_primary_10_1016_j_jiph_2020_11_016 crossref_primary_10_1186_s12879_020_05269_z crossref_primary_10_1186_s12889_023_15130_y crossref_primary_10_1016_j_jcv_2018_01_011 crossref_primary_10_1053_j_gastro_2018_11_037 crossref_primary_10_3389_fgwh_2023_1184090 crossref_primary_10_3389_fimmu_2022_1032716 crossref_primary_10_1016_j_apsusc_2014_06_084 crossref_primary_10_1038_s41598_017_02012_8 crossref_primary_10_1016_j_jcv_2017_08_001 crossref_primary_10_1371_journal_pone_0265063 crossref_primary_10_1186_s12889_022_14296_1 crossref_primary_10_5812_hepatmon_34790 crossref_primary_10_3390_jcm12216807 crossref_primary_10_1016_j_vaccine_2022_03_049 crossref_primary_10_3389_fimmu_2020_02074 crossref_primary_10_3390_jcm14082618 crossref_primary_10_3390_pathogens11010020 crossref_primary_10_2478_rrlm_2020_0010 crossref_primary_10_1016_j_addr_2020_05_010 crossref_primary_10_5812_hepatmon_12472 crossref_primary_10_1093_cid_ciz1170 crossref_primary_10_1016_j_jhep_2022_01_007 crossref_primary_10_1016_j_gtc_2019_02_007 crossref_primary_10_1016_j_jhep_2017_07_011 crossref_primary_10_1002_ijc_70092 crossref_primary_10_1007_s11262_018_1610_z crossref_primary_10_1016_S2468_1253_24_00237_1 crossref_primary_10_1111_aogs_14448 crossref_primary_10_1016_j_coviro_2018_03_006 crossref_primary_10_1016_j_vaccine_2020_09_083 crossref_primary_10_1053_j_ackd_2018_10_004 crossref_primary_10_4103_ijmr_ijmr_444_22 crossref_primary_10_1097_IPC_0000000000000990 crossref_primary_10_1016_j_mvr_2019_103970 crossref_primary_10_1016_j_ijmmb_2021_04_012 crossref_primary_10_1099_jgv_0_000789 crossref_primary_10_1111_hepr_12981 crossref_primary_10_3390_v16050724 crossref_primary_10_1089_vim_2020_0176 crossref_primary_10_1016_j_meegid_2018_06_013 crossref_primary_10_5812_hepatmon_43838 crossref_primary_10_3390_ijms222011051 crossref_primary_10_1002_anie_202403123 crossref_primary_10_1093_ve_veaa006 crossref_primary_10_1371_journal_pone_0197109 crossref_primary_10_1016_j_jmoldx_2018_03_001 crossref_primary_10_1016_j_cld_2018_06_002 crossref_primary_10_1016_j_meegid_2022_105371 crossref_primary_10_4274_jcrpe_galenos_2021_2021_8_4 crossref_primary_10_1016_j_jiph_2016_02_006 crossref_primary_10_1111_1348_0421_12947 crossref_primary_10_3389_fmicb_2022_837746 crossref_primary_10_1002_hep_30050 crossref_primary_10_1016_j_virol_2017_10_016 crossref_primary_10_1016_j_virusres_2017_09_025 crossref_primary_10_3390_vaccines12050488 crossref_primary_10_1002_ange_202403123 crossref_primary_10_33073_pjm_2019_044 crossref_primary_10_1016_j_coviro_2016_09_012 crossref_primary_10_3389_fimmu_2017_01285 crossref_primary_10_1186_s12985_015_0313_5 crossref_primary_10_1016_j_meegid_2024_105618 crossref_primary_10_1097_FPC_0000000000000187 crossref_primary_10_2147_IDR_S335666 crossref_primary_10_12688_wellcomeopenres_9952_1 crossref_primary_10_1111_ijcp_14812 crossref_primary_10_1111_jvh_13485 crossref_primary_10_1186_s12879_016_2149_z crossref_primary_10_3390_v15122395 crossref_primary_10_1016_j_jbc_2021_100589 crossref_primary_10_1016_j_jcv_2015_09_004 crossref_primary_10_1016_j_yamp_2018_06_006 crossref_primary_10_36233_0372_9311_578 crossref_primary_10_3748_wjg_v23_i2_306 crossref_primary_10_1016_j_sjbs_2021_11_012 