A genome-wide association study identifies nucleotide variants at SIGLEC5 and DEFA1A3 as risk loci for periodontitis
Periodontitis is one of the most common inflammatory diseases, with a prevalence of 11% worldwide for the severe forms and an estimated heritability of 50%. The disease is characterized by destruction of the alveolar bone due to an aberrant host inflammatory response to a dysbiotic oral microbiome....
Uloženo v:
| Vydáno v: | Human molecular genetics Ročník 26; číslo 13; s. 2577 |
|---|---|
| Hlavní autoři: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
England
01.07.2017
|
| Témata: | |
| ISSN: | 1460-2083, 1460-2083 |
| On-line přístup: | Zjistit podrobnosti o přístupu |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Periodontitis is one of the most common inflammatory diseases, with a prevalence of 11% worldwide for the severe forms and an estimated heritability of 50%. The disease is characterized by destruction of the alveolar bone due to an aberrant host inflammatory response to a dysbiotic oral microbiome. Previous genome-wide association studies (GWAS) have reported several suggestive susceptibility loci. Here, we conducted a GWAS using a German and Dutch case-control sample of aggressive periodontitis (AgP, 896 cases, 7,104 controls), a rare but highly severe and early-onset form of periodontitis, validated the associations in a German sample of severe forms of the more moderate phenotype chronic periodontitis (CP) (993 cases, 1,419 controls). Positive findings were replicated in a Turkish sample of AgP (223 cases, 564 controls). A locus at SIGLEC5 (sialic acid binding Ig-like lectin 5) and a chromosomal region downstream of the DEFA1A3 locus (defensin alpha 1-3) showed association with both disease phenotypes and were associated with periodontitis at a genome-wide significance level in the pooled samples, with P = 1.09E-08 (rs4284742,-G; OR = 1.34, 95% CI = 1.21-1.48) and P = 5.48E-10 (rs2738058,-T; OR = 1.28, 95% CI = 1.18-1.38), respectively. SIGLEC5 is expressed in various myeloid immune cells and classified as an inhibitory receptor with the potential to mediate tyrosine phosphatases SHP-1/-2 dependent signaling. Alpha defensins are antimicrobial peptides with expression in neutrophils and mucosal surfaces and a role in phagocyte-mediated host defense. This study identifies the first shared genetic risk loci of AgP and CP with genome-wide significance and highlights the role of innate and adaptive immunity in the etiology of periodontitis. |
|---|---|
| AbstractList | Periodontitis is one of the most common inflammatory diseases, with a prevalence of 11% worldwide for the severe forms and an estimated heritability of 50%. The disease is characterized by destruction of the alveolar bone due to an aberrant host inflammatory response to a dysbiotic oral microbiome. Previous genome-wide association studies (GWAS) have reported several suggestive susceptibility loci. Here, we conducted a GWAS using a German and Dutch case-control sample of aggressive periodontitis (AgP, 896 cases, 7,104 controls), a rare but highly severe and early-onset form of periodontitis, validated the associations in a German sample of severe forms of the more moderate phenotype chronic periodontitis (CP) (993 cases, 1,419 controls). Positive findings were replicated in a Turkish sample of AgP (223 cases, 564 controls). A locus at SIGLEC5 (sialic acid binding Ig-like lectin 5) and a chromosomal region downstream of the DEFA1A3 locus (defensin alpha 1-3) showed association with both disease phenotypes