Hepatitis B virus genotypes: global distribution and clinical importance
At least 600000 individuals worldwide annually die of hepatitis B virus (HBV)-related diseases, such as chronic hepatitis B (CHB), liver cirrhosis (LC), and hepatocellular carcinoma (HCC). Many viral factors, such as viral load, genotype, and specific viral mutations, are known to affect disease pro...
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| Vydáno v: | World journal of gastroenterology : WJG Ročník 20; číslo 18; s. 5427 |
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| Hlavní autor: | |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
United States
14.05.2014
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| Témata: | |
| ISSN: | 2219-2840, 2219-2840 |
| On-line přístup: | Zjistit podrobnosti o přístupu |
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| Abstract | At least 600000 individuals worldwide annually die of hepatitis B virus (HBV)-related diseases, such as chronic hepatitis B (CHB), liver cirrhosis (LC), and hepatocellular carcinoma (HCC). Many viral factors, such as viral load, genotype, and specific viral mutations, are known to affect disease progression. HBV reverse transcriptase does not have a proofreading function, therefore, many HBV genotypes, sub-genotypes, mutants, and recombinants emerge. Differences between genotypes in response to antiviral treatment have been determined. To date, 10 HBV genotypes, scattered across different geographical regions, have been identified. For example, genotype A has a tendency for chronicity, whereas viral mutations are frequently encountered in genotype C. Both chronicity and mutation frequency are common in genotype D. LC and progression to HCC are more commonly encountered with genotypes C and D than the other genotypes. Pathogenic differences between HBV genotypes explain disease intensity, progression to LC, and HCC. In conclusion, genotype determination in CHB infection is important in estimating disease progression and planning optimal antiviral treatment. |
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| AbstractList | At least 600000 individuals worldwide annually die of hepatitis B virus (HBV)-related diseases, such as chronic hepatitis B (CHB), liver cirrhosis (LC), and hepatocellular carcinoma (HCC). Many viral factors, such as viral load, genotype, and specific viral mutations, are known to affect disease progression. HBV reverse transcriptase does not have a proofreading function, therefore, many HBV genotypes, sub-genotypes, mutants, and recombinants emerge. Differences between genotypes in response to antiviral treatment have been determined. To date, 10 HBV genotypes, scattered across different geographical regions, have been identified. For example, genotype A has a tendency for chronicity, whereas viral mutations are frequently encountered in genotype C. Both chronicity and mutation frequency are common in genotype D. LC and progression to HCC are more commonly encountered with genotypes C and D than the other genotypes. Pathogenic differences between HBV genotypes explain disease intensity, progression to LC, and HCC. In conclusion, genotype determination in CHB infection is important in estimating disease progression and planning optimal antiviral treatment. At least 600000 individuals worldwide annually die of hepatitis B virus (HBV)-related diseases, such as chronic hepatitis B (CHB), liver cirrhosis (LC), and hepatocellular carcinoma (HCC). Many viral factors, such as viral load, genotype, and specific viral mutations, are known to affect disease progression. HBV reverse transcriptase does not have a proofreading function, therefore, many HBV