Extracellular superoxide dismutase, a molecular transducer of health benefits of exercise

Extracellular superoxide dismutase (EcSOD) is the only extracellular scavenger of superoxide anion (O2.-) with unique binding capacity to cell surface and extracellular matrix through its heparin-binding domain. Enhanced EcSOD activity prevents oxidative stress and damage, which are fundamental in a...

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Bibliographic Details
Published in:Redox biology Vol. 32; p. 101508
Main Authors: Yan, Zhen, Spaulding, Hannah R.
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01.05.2020
Elsevier
Subjects:
Animals
EcSOD
Endothelial cell activation
Endothelial dysfunction
Exercise
Humans
Oxidative Stress
Review
Superoxide Dismutase - metabolism
Superoxides
Transducers
EcSOD
Endothelial dysfunction
Oxidative stress
Exercise
Endothelial cell activation
ISSN:2213-2317, 2213-2317
Online Access:Get full text
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Summary:Extracellular superoxide dismutase (EcSOD) is the only extracellular scavenger of superoxide anion (O2.-) with unique binding capacity to cell surface and extracellular matrix through its heparin-binding domain. Enhanced EcSOD activity prevents oxidative stress and damage, which are fundamental in a variety of disease pathologies. In this review we will discuss the findings in humans and animal studies supporting the benefits of EcSOD induced by exercise training in reducing oxidative stress in various tissues. In particularly, we will highlight the importance of skeletal muscle EcSOD, which is induced by endurance exercise and redistributed through the circulation to the peripheral tissues, as a molecular transducer of exercise training to confer protection against oxidative stress and damage in various disease conditions.
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ISSN:2213-2317
2213-2317
DOI:10.1016/j.redox.2020.101508