and were associated with periodontitis at a genome-wide significance level in the pooled samples, with P = 1.09E-08 (rs4284742,-G; OR = 1.34, 95% CI = 1.21-1.48) and P = 5.48E-10 (rs2738058,-T; OR = 1.28, 95% CI = 1.18-1.38), respectively. SIGLEC5 is expressed in various myeloid immune cells and classified as an inhibitory receptor with the potential to mediate tyrosine phosphatases SHP-1/-2 dependent signaling. Alpha defensins are antimicrobial peptides with expression in neutrophils and mucosal surfaces and a role in phagocyte-mediated host defense. This study identifies the first shared genetic risk loci of AgP and CP with genome-wide significance and highlights the role of innate and adaptive immunity in the etiology of periodontitis.Periodontitis is one of the most common inflammatory diseases, with a prevalence of 11% worldwide for the severe forms and an estimated heritability of 50%. The disease is characterized by destruction of the alveolar bone due to an aberrant host inflammatory response to a dysbiotic oral microbiome. Previous genome-wide association studies (GWAS) have reported several suggestive susceptibility loci. Here, we conducted a GWAS using a German and Dutch case-control sample of aggressive periodontitis (AgP, 896 cases, 7,104 controls), a rare but highly severe and early-onset form of periodontitis, validated the associations in a German sample of severe forms of the more moderate phenotype chronic periodontitis (CP) (993 cases, 1,419 controls). Positive findings were replicated in a Turkish sample of AgP (223 cases, 564 controls). A locus at SIGLEC5 (sialic acid binding Ig-like lectin 5) and a chromosomal region downstream of the DEFA1A3 locus (defensin alpha 1-3) showed association with both disease phenotypes and were associated with periodontitis at a genome-wide significance level in the pooled samples, with P = 1.09E-08 (rs4284742,-G; OR = 1.34, 95% CI = 1.21-1.48) and P = 5.48E-10 (rs2738058,-T; OR = 1.28, 95% CI = 1.18-1.38), respectively. SIGLEC5 is expressed in various myeloid immune cells and classified as an inhibitory receptor with the potential to mediate tyrosine phosphatases SHP-1/-2 dependent signaling. Alpha defensins are antimicrobial peptides with expression in neutrophils and mucosal surfaces and a role in phagocyte-mediated host defense. This study identifies the first shared genetic risk loci of AgP and CP with genome-wide significance and highlights the role of innate and adaptive immunity in the etiology of periodontitis. Periodontitis is one of the most common inflammatory diseases, with a prevalence of 11% worldwide for the severe forms and an estimated heritability of 50%. The disease is characterized by destruction of the alveolar bone due to an aberrant host inflammatory response to a dysbiotic oral microbiome. Previous genome-wide association studies (GWAS) have reported several suggestive susceptibility loci. Here, we conducted a GWAS using a German and Dutch case-control sample of aggressive periodontitis (AgP, 896 cases, 7,104 controls), a rare but highly severe and early-onset form of periodontitis, validated the associations in a German sample of severe forms of the more moderate phenotype chronic periodontitis (CP) (993 cases, 1,419 controls). Positive findings were replicated in a Turkish sample of AgP (223 cases, 564 controls). A locus at SIGLEC5 (sialic acid binding Ig-like lectin 5) and a chromosomal region downstream of the DEFA1A3 locus (defensin alpha 1-3) showed association with both disease phenotypes and were associated with periodontitis