genotypes, sub-genotypes, mutants, and recombinants emerge. Differences between genotypes in response to antiviral treatment have been determined. To date, 10 HBV genotypes, scattered across different geographical regions, have been identified. For example, genotype A has a tendency for chronicity, whereas viral mutations are frequently encountered in genotype C. Both chronicity and mutation frequency are common in genotype D. LC and progression to HCC are more commonly encountered with genotypes C and D than the other genotypes. Pathogenic differences between HBV genotypes explain disease intensity, progression to LC, and HCC. In conclusion, genotype determination in CHB infection is important in estimating disease progression and planning optimal antiviral treatment.At least 600000 individuals worldwide annually die of hepatitis B virus (HBV)-related diseases, such as chronic hepatitis B (CHB), liver cirrhosis (LC), and hepatocellular carcinoma (HCC). Many viral factors, such as viral load, genotype, and specific viral mutations, are known to affect disease progression. HBV reverse transcriptase does not have a proofreading function, therefore, many HBV genotypes, sub-genotypes, mutants, and recombinants emerge. Differences between genotypes in response to antiviral treatment have been determined. To date, 10 HBV genotypes, scattered across different geographical regions, have been identified. For example, genotype A has a tendency for chronicity, whereas viral mutations are frequently encountered in genotype C. Both chronicity and mutation frequency are common in genotype D. LC and progression to HCC are more commonly encountered with genotypes C and D than the other genotypes. Pathogenic differences between HBV genotypes explain disease intensity, progression to LC, and HCC. In conclusion, genotype determination in CHB infection is important in estimating disease progression and planning optimal antiviral treatment. |
| Author | Sunbul, Mustafa |
| Author_xml | – sequence: 1 givenname: Mustafa surname: Sunbul fullname: Sunbul, Mustafa organization: Mustafa Sunbul, Department of Infectious Diseases, School of Medicine, Ondokuz Mayis University, 55139 Samsun, Turkey |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24833873$$D View this record in MEDLINE/PubMed |
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| Keywords | Hepatitis B virus Viral mutation Anti-viral therapy Chronic hepatitis B Genotypes |
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| PublicationYear | 2014 |
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| References_xml | – reference: 23538336 - Infect Genet Evol. 2013 Jun;16:355-61 – reference: 23749665 - Semin Liver Dis. 2013 May;33(2):97-102 – reference: 12210405 - J Med Virol. 2002 Oct;68(2):175-81 – reference: 23490376 - J Viral Hepat. 2013 Apr;20(4):e1-2 – reference: 10702206 - Gastroenterology. 2000 Mar;118(3):554-9 – reference: 15800989 - World J Gastroenterol. 2005 Apr 7;11(13):1976-80 – reference: 23305043 - Aliment Pharmacol Ther. 2013 Mar;37(5):517-26 – reference: 22827722 - Clin Microbiol Infect. 2012 Oct;18(10):E412-8 – reference: 23740667 - Int J Cancer. 2013 Dec 15;133(12):2864-71 – reference: 23071796 - PLoS One. 2012;7(10):e47372 – reference: 12100608 - J Gastroenterol Hepatol. 2002 Jun;17(6):643-50 – reference: 12753143 - J Gastroenterol Hepatol. 2003 Jun;18(6):630-7 – reference: 23336976 - Virol J. 2013;10:27 – reference: 23696925 - Int J Clin Exp Pathol. 2013;6(6):1076-85 – reference: 23346148 - Hepat Mon. 2012 Nov;12(11):e6191 – reference: 23424100 - J Clin Lab Anal. 2013 Mar;27(2):130-6 – reference: 18192693 - Carcinogenesis. 2008 Sep;29(9):1685-91 – reference: 23113154 - Iran J Public Health. 