Bacillus anthracis, “la maladie du charbon”, Toxins, and Institut Pasteur

Institut Pasteur and Bacillus anthracis have enjoyed a relationship lasting almost 120 years, starting from its foundation and the pioneering work of Louis Pasteur in the nascent fields of microbiology and vaccination, and blooming after 1986 following the molecular biology/genetic revolution. This...

Celý popis

Uložené v:
Podrobná bibliografia
Vydané v:Toxins Ročník 16; číslo 2; s. 66
Hlavný autor: Goossens, Pierre L.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland MDPI AG 26.01.2024
MDPI
Predmet:
19th century
anthracis toxins
Anthrax
Archives & records
Bacillus anthracis
Cell interactions
Cholera
Complex systems
Genetic analysis
Immunization
Institut Pasteur
Laboratories
Microbiology
Molecular biology
Pasteur, Louis (1822-1895)
Pathogenicity
Pathogens
Rabies
regulations
Review
Structural analysis
Toxins
Tropical diseases
Vaccines
Bacillus anthracis
anthracis toxins
vaccines
regulations
Institut Pasteur
societal control
anthrax
ISSN:2072-6651, 2072-6651
On-line prístup:Získať plný text
Tagy: Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
Popis
Shrnutí:Institut Pasteur and Bacillus anthracis have enjoyed a relationship lasting almost 120 years, starting from its foundation and the pioneering work of Louis Pasteur in the nascent fields of microbiology and vaccination, and blooming after 1986 following the molecular biology/genetic revolution. This contribution will give a historical overview of these two research eras, taking advantage of the archives conserved at Institut Pasteur. The first era mainly focused on the production, characterisation, surveillance and improvement of veterinary anthrax vaccines; the concepts and technologies with which to reach a deep understanding of this research field were not yet available. The second period saw a new era of B. anthracis research at Institut Pasteur, with the anthrax laboratory developing a multi-disciplinary approach, ranging from structural analysis, biochemistry, genetic expression, and regulation to bacterial-host cell interactions, in vivo pathogenicity, and therapy development; this led to the comprehensive unravelling of many facets of this toxi-infection. B. anthracis may exemplify some general points on how science is performed in a given society at a given time and how a scientific research domain evolves. A striking illustration can be seen in the additive layers of regulations that were implemented from the beginning of the 21st century and their impact on B. anthracis research. B. anthracis and anthrax are complex systems that raise many valuable questions regarding basic research. One may hope that B. anthracis research will be re-initiated under favourable circumstances later at Institut Pasteur.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ISSN:2072-6651
2072-6651
DOI:10.3390/toxins16020066