at a genome-wide significance level in the pooled samples, with P = 1.09E-08 (rs4284742,-G; OR = 1.34, 95% CI = 1.21-1.48) and P = 5.48E-10 (rs2738058,-T; OR = 1.28, 95% CI = 1.18-1.38), respectively. SIGLEC5 is expressed in various myeloid immune cells and classified as an inhibitory receptor with the potential to mediate tyrosine phosphatases SHP-1/-2 dependent signaling. Alpha defensins are antimicrobial peptides with expression in neutrophils and mucosal surfaces and a role in phagocyte-mediated host defense. This study identifies the first shared genetic risk loci of AgP and CP with genome-wide significance and highlights the role of innate and adaptive immunity in the etiology of periodontitis. |
| Author | Richter, Gesa M van der Velde, Nathalie Jepsen, Soeren Uitterlinden, André G Graetz, Christian Schaefer, Arne S Berger, Klaus Direskeneli, Haner Dommisch, Henrik Wellmann, Jürgen Laudes, Matthias Schreiber, Stefan Nohutcu, Rahime M Sawalha, Amr H Loos, Bruno G Bruckmann, Corinna Saruhan-Direskeneli, Güher Erdmann, Jeanette de Groot, Lisette C P G M Doerfer, Christof Holtfreter, Birte Meyle, Jörg Guzeldemir-Akcakanat, Esra Keceli, Huseyin Gencay Franke, Andre Lieb, Wolfgang Eickholz, Peter Krone, Bastian Jockel-Schneider, Yvonne Noack, Barbara Teumer, Alexander Staufenbiel, Ingmar Kocher, Thomas Hoffmann, Per Willenborg, Christina Munz, Matthias |
| Author_xml | – sequence: 1 givenname: Matthias surname: Munz fullname: Munz, Matthias organization: Institute for Integrative and Experimental Genomics, University Medical Center Schleswig-Holstein - Campus Lübeck, Germany – sequence: 2 givenname: Christina surname: Willenborg fullname: Willenborg, Christina organization: Institute for Integrative and Experimental Genomics, University Medical Center Schleswig-Holstein - Campus Lübeck, Germany – sequence: 3 givenname: Gesa M surname: Richter fullname: Richter, Gesa M organization: Department of Periodontology and Synoptic Dentistry, Institute of Dental, Oral and Maxillary Medicine, Charité - University Medicine Berlin, Germany – sequence: 4 givenname: Yvonne surname: Jockel-Schneider fullname: Jockel-Schneider, Yvonne organization: Department of Periodontology, Clinic of Preventive Dentistry and Periodontology, University Medical Center of the Julius-Maximilians-University, Würzburg, Germany – sequence: 5 givenname: Christian surname: Graetz fullname: Graetz, Christian organization: Department of Operative Dentistry and Periodontology, University Medical Center Schleswig-Holstein, Campus Kiel, Germany – sequence: 6 givenname: Ingmar surname: Staufenbiel fullname: Staufenbiel, Ingmar organization: Department of Conservative Dentistry, Periodontology and Preventive Dentistry, Hannover Medical School, Hannover, Germany – sequence: 7 givenname: Jürgen surname: Wellmann fullname: Wellmann, Jürgen organization: Institute of Epidemiology and Social Medicine, University Münster, Germany – sequence: 8 givenname: Klaus surname: Berger fullname: Berger, Klaus organization: Institute of Epidemiology and Social Medicine, University Münster, Germany – sequence: 9 givenname: Bastian surname: Krone fullname: Krone, Bastian organization: Institute of Medical Informatics, Biometry and Epidemiology, University Clinic Essen, Germany – sequence: 10 givenname: Per surname: Hoffmann fullname: Hoffmann, Per organization: Human Genomics Research Group, Department of Biomedicine, University Hospital of Basel, Switzerland – sequence: 11 givenname: Nathalie surname: van der Velde fullname: van der Velde, Nathalie organization: Department