crossref_primary_10_1111_liv_16048 crossref_primary_10_1016_j_actatropica_2024_107318 crossref_primary_10_3390_cancers13102454 crossref_primary_10_3390_vaccines13090916 crossref_primary_10_1016_j_bjid_2022_102367 crossref_primary_10_1097_MD_0000000000020302 crossref_primary_10_1038_s41598_025_17245_1 crossref_primary_10_1515_cclm_2017_1133 crossref_primary_10_3390_ph17070964 crossref_primary_10_1016_j_jhep_2018_11_010 crossref_primary_10_1080_13557858_2022_2040957 crossref_primary_10_3390_v16060954 crossref_primary_10_1111_jvh_13099 crossref_primary_10_1155_2017_1096406 crossref_primary_10_1007_s12072_021_10162_1 crossref_primary_10_3390_ijms24054964 crossref_primary_10_1111_hepr_13768 crossref_primary_10_1186_s12879_015_1096_4 crossref_primary_10_1080_13102818_2015_1093430 crossref_primary_10_1136_gutjnl_2020_322719 crossref_primary_10_4254_wjh_v10_i11_807 crossref_primary_10_1111_jgh_12831 crossref_primary_10_1007_s11262_024_02115_1 crossref_primary_10_1016_j_jcv_2020_104527 crossref_primary_10_1016_j_meegid_2016_06_002 crossref_primary_10_3389_fimmu_2019_01319 crossref_primary_10_3390_v9080199 crossref_primary_10_1111_apm_12704 crossref_primary_10_1002_hep4_1595 crossref_primary_10_1007_s00705_018_3764_3 crossref_primary_10_1111_hepr_13194 crossref_primary_10_1111_1751_2980_13172 crossref_primary_10_3390_genes9100495 crossref_primary_10_1177_0009922816650599 crossref_primary_10_3390_microorganisms11081908 crossref_primary_10_1007_s00705_020_04686_4 crossref_primary_10_7554_eLife_26738 crossref_primary_10_1371_journal_pone_0276618 crossref_primary_10_1016_j_virusres_2018_07_014 crossref_primary_10_1186_s12879_020_05025_3 crossref_primary_10_1089_omi_2023_0171 crossref_primary_10_1177_0956462419849252 crossref_primary_10_3390_ph15121542 crossref_primary_10_1080_15321819_2022_2163178 crossref_primary_10_1016_j_coviro_2017_03_019 crossref_primary_10_1016_j_genrep_2019_100548 crossref_primary_10_1080_07391102_2020_1830852 crossref_primary_10_1038_s41594_020_0427_3 crossref_primary_10_1186_s12944_016_0400_7 crossref_primary_10_1007_s12325_016_0305_x crossref_primary_10_1186_s12879_023_08524_1 crossref_primary_10_3389_fvets_2023_1248445 crossref_primary_10_1016_S2468_1253_18_30308_X crossref_primary_10_3748_wjg_v24_i19_2095 crossref_primary_10_1128_spectrum_01439_25 crossref_primary_10_1128_jvi_00424_24 crossref_primary_10_3389_fmed_2022_890339 crossref_primary_10_1177_1176934319861337 crossref_primary_10_3390_v15112186 crossref_primary_10_1128_AAC_01463_20 crossref_primary_10_7759_cureus_19152 crossref_primary_10_1016_j_bjid_2024_104468 crossref_primary_10_1080_14737159_2022_2076595 crossref_primary_10_5493_wjem_v15_i2_102395 crossref_primary_10_3390_v15122302 crossref_primary_10_1093_infdis_jiw049 crossref_primary_10_1186_s11658_023_00440_1 crossref_primary_10_4103_npmj_npmj_19_22 crossref_primary_10_7705_biomedica_v36i0_2976 crossref_primary_10_3904_kjim_2016_180 crossref_primary_10_1016_j_virol_2025_110692 crossref_primary_10_3390_pathogens13010060 crossref_primary_10_1186_s12879_022_07528_7 crossref_primary_10_1111_jvh_13052 crossref_primary_10_3390_v13061167 crossref_primary_10_3748_wjg_v24_i16_1708 crossref_primary_10_3390_v15010150 