Biochemical studies on the reverse transcriptase and RNase H activities from human immunodeficiency virus strains resistant to 3'-azido-3'-deoxythymidine

A series of biochemical investigations to compare the DNA polymerase and RNase H functions of the reverse transcriptases (RTs) corresponding to azidothymidine (AZT)-sensitive and -resistant human immunodeficiency virus (HIV) strains are described. Steady-state kinetic studies with purified recombina...

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Vydané v:	The Journal of biological chemistry Ročník 267; číslo 22; s. 15789
Hlavní autori:	Lacey, S F, Reardon, J E, Furfine, E S, Kunkel, T A, Bebenek, K, Eckert, K A, Kemp, S D, Larder, B A
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 05.08.1992
Predmet:	Antiviral Agents - pharmacology Cell Line Drug Resistance, Microbial - physiology HIV - drug effects HIV - enzymology HIV - genetics Humans Kinetics Polynucleotides Recombinant Proteins - metabolism Reverse Transcriptase Inhibitors Ribonuclease H - metabolism RNA-Directed DNA Polymerase - metabolism Species Specificity Substrate Specificity Zidovudine - pharmacology
ISSN:	0021-9258
On-line prístup:	Zistit podrobnosti o prístupe
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