of Internal Medicine Section of Geriatrics, Amsterdam Medical Center, Amsterdam, The Netherlands – sequence: 12 givenname: André G surname: Uitterlinden fullname: Uitterlinden, André G organization: Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands – sequence: 13 givenname: Lisette C P G M surname: de Groot fullname: de Groot, Lisette C P G M organization: Department of Epidemiology and the EMGO Institute of Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands – sequence: 14 givenname: Amr H surname: Sawalha fullname: Sawalha, Amr H organization: Center for Computational Medicine and Bioinformatics, University of Michigan Medical School, USA – sequence: 15 givenname: Haner surname: Direskeneli fullname: Direskeneli, Haner organization: Division of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey – sequence: 16 givenname: Güher surname: Saruhan-Direskeneli fullname: Saruhan-Direskeneli, Güher organization: Department of Physiology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey – sequence: 17 givenname: Esra surname: Guzeldemir-Akcakanat fullname: Guzeldemir-Akcakanat, Esra organization: Department of Periodontology, Faculty of Dentistry, Kocaeli University, Turkey – sequence: 18 givenname: Huseyin Gencay surname: Keceli fullname: Keceli, Huseyin Gencay organization: Department of Periodontology, Faculty of Dentistry, Hacettepe University, Sihhiye, Ankara, Turkey – sequence: 19 givenname: Matthias surname: Laudes fullname: Laudes, Matthias organization: Clinic of Internal Medicine, University Clinic Schleswig-Holstein, Kiel, Germany – sequence: 20 givenname: Barbara surname: Noack fullname: Noack, Barbara organization: Clinic of Conservational Dentistry, Center of Dental, Oral and Maxillary Medicine, University Medical Center Carl-Gustav-Carus, Technical University Dresden, Germany – sequence: 21 givenname: Alexander surname: Teumer fullname: Teumer, Alexander organization: Institute for Community Medicine, University Medicine Greifswald, Germany – sequence: 22 givenname: Birte surname: Holtfreter fullname: Holtfreter, Birte organization: Unit of Periodontology, Department of Restorative Dentistry, Periodontology, Endodontology, Preventive Dentistry and Pedodontics, Dental School, University Medicine Greifswald, Germany – sequence: 23 givenname: Thomas surname: Kocher fullname: Kocher, Thomas organization: Unit of Periodontology, Department of Restorative Dentistry, Periodontology, Endodontology, Preventive Dentistry and Pedodontics, Dental School, University Medicine Greifswald, Germany – sequence: 24 givenname: Peter surname: Eickholz fullname: Eickholz, Peter organization: Department of Periodontology, Johann Wolfgang Goethe-University, Frankfurt am Main, Germany – sequence: 25 givenname: Jörg surname: Meyle fullname: Meyle, Jörg organization: Department of Periodontology, University Medical Center Giessen and Marburg, Germany – sequence: 26 givenname: Christof surname: Doerfer fullname: Doerfer, Christof organization: Department of Operative Dentistry and Periodontology, University Medical Center Schleswig-Holstein, Campus Kiel, Germany – sequence: 27 givenname: Corinna surname: Bruckmann fullname: Bruckmann, Corinna organization: Department of Conservative Dentistry and Periodontology, Medical University Vienna, School of Dentistry, Vienna, Austria – sequence: 28 givenname: Wolfgang surname: Lieb fullname: Lieb, Wolfgang organization: Institute of Epidemiology, Biobank PopGen, Christian-Albrechts-University, Kiel, Germany – sequence: 29 givenname: Andre surname: Franke fullname: