The (I/Y)XGG motif of adenovirus DNA polymerase affects template DNA binding and the transition from initiation to elongation

Adenovirus DNA polymerase (Ad pol) is a eukaryotic-type DNA polymerase involved in the catalysis of protein-primed initiation as well as DNA polymerization. The functional significance of the (I/Y)XGG motif, highly conserved among eukaryotic-type DNA polymerases, was analyzed in Ad pol by site-direc...

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Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 276; no. 32; p. 29846
Main Authors:	Brenkman, A B, Heideman, M R, Truniger, V, Salas, M, van der Vliet, P C
Format:	Journal Article
Language:	English
Published:	United States 10.08.2001
Subjects:	Adenoviridae - enzymology Amino Acid Motifs Amino Acid Sequence Amino Acids - chemistry Binding Sites Catalysis DNA - metabolism DNA Mutational Analysis DNA-Binding Proteins - metabolism DNA-Directed DNA Polymerase - chemistry Dose-Response Relationship, Drug Glycerol - pharmacology Kinetics Molecular Sequence Data Mutagenesis, Site-Directed Mutation Protein Binding
ISSN:	0021-9258
Online Access:	Get more information
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