Biochemical studies on the reverse transcriptase and RNase H activities from human immunodeficiency virus strains resistant to 3'-azido-3'-deoxythymidine

A series of biochemical investigations to compare the DNA polymerase and RNase H functions of the reverse transcriptases (RTs) corresponding to azidothymidine (AZT)-sensitive and -resistant human immunodeficiency virus (HIV) strains are described. Steady-state kinetic studies with purified recombina...

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Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 267; no. 22; p. 15789
Main Authors:	Lacey, S F, Reardon, J E, Furfine, E S, Kunkel, T A, Bebenek, K, Eckert, K A, Kemp, S D, Larder, B A
Format:	Journal Article
Language:	English
Published:	United States 05.08.1992
Subjects:	Antiviral Agents - pharmacology Cell Line Drug Resistance, Microbial - physiology HIV - drug effects HIV - enzymology HIV - genetics Humans Kinetics Polynucleotides Recombinant Proteins - metabolism Reverse Transcriptase Inhibitors Ribonuclease H - metabolism RNA-Directed DNA Polymerase - metabolism Species Specificity Substrate Specificity Zidovudine - pharmacology
ISSN:	0021-9258
Online Access:	Get more information
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