Franke, Andre organization: Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany – sequence: 30 givenname: Stefan surname: Schreiber fullname: Schreiber, Stefan organization: Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany – sequence: 31 givenname: Rahime M surname: Nohutcu fullname: Nohutcu, Rahime M organization: Department of Periodontology, Faculty of Dentistry, Kocaeli University, Turkey – sequence: 32 givenname: Jeanette surname: Erdmann fullname: Erdmann, Jeanette organization: Institute for Integrative and Experimental Genomics, University Medical Center Schleswig-Holstein - Campus Lübeck, Germany – sequence: 33 givenname: Bruno G surname: Loos fullname: Loos, Bruno G organization: Department of Periodontology and Oral Biochemistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, The Netherlands – sequence: 34 givenname: Soeren surname: Jepsen fullname: Jepsen, Soeren organization: Department of Periodontology, Operative and Preventive Dentistry, University of Bonn, Bonn, Germany – sequence: 35 givenname: Henrik surname: Dommisch fullname: Dommisch, Henrik organization: Department of Periodontology and Synoptic Dentistry, Institute of Dental, Oral and Maxillary Medicine, Charité - University Medicine Berlin, Germany – sequence: 36 givenname: Arne S surname: Schaefer fullname: Schaefer, Arne S organization: Department of Periodontology and Synoptic Dentistry, Institute of Dental, Oral and Maxillary Medicine, Charité - University Medicine Berlin, Germany |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28449029$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNkDtPwzAYRS1UREth4QcgjyyhfuXhsSptqVSJAZgjx_5SDIldYgfovyeIIjHdq6ujM9xzNHLeAUJXlNxSIvnspd3NjPmiKT1BEyoykjBS8NG_PkbnIbwSQjPB8zM0ZoUQkjA5QXGOd-B8C8mnNYBVCF5bFa13OMTeHPCwumhrCwG7Xjfg4w_3oTqrXAxYRfy4WW-XixQrZ_DdcjWncz54cGfDG24GG659h_fQWW_8oIo2XKDTWjUBLo85Rc-r5dPiPtk-rDeL-TbRQpCYGK2ynBZ5RQRRFRChmCzqrNIVTzmDKtcUOGRM5lpTI1UOitYpaMZTYBQUm6KbX---8-89hFi2NmhoGuXA96GkheRpyiQvBvT6iPZVC6bcd7ZV3aH8e4p9A8XlbQ0 |
| CitedBy_id | crossref_primary_10_1111_jcpe_13922 crossref_primary_10_1038_s41467_018_05940_9 crossref_primary_10_1186_s40168_025_02087_w crossref_primary_10_3389_fendo_2024_1271351 crossref_primary_10_1016_j_archoralbio_2018_04_012 crossref_primary_10_1111_jcpe_13045 crossref_primary_10_3390_cells12010070 crossref_primary_10_1111_jcpe_13087 crossref_primary_10_1155_2019_2907062 crossref_primary_10_1002_brb3_2888 crossref_primary_10_1016_j_sjbs_2021_04_028 crossref_primary_10_3389_fgene_2021_767577 crossref_primary_10_1371_journal_pone_0275199 crossref_primary_10_1002_JPER_20_0096 crossref_primary_10_1080_08820139_2020_1841222 crossref_primary_10_1177_00220345211049984 crossref_primary_10_3390_ph17060766 crossref_primary_10_1016_j_genrep_2020_100814 crossref_primary_10_1111_jcpe_12879 crossref_primary_10_1111_jcpe_13605 crossref_primary_10_1016_j_identj_2024_05_004 crossref_primary_10_1111_jcpe_13538 crossref_primary_10_1111_jre_13057 crossref_primary_10_3390_pharmaceutics14081679 crossref_primary_10_1093_hmg_ddab085 crossref_primary_10_1111_jcpe_13852 crossref_primary_10_1002_jcp_29005 crossref_primary_10_1016_j_atherosclerosis_2020_09_029 crossref_primary_10_1093_eurheartj_ehaf049 crossref_primary_10_1155_2019_4029217 crossref_primary_10_3390_ijms21113829 crossref_primary_10_3390_cells13020117 crossref_primary_10_1111_jre_13411 crossref_primary_10_1111_prd_12297 crossref_primary_10_1002_jbmr_3440 crossref_primary_10_1177_0022034519877387 crossref_primary_10_26599_OSHM_2025_9610031 crossref_primary_10_1111_jre_70002 