crossref_primary_10_1371_journal_pone_0215011 crossref_primary_10_3389_fmicb_2023_1137084 crossref_primary_10_1038_s41598_024_77362_1 crossref_primary_10_1016_j_bjid_2015_03_007 crossref_primary_10_1038_nrdp_2018_35 crossref_primary_10_1016_j_eujim_2018_05_009 crossref_primary_10_3390_genes9090453 crossref_primary_10_1002_iid3_1182 crossref_primary_10_3390_cancers16040777 crossref_primary_10_3390_vaccines9070754 crossref_primary_10_1155_2020_7027169 crossref_primary_10_1186_s12879_020_05229_7 crossref_primary_10_1016_j_compbiomed_2025_110811 crossref_primary_10_1371_journal_pone_0237252 crossref_primary_10_1007_s00535_015_1128_2 crossref_primary_10_1016_j_omtn_2018_02_005 crossref_primary_10_1371_journal_pntd_0012262 crossref_primary_10_3390_microorganisms9081787 crossref_primary_10_1016_j_jcv_2017_12_009 crossref_primary_10_3389_fmicb_2021_687785 crossref_primary_10_3390_ijms22020479 crossref_primary_10_2147_JBM_S314556 crossref_primary_10_1016_j_clinre_2023_102180 crossref_primary_10_1186_s12879_017_2697_x crossref_primary_10_3390_microorganisms11071739 crossref_primary_10_1186_s12985_025_02829_0 crossref_primary_10_1186_s12887_025_05569_w crossref_primary_10_3389_fmicb_2022_946703 crossref_primary_10_1002_jmv_24368 crossref_primary_10_1002_hep_28378 crossref_primary_10_1371_journal_pone_0218744 crossref_primary_10_1097_MD_0000000000018319 crossref_primary_10_1097_MEG_0000000000001381 crossref_primary_10_1016_j_vaccine_2017_07_082 crossref_primary_10_1111_jvh_13889 crossref_primary_10_1002_cld_729 crossref_primary_10_1002_jmv_25346 crossref_primary_10_1111_jvh_13525 crossref_primary_10_1016_j_biologicals_2019_01_003 crossref_primary_10_1016_j_ijmmb_2021_01_002 crossref_primary_10_3748_wjg_v29_i11_1721 crossref_primary_10_1016_j_jbc_2022_101698 crossref_primary_10_3390_diagnostics13030368 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.3748/wjg.v20.i18.5427 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| EISSN | 2219-2840 |
| ExternalDocumentID | 24833873 |
| Genre | Journal Article Review |
| GroupedDBID | --- 123 29R 2WC 36B 53G 5VR 8WL AAKDD ACGFO AENEX AFUIB ALMA_UNASSIGNED_HOLDINGS CCEZO CGR CHBEP CIEJG CS3 CUY CVF CW9 DIK DU5 E3Z EBS ECM EIF EJD F5P FRP GX1 HYE NPM OK1 P2P RNS RPM TR2 XSB 7X8 |
| ID | FETCH-LOGICAL-c440t-e307e790bf96e96b111bfb1e746e35e8c3d0b6da08d75b8c6194b80a631d2d3c2 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 299 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000336048100027&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 2219-2840 |
| IngestDate | Fri Jul 11 11:29:22 EDT 2025 Mon Jul 21 06:04:04 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | true |
| Issue | 18 |
| Keywords | Hepatitis B virus Viral mutation Anti-viral therapy Chronic hepatitis B Genotypes |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c440t-e307e790bf96e96b111bfb1e746e35e8c3d0b6da08d75b8c6194b80a631d2d3c2 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| OpenAccessLink | https://www.wjgnet.com/1007-9327/full/v20/i18/5427.htm |
| PMID | 24833873 |
| PQID | 1539469330 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_1539469330 pubmed_primary_24833873 |
| PublicationCentury | 2000 |