2012;41(3):104-11 – reference: 23501362 - Virus Res. 2013 Jun;174(1-2):18-26 – reference: 23765773 - J Med Virol. 2013 Aug;85(8):1340-7 – reference: 22978460 - Hepatol Res. 2013 Apr;43(4):355-64 – reference: 15578511 - Gastroenterology. 2004 Dec;127(6):1733-8 – reference: 21296172 - Mol Phylogenet Evol. 2011 Apr;59(1):114-22 – reference: 17206751 - World J Gastroenterol. 2007 Jan 7;13(1):14-21 – reference: 15779048 - J Med Virol. 2005 May;76(1):33-9 – reference: 12076712 - Hepatol Res. 2002 Jul;23(3):167-177 – reference: 15720535 - J Viral Hepat. 2005 Mar;12(2):192-8 – reference: 23585765 - Hepat Mon. 2013 Jan 20;13(1):e6221 – reference: 22930500 - J Med Virol. 2012 Oct;84(10):1541-7 – reference: 18771045 - Antivir Ther. 2008;13(5):613-24 – reference: 11257194 - J Gen Virol. 2001 Apr;82(Pt 4):883-92 – reference: 18755887 - Gut. 2008 Dec;57(12):1713-20 – reference: 17063518 - J Med Virol. 2006 Dec;78(12):1688-95 – reference: 23800310 - BMC Infect Dis. 2013;13:286 – reference: 22859496 - Gut. 2013 Feb;62(2):290-8 – reference: 23183198 - Jpn J Infect Dis. 2012;65(6):476-82 – reference: 16343058 - Liver Int. 2005 Dec;25(6):1097-107 – reference: 23432545 - J Gastroenterol Hepatol. 2013 Jul;28(7):1234-41 – reference: 22337297 - J Med Virol. 2012 Apr;84(4):587-95 – reference: 21375760 - Virol J. 2011;8:102 – reference: 23383660 - J Viral Hepat. 2013 Mar;20(3):209-18 – reference: 23771289 - J Infect Dev Ctries. 2013 Jun;7(6):453-67 – reference: 22473858 - Hepatology. 2013 Mar;57(3):890-6 – reference: 23490386 - J Viral Hepat. 2013 Apr;20(4):e27-36 – reference: 23725068 - Arch Iran Med. 2013 Jun;16(6):348-50 – reference: 23252849 - Microbiol Immunol. 2013 Feb;57(2):122-9 – reference: 22990965 - Mem Inst Oswaldo Cruz. 2012 Sep;107(6):785-9 – reference: 23349904 - PLoS One. 2013;8(1):e54486 – reference: 23268113 - Infect Genet Evol. 2013 Mar;14:195-9 – reference: 16760389 - J Gen Virol. 2006 Jul;87(Pt 7):1873-82 – reference: 22579480 - Infect Genet Evol. 2012 Aug;12(6):1157-62 – reference: 16461229 - J Clin Virol. 2005 Dec;34 Suppl 1:S79-82 – reference: 23490378 - J Viral Hepat. 2013 Apr;20(4):e11-9 – reference: 22016585 - Korean J Intern Med. 2011 Sep;26(3):255-61 – reference: 16831687 - J Clin Virol. 2006 May;36 Suppl 1:S12-7 – reference: 23763288 - Liver Int. 2013 Oct;33(9):1363-9 – reference: 23123214 - Virus Res. 2013 Jan;171(1):65-70 – reference: 20529201 - J Viral Hepat. 2010 Sep;17(9):601-10 – reference: 22608364 - J Clin Virol. 2012 Aug;54(4):321-6 – reference: 21199523 - J Gastroenterol Hepatol. 2011 Jan;26 Suppl 1:123-30 – reference: 22783345 - Hepat Mon. 2012 May;12(5):333-8 – reference: 23304671 - Iran J Public Health. 2012;41(11):10-8 – reference: 18505172 - Antivir Ther. 2008;13(2):211-20 – reference: 15565403 - J Gastroenterol. 2004 Sep;39(9):844-50 |
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| Snippet | At least 600000 individuals worldwide annually die of hepatitis B virus (HBV)-related diseases, such as chronic hepatitis B (CHB), liver cirrhosis (LC), and... |
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| SubjectTerms | Antiviral Agents - therapeutic use Biomarkers - blood Drug Resistance, Viral Genotype Global Health Hepatitis B - diagnosis Hepatitis B - drug therapy Hepatitis B - epidemiology Hepatitis B - immunology Hepatitis B - virology Hepatitis B e Antigens - blood Hepatitis B Surface Antigens - blood Hepatitis B virus - drug effects Hepatitis B virus - genetics Hepatitis B virus - immunology Hepatitis B virus - pathogenicity Humans Phenotype Treatment Outcome |
| Title | Hepatitis B virus genotypes: global distribution and clinical importance |
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