crossref_primary_10_3389_fcvm_2018_00047 crossref_primary_10_1002_ame2_12568 crossref_primary_10_1016_j_jdsr_2025_07_001 crossref_primary_10_1016_j_mam_2022_101117 crossref_primary_10_1186_s12967_021_03198_2 crossref_primary_10_1177_00220345211029266 crossref_primary_10_1007_s00784_023_05466_5 crossref_primary_10_1038_s41598_020_61819_0 crossref_primary_10_3390_genes9060271 crossref_primary_10_1177_0265539X251381496 crossref_primary_10_1016_j_jdsr_2023_09_001 crossref_primary_10_1111_jcpe_13268 crossref_primary_10_3389_fgene_2021_644101 crossref_primary_10_1111_jre_13162 crossref_primary_10_1038_s41467_019_10630_1 crossref_primary_10_1111_jcpe_13460 crossref_primary_10_1111_jre_12598 crossref_primary_10_3390_jpm12101743 crossref_primary_10_1002_JLB_4MA0720_698RR crossref_primary_10_3390_ijms242316649 crossref_primary_10_1177_00220345221125402 crossref_primary_10_1093_eurjpc_zwad295 crossref_primary_10_3389_fgene_2021_792396 crossref_primary_10_3390_genes11111385 crossref_primary_10_1038_s41598_021_88803_6 crossref_primary_10_1016_j_semnephrol_2025_151567 crossref_primary_10_1111_odi_13231 crossref_primary_10_1111_jcpe_13758 crossref_primary_10_1186_s12890_024_03025_6 crossref_primary_10_1016_j_identj_2024_07_011 crossref_primary_10_1111_jcpe_13712 crossref_primary_10_1007_s40292_021_00466_6 crossref_primary_10_1111_odi_14009 crossref_primary_10_3390_genes12050787 crossref_primary_10_1016_j_jdsr_2022_06_001 crossref_primary_10_1371_journal_pone_0306983 crossref_primary_10_1186_s12903_021_01964_8 crossref_primary_10_1111_prd_12232 crossref_primary_10_1016_j_jdsr_2020_12_001 crossref_primary_10_1111_prd_12357 crossref_primary_10_1093_jncics_pkab037 crossref_primary_10_3389_fimmu_2018_02885 crossref_primary_10_1177_00220345221123256 crossref_primary_10_1111_omi_12377 crossref_primary_10_1111_ahg_12481 crossref_primary_10_1186_s12903_024_04799_1 |
| ContentType | Journal Article |
| Copyright | The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com. |
| Copyright_xml | – notice: The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com. |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1093/hmg/ddx151 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Medicine Biology |
| EISSN | 1460-2083 |
| ExternalDocumentID | 28449029 |
| Genre | Journal Article |
| GroupedDBID | --- -DZ -E4 .2P .I3 .XZ .ZR 0R~ 18M 1TH 29I 2WC 4.4 482 48X 53G 5GY 5RE 5VS 5WA 5WD 70D AABZA AACZT AAIMJ AAJKP AAJQQ AAMDB AAMVS AAOGV AAPNW AAPQZ AAPXW AARHZ AAUAY AAUQX AAVAP AAVLN ABDFA ABEJV ABEUO ABGNP ABIXL ABJNI ABKDP ABLJU ABMNT ABNHQ ABNKS ABPQP ABPTD ABQLI ABVGC ABWST ABXVV ABXZS ABZBJ ACGFO ACGFS ACPRK ACUFI ACUTJ ACUTO ADBBV ADEYI ADEZT ADFTL ADGKP ADGZP ADHKW ADHZD ADIPN ADNBA ADOCK ADQBN ADRTK ADVEK ADYVW ADZTZ ADZXQ AEGPL AEGXH AEJOX AEKSI AELWJ AEMDU AENEX AENZO AEPUE AETBJ AEWNT AFFZL AFGWE AFIYH AFOFC AFYAG AGINJ AGKEF AGORE AGQXC AGSYK AHMBA AHMMS AHXPO AIAGR AIJHB AJBYB AJEEA AJNCP AKHUL AKWXX ALMA_UNASSIGNED_HOLDINGS ALUQC ALXQX APIBT APWMN ARIXL ATGXG AXUDD AYOIW BAWUL BAYMD BCRHZ BEYMZ BHONS BQDIO BSWAC BTRTY BVRKM C45 CDBKE CGR CS3 CUY CVF CZ4 DAKXR DIK DILTD DU5 D~K EBS ECM EE~ EIF EJD EMOBN F5P F9B FHSFR FLUFQ FOEOM FOTVD FQBLK GAUVT GJXCC GX1 H13 H5~ HAR HW0 HZ~ IH2 IOX J21 JXSIZ KAQDR KBUDW KOP KQ8 KSI KSN L7B M-Z ML0 N9A NGC NLBLG NOMLY NOYVH NPM NU- NVLIB O9- OAWHX OBC OBOKY OBS OCZFY ODMLO OEB OJQWA OJZSN OK1 OPAEJ OVD OWPYF P2P PAFKI PEELM PQQKQ Q1. Q5Y R44 RD5 ROL ROX ROZ RUSNO RW1 RXO SJN TEORI TJX TLC TMA TR2 W8F WOQ X7H XSW YAYTL YKOAZ YXANX ZKX ~91 7X8 |