| PublicationDate | 2014-05-14 |
| PublicationDateYYYYMMDD | 2014-05-14 |
| PublicationDate_xml | – month: 05 year: 2014 text: 2014-05-14 day: 14 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | World journal of gastroenterology : WJG |
| PublicationTitleAlternate | World J Gastroenterol |
| PublicationYear | 2014 |
| References | 21199523 - J Gastroenterol Hepatol. 2011 Jan;26 Suppl 1:123-30 23740667 - Int J Cancer. 2013 Dec 15;133(12):2864-71 12076712 - Hepatol Res. 2002 Jul;23(3):167-177 23305043 - Aliment Pharmacol Ther. 2013 Mar;37(5):517-26 15779048 - J Med Virol. 2005 May;76(1):33-9 10702206 - Gastroenterology. 2000 Mar;118(3):554-9 12100608 - J Gastroenterol Hepatol. 2002 Jun;17(6):643-50 23252849 - Microbiol Immunol. 2013 Feb;57(2):122-9 23336976 - Virol J. 2013;10:27 23501362 - Virus Res. 2013 Jun;174(1-2):18-26 23346148 - Hepat Mon. 2012 Nov;12(11):e6191 23183198 - Jpn J Infect Dis. 2012;65(6):476-82 15565403 - J Gastroenterol. 2004 Sep;39(9):844-50 23765773 - J Med Virol. 2013 Aug;85(8):1340-7 15800989 - World J Gastroenterol. 2005 Apr 7;11(13):1976-80 23749665 - Semin Liver Dis. 2013 May;33(2):97-102 17206751 - World J Gastroenterol. 2007 Jan 7;13(1):14-21 11257194 - J Gen Virol. 2001 Apr;82(Pt 4):883-92 23763288 - Liver Int. 2013 Oct;33(9):1363-9 23432545 - J Gastroenterol Hepatol. 2013 Jul;28(7):1234-41 12210405 - J Med Virol. 2002 Oct;68(2):175-81 22827722 - Clin Microbiol Infect. 2012 Oct;18(10):E412-8 22608364 - J Clin Virol. 2012 Aug;54(4):321-6 22473858 - Hepatology. 2013 Mar;57(3):890-6 23123214 - Virus Res. 2013 Jan;171(1):65-70 18505172 - Antivir Ther. 2008;13(2):211-20 23696925 - Int J Clin Exp Pathol. 2013;6(6):1076-85 15720535 - J Viral Hepat. 2005 Mar;12(2):192-8 22783345 - Hepat Mon. 2012 May;12(5):333-8 22016585 - Korean J Intern Med. 2011 Sep;26(3):255-61 23538336 - Infect Genet Evol. 2013 Jun;16:355-61 15578511 - Gastroenterology. 2004 Dec;127(6):1733-8 12753143 - J Gastroenterol Hepatol. 2003 Jun;18(6):630-7 23490378 - J Viral Hepat. 2013 Apr;20(4):e11-9 22579480 - Infect Genet Evol. 2012 Aug;12(6):1157-62 23304671 - Iran J Public Health. 2012;41(11):10-8 23585765 - Hepat Mon. 2013 Jan 20;13(1):e6221 16760389 - J Gen Virol. 2006 Jul;87(Pt 7):1873-82 18755887 - Gut. 2008 Dec;57(12):1713-20 22990965 - Mem Inst Oswaldo Cruz. 2012 Sep;107(6):785-9 22337297 - J Med Virol. 2012 Apr;84(4):587-95 23490376 - J Viral Hepat. 2013 Apr;20(4):e1-2 21375760 - Virol J. 2011;8:102 23383660 - J Viral Hepat. 2013 Mar;20(3):209-18 22859496 - Gut. 2013 Feb;62(2):290-8 23490386 - J Viral Hepat. 2013 Apr;20(4):e27-36 23113154 - Iran J Public Health. 2012;41(3):104-11 17063518 - J Med Virol. 2006 Dec;78(12):1688-95 16461229 - J Clin Virol. 2005 Dec;34 Suppl 1:S79-82 16831687 - J Clin Virol. 2006 May;36 Suppl 1:S12-7 23268113 - Infect Genet Evol. 2013 Mar;14:195-9 23800310 - BMC Infect Dis. 2013;13:286 18771045 - Antivir Ther. 2008;13(5):613-24 22978460 - Hepatol Res. 2013 Apr;43(4):355-64 16343058 - Liver Int. 2005 Dec;25(6):1097-107 21296172 - Mol Phylogenet Evol. 2011 Apr;59(1):114-22 22930500 - J Med Virol. 2012 Oct;84(10):1541-7 23725068 - Arch Iran Med. 2013 Jun;16(6):348-50 23424100 - J Clin Lab Anal. 2013 Mar;27(2):130-6 23071796 - PLoS One. 2012;7(10):e47372 18192693 - Carcinogenesis. 2008 Sep;29(9):1685-91 23771289 - J Infect Dev Ctries. 2013 Jun;7(6):453-67 23349904 - PLoS One. 2013;8(1):e54486 20529201 - J Viral Hepat. 2010 Sep;17(9):601-10 |
