Stabilization of Protein–Protein Interactions in chemical biology and drug discovery

More than 300,000 Protein–Protein Interactions (PPIs) can be found in human cells. This number is significantly larger than the number of single proteins, which are the classical targets for pharmacological intervention. Hence, specific and potent modulation of PPIs by small, drug-like molecules wou...

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Bibliographic Details
Published in:	Progress in biophysics and molecular biology Vol. 119; no. 1; pp. 10 - 19
Main Authors:	Bier, David, Thiel, Philipp, Briels, Jeroen, Ottmann, Christian
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.10.2015
Subjects:	Biological Products - pharmacology Drug Discovery - methods Humans Interface stabilization Natural products Protein Interaction Maps - drug effects Protein-ligand interaction Proteins - chemistry Proteins - metabolism Small molecules X-ray crystallography X-ray crystallography Small molecules Natural products Protein-ligand interaction Interface stabilization
ISSN:	0079-6107, 1873-1732, 1873-1732
Online Access:	Get full text
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