| ID | FETCH-LOGICAL-c440t-dca67187b040abe04a298f6bcb3532eb7c1e3e6297cc1d9a7ea1f5ec235e21ea2 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 92 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000403460700018&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1460-2083 |
| IngestDate | Thu Oct 02 05:28:27 EDT 2025 Mon Jul 21 06:05:17 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 13 |
| Language | English |
| License | The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c440t-dca67187b040abe04a298f6bcb3532eb7c1e3e6297cc1d9a7ea1f5ec235e21ea2 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://academic.oup.com/hmg/article-pdf/26/13/2577/23593567/ddx151.pdf |
| PMID | 28449029 |
| PQID | 1893552938 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_1893552938 pubmed_primary_28449029 |
| PublicationCentury | 2000 |
| PublicationDate | 2017-07-01 |
| PublicationDateYYYYMMDD | 2017-07-01 |
| PublicationDate_xml | – month: 07 year: 2017 text: 2017-07-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | Human molecular genetics |
| PublicationTitleAlternate | Hum Mol Genet |
| PublicationYear | 2017 |
| SSID | ssj0016437 |
| Score | 2.5252745 |
| Snippet | Periodontitis is one of the most common inflammatory diseases, with a prevalence of 11% worldwide for the severe forms and an estimated heritability of 50%.... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 2577 |
| SubjectTerms | Adult Aggressive Periodontitis - genetics alpha-Defensins - genetics alpha-Defensins - metabolism Antigens, CD - genetics Antigens, CD - metabolism Antigens, Differentiation, Myelomonocytic - genetics Antigens, Differentiation, Myelomonocytic - metabolism Case-Control Studies Chronic Periodontitis - genetics Female Genetic Loci Genetic Predisposition to Disease Genome-Wide Association Study Genotype Humans Lectins - genetics Lectins - metabolism Male Middle Aged Nucleotides Peptides, Cyclic - genetics Peptides, Cyclic - metabolism Phenotype Polymorphism, Single Nucleotide - genetics Risk Factors Turkey |
| Title | A genome-wide association study identifies nucleotide variants at SIGLEC5 and DEFA1A3 as risk loci for periodontitis |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/28449029 https://www.proquest.com/docview/1893552938 |
| Volume | 26 |
| WOSCitedRecordID | wos000403460700018&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3JTsMwELXYxYV9X2QkrlZjO07iE6qgBSSokFjUW-VlAj2QAi3b3zNOUvWEhMQlByuJrPHYb-x5fkPIsdI2EQjdzEkrWBznwKyQmimZ5DxJpeKlAt_DVdrpZN2uvqkP3IY1rXK8JpYLtR-4cEbe4FlQAkdwyk5eXlmoGhWyq3UJjWkyKzGUCZSutDvJIoSkVHW7KEJvyORYnlTLxtPzY8P7L67476FlCTHt5f92boUs1cElbVbesEqmoFgj81W5ye81snBdJ9LXyahJgzrrM7DPvgdqJoNES8FZ2vcVjQiGtAiSx4NReO8Dd9aBOEPNiN5enl-1ThU1hadnrXaTNyX-hwauOkWE7FMMh2nQUcaNbyncOtwg9-3W3ekFqwswMBfH0Yh5ZxLErtTiTDcWotgIneWJdVYqKcCmjoOEROjUOe61ScHwXIETUoHgYMQmmSkGBWwTGuVJju2GS-dj57x1KoRC4DXPEUTTHXI0tmwPHTxkLUwBg_dhb2LbHbJVDU_vpVLi6CG2xjoSevcPX--RRREguaTa7pPZHKc3HJA594EGeDssPQefnZvrHzwCzrA |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+genome-wide+association+study+identifies+nucleotide+variants+at+SIGLEC5+and+DEFA1A3+as+risk+loci+for+periodontitis&rft.jtitle=Human+molecular+genetics&rft.au=Munz%2C+Matthias&rft.au=Willenborg%2C+Christina&rft.au=Richter%2C+Gesa+M&rft.au=Jockel-Schneider%2C+Yvonne&rft.date=2017-07-01&rft.issn=1460-2083&rft.eissn=1460-2083&rft.volume=26&rft.issue=13&rft.spage=2577&rft_id=info:doi/10.1093%2Fhmg%2Fddx151&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1460-2083&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1460-2083&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1460-2083&client=summon |