| References_xml | – reference: 23538336 - Infect Genet Evol. 2013 Jun;16:355-61 – reference: 23749665 - Semin Liver Dis. 2013 May;33(2):97-102 – reference: 12210405 - J Med Virol. 2002 Oct;68(2):175-81 – reference: 23490376 - J Viral Hepat. 2013 Apr;20(4):e1-2 – reference: 10702206 - Gastroenterology. 2000 Mar;118(3):554-9 – reference: 15800989 - World J Gastroenterol. 2005 Apr 7;11(13):1976-80 – reference: 23305043 - Aliment Pharmacol Ther. 2013 Mar;37(5):517-26 – reference: 22827722 - Clin Microbiol Infect. 2012 Oct;18(10):E412-8 – reference: 23740667 - Int J Cancer. 2013 Dec 15;133(12):2864-71 – reference: 23071796 - PLoS One. 2012;7(10):e47372 – reference: 12100608 - J Gastroenterol Hepatol. 2002 Jun;17(6):643-50 – reference: 12753143 - J Gastroenterol Hepatol. 2003 Jun;18(6):630-7 – reference: 23336976 - Virol J. 2013;10:27 – reference: 23696925 - Int J Clin Exp Pathol. 2013;6(6):1076-85 – reference: 23346148 - Hepat Mon. 2012 Nov;12(11):e6191 – reference: 23424100 - J Clin Lab Anal. 2013 Mar;27(2):130-6 – reference: 18192693 - Carcinogenesis. 2008 Sep;29(9):1685-91 – reference: 23113154 - Iran J Public Health. 2012;41(3):104-11 – reference: 23501362 - Virus Res. 2013 Jun;174(1-2):18-26 – reference: 23765773 - J Med Virol. 2013 Aug;85(8):1340-7 – reference: 22978460 - Hepatol Res. 2013 Apr;43(4):355-64 – reference: 15578511 - Gastroenterology. 2004 Dec;127(6):1733-8 – reference: 21296172 - Mol Phylogenet Evol. 2011 Apr;59(1):114-22 – reference: 17206751 - World J Gastroenterol. 2007 Jan 7;13(1):14-21 – reference: 15779048 - J Med Virol. 2005 May;76(1):33-9 – reference: 12076712 - Hepatol Res. 2002 Jul;23(3):167-177 – reference: 15720535 - J Viral Hepat. 2005 Mar;12(2):192-8 – reference: 23585765 - Hepat Mon. 2013 Jan 20;13(1):e6221 – reference: 22930500 - J Med Virol. 2012 Oct;84(10):1541-7 – reference: 18771045 - Antivir Ther. 2008;13(5):613-24 – reference: 11257194 - J Gen Virol. 2001 Apr;82(Pt 4):883-92 – reference: 18755887 - Gut. 2008 Dec;57(12):1713-20 – reference: 17063518 - J Med Virol. 2006 Dec;78(12):1688-95 – reference: 23800310 - BMC Infect Dis. 2013;13:286 – reference: 22859496 - Gut. 2013 Feb;62(2):290-8 – reference: 23183198 - Jpn J Infect Dis. 2012;65(6):476-82 – reference: 16343058 - Liver Int. 2005 Dec;25(6):1097-107 – reference: 23432545 - J Gastroenterol Hepatol. 2013 Jul;28(7):1234-41 – reference: 22337297 - J Med Virol. 2012 Apr;84(4):587-95 – reference: 21375760 - Virol J. 2011;8:102 – reference: 23383660 - J Viral Hepat. 2013 Mar;20(3):209-18 – reference: 23771289 - J Infect Dev Ctries. 2013 Jun;7(6):453-67 – reference: 22473858 - Hepatology. 2013 Mar;57(3):890-6 – reference: 23490386 - J Viral Hepat. 2013 Apr;20(4):e27-36 – reference: 23725068 - Arch Iran Med. 2013 Jun;16(6):348-50 – reference: 23252849 - Microbiol Immunol. 2013 Feb;57(2):122-9 – reference: 22990965 - Mem Inst Oswaldo Cruz. 2012 Sep;107(6):785-9 – reference: 23349904 - PLoS One. 2013;8(1):e54486 – reference: 23268113 - Infect Genet Evol. 2013 Mar;14:195-9 – reference: 16760389 - J Gen Virol. 