A genome-wide association study identifies nucleotide variants at SIGLEC5 and DEFA1A3 as risk loci for periodontitis

Periodontitis is one of the most common inflammatory diseases, with a prevalence of 11% worldwide for the severe forms and an estimated heritability of 50%. The disease is characterized by destruction of the alveolar bone due to an aberrant host inflammatory response to a dysbiotic oral microbiome....

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Veröffentlicht in:	Human molecular genetics Jg. 26; H. 13; S. 2577
Hauptverfasser:	Munz, Matthias, Willenborg, Christina, Richter, Gesa M, Jockel-Schneider, Yvonne, Graetz, Christian, Staufenbiel, Ingmar, Wellmann, Jürgen, Berger, Klaus, Krone, Bastian, Hoffmann, Per, van der Velde, Nathalie, Uitterlinden, André G, de Groot, Lisette C P G M, Sawalha, Amr H, Direskeneli, Haner, Saruhan-Direskeneli, Güher, Guzeldemir-Akcakanat, Esra, Keceli, Huseyin Gencay, Laudes, Matthias, Noack, Barbara, Teumer, Alexander, Holtfreter, Birte, Kocher, Thomas, Eickholz, Peter, Meyle, Jörg, Doerfer, Christof, Bruckmann, Corinna, Lieb, Wolfgang, Franke, Andre, Schreiber, Stefan, Nohutcu, Rahime M, Erdmann, Jeanette, Loos, Bruno G, Jepsen, Soeren, Dommisch, Henrik, Schaefer, Arne S
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England 01.07.2017
Schlagworte:	Adult Aggressive Periodontitis - genetics alpha-Defensins - genetics alpha-Defensins - metabolism Antigens, CD - genetics Antigens, CD - metabolism Antigens, Differentiation, Myelomonocytic - genetics Antigens, Differentiation, Myelomonocytic - metabolism Case-Control Studies Chronic Periodontitis - genetics Female Genetic Loci Genetic Predisposition to Disease Genome-Wide Association Study Genotype Humans Lectins - genetics Lectins - metabolism Male Middle Aged Nucleotides Peptides, Cyclic - genetics Peptides, Cyclic - metabolism Phenotype Polymorphism, Single Nucleotide - genetics Risk Factors Turkey
ISSN:	1460-2083, 1460-2083
Online-Zugang:	Weitere Angaben
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