2006 Jul;87(Pt 7):1873-82 – reference: 22579480 - Infect Genet Evol. 2012 Aug;12(6):1157-62 – reference: 16461229 - J Clin Virol. 2005 Dec;34 Suppl 1:S79-82 – reference: 23490378 - J Viral Hepat. 2013 Apr;20(4):e11-9 – reference: 22016585 - Korean J Intern Med. 2011 Sep;26(3):255-61 – reference: 16831687 - J Clin Virol. 2006 May;36 Suppl 1:S12-7 – reference: 23763288 - Liver Int. 2013 Oct;33(9):1363-9 – reference: 23123214 - Virus Res. 2013 Jan;171(1):65-70 – reference: 20529201 - J Viral Hepat. 2010 Sep;17(9):601-10 – reference: 22608364 - J Clin Virol. 2012 Aug;54(4):321-6 – reference: 21199523 - J Gastroenterol Hepatol. 2011 Jan;26 Suppl 1:123-30 – reference: 22783345 - Hepat Mon. 2012 May;12(5):333-8 – reference: 23304671 - Iran J Public Health. 2012;41(11):10-8 – reference: 18505172 - Antivir Ther. 2008;13(2):211-20 – reference: 15565403 - J Gastroenterol. 2004 Sep;39(9):844-50 |
| SSID | ssj0023352 |
| Score | 2.5868318 |
| SecondaryResourceType | review_article |
| Snippet | At least 600000 individuals worldwide annually die of hepatitis B virus (HBV)-related diseases, such as chronic hepatitis B (CHB), liver cirrhosis (LC), and... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 5427 |
| SubjectTerms | Antiviral Agents - therapeutic use Biomarkers - blood Drug Resistance, Viral Genotype Global Health Hepatitis B - diagnosis Hepatitis B - drug therapy Hepatitis B - epidemiology Hepatitis B - immunology Hepatitis B - virology Hepatitis B e Antigens - blood Hepatitis B Surface Antigens - blood Hepatitis B virus - drug effects Hepatitis B virus - genetics Hepatitis B virus - immunology Hepatitis B virus - pathogenicity Humans Phenotype Treatment Outcome |
| Title | Hepatitis B virus genotypes: global distribution and clinical importance |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/24833873 https://www.proquest.com/docview/1539469330 |
| Volume | 20 |
| WOSCitedRecordID | wos000336048100027&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV07T8MwELaAMrDwEK_ykpFY3dqOk9gsCBBVB6g6AOoWxY-gVCItTVv-PuckhQkJiSVbpOhyd7677_x9CF0JbjKPbxGulSTCuIykNLREhgrOS8s0r7QBXx_jwUCORmrYDNzKZq1ylROrRG0nxs_IuxCZClo5aL9vph_Eq0Z5dLWR0FhHrQBKGb_SFY--UQTu7xN5cTmISgJpmNYwpSdc6X6O3zpLTjs5k51Q8Pj3ArM6aHo7__3EXbTdlJj4tvaJPbTmin3U7zu_Oz3PS3yHl_lsUWJPz-onsOU1rmlBsPUsuo0AFk4Li1f3JnH-XtXp4CEH6KX38HzfJ42KAjFC0DlxEMUuVlRnKnIq0pDcdKaZi0XkgtBJE1iqI5tSaeNQS-PHGlrSNAqY5TYw_BBtFJPCHSPMXGQlY0ZkJhVBpKSwRjNDFc2YdpK10eXKMAl4qYce0sJNFmXyY5o2Oqqtm0xrOo2ECwl9chyc_OHtU7QFFYvw8D0TZ6iVQYy6c7RplmC_2UX1--E5GD59AUFHurM |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Hepatitis+B+virus+genotypes%3A+global+distribution+and+clinical+importance&rft.jtitle=World+journal+of+gastroenterology+%3A+WJG&rft.au=Sunbul%2C+Mustafa&rft.date=2014-05-14&rft.eissn=2219-2840&rft.volume=20&rft.issue=18&rft.spage=5427&rft_id=info:doi/10.3748%2Fwjg.v20.i18.5427&rft_id=info%3Apmid%2F24833873&rft_id=info%3Apmid%2F24833873&rft.externalDocID=24833873 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2219-2840&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2219-2840&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2219-2840&client=summon |